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Gene · 3937

LCP2: lymphocyte cytosolic protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LCP2: lymphocyte cytosolic protein 2. Genes, record 3937. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3937

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Gene

Symbol
LCP2
HGNC
Name
lymphocyte cytosolic protein 2
HGNC
NCBI Gene ID
3937
NCBI Gene
HGNC ID
HGNC:6529
HGNC
Ensembl
ENSG00000043462
NCBI Gene
Aliases
IMD81, SLP-76, SLP76
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13094Lymphocyte cytosolic protein 25335Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452023Q13094Espacenet
EP 4661970 A12025-12-1762159Q13094Espacenet
EP 4661970 A12025-12-1762177Q13094Espacenet
EP 4641201 A22025-10-2961Q13094Espacenet
JP 2025517969 A2025-06-1261Q13094Espacenet
JP 2024508707 A2024-02-28226Q13094Espacenet
US 11884978 B22024-01-30571Q13094Espacenet
JP 2023540750 A2023-09-263Q13094Espacenet
KR 1020230061507 A2023-05-082Q13094Espacenet
US 11446398 B22022-09-2047570Q13094Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,343

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLCP2 papersNewest fiscal year
ZIABC010304Biochemical Basis of T Cell Activation242025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR222025
ZICBC010978Confocal Core for the Laboratory of Cellular and Molecular Biology122025
P30CA008748Cancer Center Support Grant112025
P30CA086862Cancer Center Support Grant102025
R01AI043957Structural Studies of a T cell Specific Tyrosine Kinase102025
T32AI007485Predoctoral Training Program in Immunology92025
P30CA016672Cancer Center Support Grant62025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged62025
P20GM121293Center for Translational Pediatric Research42025

1 to 10 of 1,343Source NIH's project files

See all 1,343 nih grants

Papers1,973

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Immunosuppressive effects of voclosporin in inflammatory bowel disease through targeted inhibition of SLP-76 and metabolic reprogramming.J Immunol202642501366PubTator, text miningPubMed
Systematic Identification of Immune Regulatory Gene Networks in Leukemia Using Integrated Transcriptomic and Functional Analyses.Curr Pharm Biotechnol202642227409PubTator, text miningPubMed
Differential Expression Analysis of Key Inflammatory Mediators in Irreversible Pulpitis for Diagnostic Biomarkers.Int Dent J202642217380PubTator, text miningPubMed
LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma.Cell Death Dis202642209466PubTator, text miningPubMed
Targeting the STAT5A-LCP2-NF-κB Pathway to Overcome PD-1 Resistance in Esophageal Cancer.Antioxid Redox Signal202642203639PubTator, text miningPubMed
Integrative single-cell transcriptomics and co-expression network analysis identify SIMALR as a prognostic immune-related lncRNA in breast cancer: in silico analysis and validation.Naunyn Schmiedebergs Arch Pharmacol202642103982PubTator, text miningPubMed
HPK1 inhibitor NDI-101150 as monotherapy and in combination with pembrolizumab in patients with advanced solid tumors: Phase 1/2 trial results.Cell Rep Med202642097144PubTator, text miningPubMed
Construction and experimental verification of a prognostic model based on tumor-infiltrating lymphocytes related genes (TILRGs) in diffuse large B-cell lymphoma.SLAS Technol202642070751PubTator, text miningPubMed
KR-62980, a novel PPARγ agonist, inhibits collagen-induced platelet activation and thrombus formation by regulating the GPVI signaling pathway.Biochem Pharmacol202641871717PubTator, text miningPubMed
Non-invasive host transcriptome and HPV oncogene expression map the molecular landscape of HPV-driven cervical lesions.PLoS One202641855211PubTator, text miningPubMed

1 to 10 of 1,973

See all 1,973 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3937

GET https://conductscience.org/api/genes/v1/3937/patents?page=2