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LEPR: leptin receptor

1 protein, 89 patents, 2 drugs, 40 trials, 4,864 NIH grants and 8,989 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLEPRHGNC
Nameleptin receptorHGNC
NCBI Gene ID3953NCBI Gene
HGNC IDHGNC:6554HGNC
EnsemblENSG00000116678NCBI Gene
AliasesCD295, LEP-R, LEPRD, OB-R, OBR, huB219NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P48357Leptin receptor1,1659Ensembl, GeneID, HGNCUniProt

Patents 89

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026103182 A2026-06-2412P48357Espacenet
JP 2026004568 A2026-01-1451251P48357Espacenet
WO 2025259600 A22025-12-181P48357Espacenet
JP 2025172069 A2025-11-20239P48357Espacenet
JP 2025166129 A2025-11-05113P48357Espacenet
EP 4641201 A22025-10-295577P48357Espacenet
JP 2025148269 A2025-10-0728P48357Espacenet
WO 2025193896 A22025-09-1828P48357Espacenet
EP 4613772 A22025-09-1089P48357Espacenet
JP 2025529142 A2025-09-042357P48357Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
METRELEPTINCHEMBL2107857Leptin receptor agonistAGONISTChEMBL
MIBAVADEMABCHEMBL4650509Leptin receptor agonistAGONISTChEMBL

Trials 40

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07220785MIBAVADEMABPHASE3ClinicalTrials.gov
NCT07220772MIBAVADEMABPHASE3ClinicalTrials.gov
NCT06679270METRELEPTINPHASE3ClinicalTrials.gov
NCT06548100MIBAVADEMABPHASE3ClinicalTrials.gov
NCT06502990METRELEPTINPHASE3ClinicalTrials.gov
NCT06484868METRELEPTINPHASE4ClinicalTrials.gov
NCT06373146MIBAVADEMABPHASE2ClinicalTrials.gov
NCT06305182METRELEPTINPHASE2ClinicalTrials.gov
NCT05351164METRELEPTINPHASE22025-06-12ClinicalTrials.gov
NCT05164341METRELEPTINPHASE3ClinicalTrials.gov

NIH grants 4864

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK020572Michigan Diabetes Research Center (MDRC)602,025NIH's project files
P30DK026687New York Obesity Research Center402,025NIH's project files
R01DK056731Molecular and Neural Mechanisms of Leptin Action262,025NIH's project files
P30CA016672Cancer Center Support Grant152,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)142,025NIH's project files
P30DK072476Pennington/Louisiana NORC142,025NIH's project files
P30DK017047Diabetes Research Center132,025NIH's project files
P30DK056350Nutrition Obesity Research Center (NORC)132,025NIH's project files
ZIAHD000641Physiology, Psychology, and Genetics of Obesity122,025NIH's project files
P30DK036836Diabetes Research Center112,025NIH's project files

Papers 8989

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821228PubTator, text miningPubMed
42791368PubTator, text miningPubMed
42786937PubTator, text miningPubMed
42786432PubTator, text miningPubMed
42768086PubTator, text miningPubMed
42722967PubTator, text miningPubMed
42689008PubTator, text miningPubMed
42666243PubTator, text miningPubMed
42662722PubTator, text miningPubMed
42649173PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license