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Gene · 392

ARHGAP1: Rho GTPase activating protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ARHGAP1: Rho GTPase activating protein 1. Genes, record 392. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/392

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Gene

Symbol
ARHGAP1
HGNC
Name
Rho GTPase activating protein 1
HGNC
NCBI Gene ID
392
NCBI Gene
HGNC ID
HGNC:673
HGNC
Ensembl
ENSG00000175220
NCBI Gene
Aliases
CDC42GAP, Cdc42GAP, RHOGAP, RHOGAP1, RhoGAP, p50rhoGAP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q07960Rho GTPase-activating protein 143911Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461667Q07960Espacenet
EP 4650780 A22025-11-194694Q07960Espacenet
JP 2025529142 A2025-09-04439Q07960Espacenet
US 12371689 B22025-07-29439Q07960Espacenet
JP 2025517970 A2025-06-124694Q07960Espacenet
US 11446398 B22022-09-2073190Q07960Espacenet
US 11400116 B22022-08-023014Q07960Espacenet
JP 2022524081 A2022-04-27176161Q07960Espacenet
US 11078247 B22021-08-03710Q07960Espacenet
US 10859577 B22020-12-083Q07960Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,314

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleARHGAP1 papersNewest fiscal year
P30DK045735Yale Diabetes Research Center82025
ZIABC007365Regulation of ADP-ribosylation factor82025
P30CA008748Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant72025
P30DA018343Yale/NIDA Neuroproteomics Center72025
ZIABC008905Tumor gene expression in vitro and in vivo72025
R01AR041398Novel Molecular Biomarkers of Bone Microarchitecture62025
P40OD010440Caenorhabditis Genetics Center52025
R01DK064380Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and Ciliogenesis52025
P30CA016086Cancer Center Support Grant42025

1 to 10 of 1,314Source NIH's project files

See all 1,314 nih grants

Papers1,758

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
How Functional Variants Reconfigure the Rac2 Conformational Landscape.J Phys Chem B202642593131PubTator, text miningPubMed
A Rho GTPase-activating protein plays a positive role in tobacco resistance against chili veinal mottle virus.Plant Physiol202642478924PubTator, text miningPubMed
Transcriptomic Profiling and WGCNA Identify ALOX5 as a Key Regulator of Iron Metabolism and Immune Crosstalk in Venous Thromboembolism.Curr Issues Mol Biol202642353611PubTator, text miningPubMed
Extracellular vesicle cargo dynamics in the bone marrow microenvironment: from hematopoietic homeostasis to malignant transformation.Extracell Vesicle202642344609PubTator, text miningPubMed
Glutamine Tautomerization Drives RhoGAP-Aided GTP Hydrolysis in Small Rho GTPases.J Am Chem Soc202642297792PubTator, text miningPubMed
The multifaceted role of FAM13A in pulmonary diseases.Front Genet202642266412PubTator, text miningPubMed
How Functional Variants Reconfigure the Rac2 Conformational Landscape.bioRxiv202642039397PubTator, text miningPubMed
DEPDC7 as a potential tumor suppressor in hepatocellular carcinoma: preliminary evidence for targeting the JAK1/STAT3 axis.Front Oncol202641930189PubTator, text miningPubMed
Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission.Commun Biol202641862576PubTator, text miningPubMed
Duplication of the prothrombin gene is associated with a significant increase in thrombin generation.Res Pract Thromb Haemost202641769318PubTator, text miningPubMed

1 to 10 of 1,758

See all 1,758 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/392

GET https://conductscience.org/api/genes/v1/392/patents?page=2