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LCK: LCK proto-oncogene, Src family tyrosine kinase

1 protein, 80 patents, 8 drugs, 436 trials, 5,719 NIH grants and 9,309 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLCKHGNC
NameLCK proto-oncogene, Src family tyrosine kinaseHGNC
NCBI Gene ID3932NCBI Gene
HGNC IDHGNC:6524HGNC
EnsemblENSG00000182866NCBI Gene
AliasesIMD22, LSK, YT16, p56lck, pp58lckNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P06239Tyrosine-protein kinase Lck50957Ensembl, GeneID, HGNCUniProt

Patents 80

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026514993 A2026-05-13103P06239Espacenet
JP 2025541700 A2025-12-23155P06239Espacenet
EP 4661970 A12025-12-1762158P06239Espacenet
WO 2025252547 A12025-12-1162P06239Espacenet
EP 4660322 A12025-12-1062P06239Espacenet
US 12478626 B22025-11-252P06239Espacenet
US 12215347 B22025-02-042P06239Espacenet
WO 2025016918 A12025-01-2362P06239Espacenet
EP 4495265 A12025-01-2262P06239Espacenet
EP 4458847 A22024-11-0639P06239Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DASATINIB ANHYDROUSCHEMBL1421SRC inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885SRC inhibitorINHIBITORChEMBL
ILORASERTIBCHEMBL1980297SRC inhibitorINHIBITORChEMBL
JNJ-26483327CHEMBL3109738Tyrosine-protein kinase LCK inhibitorINHIBITORChEMBL
PAZOPANIBCHEMBL477772Tyrosine-protein kinase LCK inhibitorINHIBITORChEMBL
PAZOPANIB HYDROCHLORIDECHEMBL1201733Tyrosine-protein kinase LCK inhibitorINHIBITORChEMBL
TG100-801CHEMBL403989SRC inhibitorINHIBITORChEMBL
XL-228CHEMBL3545085SRC inhibitorINHIBITORChEMBL

Trials 436

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07444619PAZOPANIBPHASE1ClinicalTrials.gov
NCT07087158PAZOPANIBPHASE2ClinicalTrials.gov
NCT06816771PAZOPANIBPHASE2ClinicalTrials.gov
NCT06726421PAZOPANIBPHASE3ClinicalTrials.gov
NCT06390319DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06355037DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06336395DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06263231PAZOPANIBPHASE3ClinicalTrials.gov
NCT06124157DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06055621DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov

NIH grants 5719

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant702,025NIH's project files
P30CA008748Cancer Center Support Grant532,025NIH's project files
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR432,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)212,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)212,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase202,025NIH's project files
P30CA086862Cancer Center Support Grant192,025NIH's project files
P30CA047904Cancer Center Support Grant142,025NIH's project files
R01GM086858New Molecular Probes For Protein Kinases122,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant112,025NIH's project files

Papers 9309

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42724716PubTator, text miningPubMed
42701720PubTator, text miningPubMed
42693249PubTator, text miningPubMed
42685040PubTator, text miningPubMed
42685004PubTator, text miningPubMed
42638732PubTator, text miningPubMed
42633313PubTator, text miningPubMed
42621184PubTator, text miningPubMed
42607060PubTator, text miningPubMed
42519578PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license