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Gene · 3945

LDHB: lactate dehydrogenase B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LDHB: lactate dehydrogenase B. Genes, record 3945. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3945

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Gene

Symbol
LDHB
HGNC
Name
lactate dehydrogenase B
HGNC
NCBI Gene ID
3945
NCBI Gene
HGNC ID
HGNC:6541
HGNC
Ensembl
ENSG00000111716
NCBI Gene
Aliases
HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07195L-lactate dehydrogenase B chain3347Ensembl, GeneID, HGNC

Source UniProt

Patents89

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451042P07195Espacenet
JP 2026004568 A2026-01-1451044P07195Espacenet
EP 4650780 A22025-11-19735P07195Espacenet
EP 4641201 A22025-10-2939029P07195Espacenet
US 12433933 B22025-10-0754P07195Espacenet
US 12433933 B22025-10-076P07195Espacenet
JP 2025517969 A2025-06-1239029P07195Espacenet
JP 2025517970 A2025-06-12735P07195Espacenet
JP 2024504467 A2024-01-312P07195Espacenet
JP 2024009871 A2024-01-23103P07195Espacenet

1 to 10 of 89

See all 89 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,624

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLDHB papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
P30CA008748Cancer Center Support Grant122025
P41EB013598Hyperpolarized MRI Technology Resource Center62025
P30CA010815Consolidated Basic Cancer Research Program52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P50HD103526MIND Institute Intellectual and Developmental Disabilities Research Center52025
R01CA051497Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis52025
R35CA220449Human metabolic variation as a window into cancer initiation and progression52025
P30CA016042Cancer Center Support Grant42025
P30CA056036Translational Research in Cancer42025

1 to 10 of 1,624Source NIH's project files

See all 1,624 nih grants

Papers2,881

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TLR7/9 and type I interferon signaling reprogram neutrophil NET responses and impair antibacterial defense in systemic lupus erythematosus.Cell Press Blue202642746563PubTator, text miningPubMed
Malic enzyme 1 senses L-lactate to determine tumor heterogeneity.Signal Transduct Target Ther202642728262PubTator, text miningPubMed
Disulfidptosis as an immunometabolic rheostat in gastrointestinal cancers: tuning the balance between T Cell exhaustion and immunogenic cell death.Front Cell Dev Biol202642724329PubTator, text miningPubMed
PHB2 Promotes Glycolytic Reprogramming in Triple-Negative Breast Cancer Through FOXM1-Dependent Activation of LDHB.Carcinogenesis202642710061PubTator, text miningPubMed
Lactylation in sepsis-associated acute kidney injury: regulatory mechanisms and therapeutic prospects.Front Mol Biosci202642688716PubTator, text miningPubMed
The dual role of the cGAS-STING signaling pathway in kidney diseases: from acute injury to chronic fibrosis - molecular mechanisms and precision therapeutic strategies.Front Pharmacol202642621049PubTator, text miningPubMed
Multi-omics-guided identification of blood-entering bioactive components and candidate responsive targets of Shugan Jianpi Tiaochang Pill against colorectal adenoma.Phytomedicine202642607381PubTator, text miningPubMed
Metabolic reprogramming via LDHB confers resistance to lactate-induced dysfunction and enhanced antitumor activity in hiPSC-Derived NK cells.Stem Cell Reports202642594863PubTator, text miningPubMed
Ozone Hydrotherapy Improves Seborrheic Dermatitis by Regulating Scalp Microbiome and Mitochondrial Lactate Shuttle in Keratinocytes.J Infect Dis202642586552PubTator, text miningPubMed
Metabolic reprogramming is associated with symptomatic COVID-19: a serum proteomics and causal inference study identifying ALDOB and glycerol as candidate metabolic correlates.Front Microbiol202642568671PubTator, text miningPubMed

1 to 10 of 2,881

See all 2,881 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3945

GET https://conductscience.org/api/genes/v1/3945/patents?page=2