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LCAT: lecithin-cholesterol acyltransferase

1 protein, 61 patents, 0 drugs, 0 trials, 2,048 NIH grants and 5,398 papers.

Gene 6

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLCATHGNC
Namelecithin-cholesterol acyltransferaseHGNC
NCBI Gene ID3931NCBI Gene
HGNC IDHGNC:6522HGNC
EnsemblENSG00000213398NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04180Phosphatidylcholine-sterol acyltransferase4407Ensembl, GeneID, HGNCUniProt

Patents 61

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21416P04180Espacenet
EP 4650780 A22025-11-192284P04180Espacenet
JP 2025169942 A2025-11-141123P04180Espacenet
JP 2025147176 A2025-10-067730P04180Espacenet
JP 2025529142 A2025-09-046865P04180Espacenet
US 12371689 B22025-07-296865P04180Espacenet
JP 2025517970 A2025-06-122284P04180Espacenet
JP 2025032204 A2025-03-1130722P04180Espacenet
JP 2025028160 A2025-02-287730P04180Espacenet
KR 1020250010750 A2025-01-217730P04180Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2048

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK017047Diabetes Research Center302,025NIH's project files
P01HL128203Multi-disciplinary Approaches to HDL Structure, Assembly, and Functional Heterogeneity132,025NIH's project files
P01HL116263HDL Function in Human Disease112,025NIH's project files
P30CA012197Cancer Center Support Grant112,025NIH's project files
P30DK035816Nutrition Obesity Research Center112,025NIH's project files
P30CA068485Cancer Center Support Grant72,025NIH's project files
R01GM147545Development of a Novel Technology for Preparative Fractionation and Characterization of Lipoprotein Particles72,025NIH's project files
P01HL151328Triglycerides, Diabetes and Cardiovascular Disease62,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases62,025NIH's project files
P30DK020593Vanderbilt Diabetes Research Center52,025NIH's project files

Papers 5398

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42794497PubTator, text miningPubMed
42729454PubTator, text miningPubMed
42639673PubTator, text miningPubMed
42617593PubTator, text miningPubMed
42592650PubTator, text miningPubMed
42556584PubTator, text miningPubMed
42520984PubTator, text miningPubMed
42476420PubTator, text miningPubMed
42459753PubTator, text miningPubMed
42436206PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license