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LEP: leptin

1 protein, 280 patents, 0 drugs, 0 trials, 17,551 NIH grants and 64,915 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLEPHGNC
NameleptinHGNC
NCBI Gene ID3952NCBI Gene
HGNC IDHGNC:6553HGNC
EnsemblENSG00000174697NCBI Gene
AliasesLEPD, OB, OBSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P41159Leptin16710Ensembl, GeneID, HGNCUniProt

Patents 280

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4727963 A22026-04-2248P41159Espacenet
EP 4650780 A22025-11-194853P41159Espacenet
WO 2025227129 A22025-10-303P41159Espacenet
JP 2025147176 A2025-10-067782P41159Espacenet
JP 2025529142 A2025-09-046881P41159Espacenet
US 12371689 B22025-07-296881P41159Espacenet
JP 2025517970 A2025-06-124853P41159Espacenet
JP 2025028160 A2025-02-287782P41159Espacenet
JP 2025013479 A2025-01-245P41159Espacenet
KR 1020250010750 A2025-01-217782P41159Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 17551

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK020572Michigan Diabetes Research Center (MDRC)1732,025NIH's project files
P30DK026687New York Obesity Research Center1502,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)1272,025NIH's project files
P30DK048520Colorado Nutrition Obesity Research Center1182,025NIH's project files
P30DK072476Pennington/Louisiana NORC1052,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center842,025NIH's project files
P30DK017047Diabetes Research Center802,025NIH's project files
P30DK056336UAB Nutrition Obesity Research Center (NORC)792,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award742,025NIH's project files
P30CA016672Cancer Center Support Grant732,025NIH's project files

Papers 64915

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826315PubTator, text miningPubMed
42823632PubTator, text miningPubMed
42822680PubTator, text miningPubMed
42822528PubTator, text miningPubMed
42819525PubTator, text miningPubMed
42811821PubTator, text miningPubMed
42810262PubTator, text miningPubMed
42809338PubTator, text miningPubMed
42808265PubTator, text miningPubMed
42806711PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license