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Gene · 396

ARHGDIA: Rho GDP dissociation inhibitor alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ARHGDIA: Rho GDP dissociation inhibitor alpha. Genes, record 396. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/396

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Gene

Symbol
ARHGDIA
HGNC
Name
Rho GDP dissociation inhibitor alpha
HGNC
NCBI Gene ID
396
NCBI Gene
HGNC ID
HGNC:678
HGNC
Ensembl
ENSG00000141522
NCBI Gene
Aliases
GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P52565Rho GDP-dissociation inhibitor 120421Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192703P52565Espacenet
JP 2025517970 A2025-06-122703P52565Espacenet
JP 2024123008 A2024-09-108199P52565Espacenet
JP 2024123008 A2024-09-108201P52565Espacenet
EP 4384828 A12024-06-1931P52565Espacenet
JP 2023064789 A2023-05-1282P52565Espacenet
WO 2023074712 A2023-05-0428P52565Espacenet
US 11446398 B22022-09-2073168P52565Espacenet
US 11446398 B22022-09-2073170P52565Espacenet
US 11446398 B22022-09-2073177P52565Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,554

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleARHGDIA papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant82025
P30CA016087Cancer Center Support Grant52025
P30CA046934University of Colorado Cancer Center Support Grant42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA068485Cancer Center Support Grant32025
P30EY014800University of Utah Core Vision Research Grant32025
P50CA127001SPORE in Brain Cancer32025

1 to 10 of 1,554Source NIH's project files

See all 1,554 nih grants

Papers1,898

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Twist1 Promotes Endothelial Phenotypic Transition and Unstable Plaque Phenotype During Atherosclerosis.Arterioscler Thromb Vasc Biol202642689320PubTator, text miningPubMed
A novel circSLIT2-encoded SLIT2 isoform suppresses neural invasion in gastric cancer.Oncogene202642362756PubTator, text miningPubMed
Acute capillary blood DNA methylation responses to swimming exercise in high-performance male and female swimmers.Exp Physiol202642285772PubTator, text miningPubMed
Inhibiting RhoA Activation Via GDP-State Stabilization to Relieve Heart Failure.Circ Res202641859798PubTator, text miningPubMed
A New Single-Chain, Genetically Encoded Biosensor for RhoB GTPase Based on FRET, Useful for Live-Cell Imaging.Cells202641744790PubTator, text miningPubMed
Impact of mare milk-derived small extracellular vesicles on proliferation, phagocytosis, and migration in RAW264.7 macrophage.Sci Rep202641629461PubTator, text miningPubMed
Synthetic essentiality of isoprenylcysteine carboxylmethyltransferase in PTEN deficient triple negative breast cancer.Exp Hematol Oncol202641507994PubTator, text miningPubMed
DAT-delivered astaxanthin reprograms adipogenesis through RhoGDI1 dephosphorylation at Ser174 and RhoA/FAK/ERK1/2 cascade suppression.Biomaterials202641506140PubTator, text miningPubMed
Dysregulation of ERAD and Stress Response Proteins by V493F FTO Over-expression: A Proteomic Perspective.In Vivo202641482413PubTator, text miningPubMed
PknG Protein of Mycobacterium tuberculosis Targets RGDI-1 to Regulate Rab7l1 GTPase Activity.ACS Infect Dis202641439637PubTator, text miningPubMed

1 to 10 of 1,898

See all 1,898 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/396

GET https://conductscience.org/api/genes/v1/396/patents?page=2