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Gene · 3973

LHCGR: luteinizing hormone/choriogonadotropin receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LHCGR: luteinizing hormone/choriogonadotropin receptor. Genes, record 3973. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3973

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Gene

Symbol
LHCGR
HGNC
Name
luteinizing hormone/choriogonadotropin receptor
HGNC
NCBI Gene ID
3973
NCBI Gene
HGNC ID
HGNC:6585
HGNC
Ensembl
ENSG00000138039
NCBI Gene
Aliases
HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22888Lutropin-choriogonadotropic hormone receptor6994Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451969P22888Espacenet
EP 4650780 A22025-11-193583P22888Espacenet
EP 4641201 A22025-10-293176P22888Espacenet
JP 2025147176 A2025-10-067851P22888Espacenet
JP 2025529142 A2025-09-042366P22888Espacenet
JP 2025529142 A2025-09-046891P22888Espacenet
JP 2025524365 A2025-07-301P22888Espacenet
US 12371689 B22025-07-292366P22888Espacenet
US 12371689 B22025-07-296891P22888Espacenet
JP 2025517969 A2025-06-123176P22888Espacenet

1 to 10 of 37

See all 37 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CHORIOGONADOTROPIN ALFACHEMBL1201464Luteinizing hormone/Choriogonadotropin receptor agonistAGONISTChEMBL
GONADOTROPIN, CHORIONICCHEMBL1201509Luteinizing hormone/Choriogonadotropin receptor agonistAGONISTChEMBL
LH (MENOTROPINS)CHEMBL1201697Luteinizing hormone/Choriogonadotropin receptor agonistAGONISTChEMBL
LUTROPIN ALFACHEMBL1201419Luteinizing hormone/Choriogonadotropin receptor agonistAGONISTChEMBL
MENOTROPINSCHEMBL2108427Luteinizing hormone/Choriogonadotropin receptor agonistAGONISTChEMBL

Trials221

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07481370CHORIOGONADOTROPIN ALFAPHASE2ClinicalTrials.gov
NCT07481370GONADOTROPIN, CHORIONICPHASE2ClinicalTrials.gov
NCT07216742MENOTROPINSPHASE3ClinicalTrials.gov
NCT07148999MENOTROPINSPHASE1/PHASE2ClinicalTrials.gov
NCT07128394LUTROPIN ALFAClinicalTrials.gov
NCT06997900MENOTROPINSPHASE2ClinicalTrials.gov
NCT06904599CHORIOGONADOTROPIN ALFAPHASE2ClinicalTrials.gov
NCT06904599GONADOTROPIN, CHORIONICPHASE2ClinicalTrials.gov
NCT06883890LUTROPIN ALFAPHASE2ClinicalTrials.gov
NCT06803199LUTROPIN ALFAClinicalTrials.gov

1 to 10 of 221

See all 221 trials

NIH grants1,344

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLHCGR papersNewest fiscal year
P01AG029531The Aging Pituitary/Gonadal Axis112025
P51OD011092Support for National Primate Research Center92025
P30CA008748Cancer Center Support Grant72025
R01EY011500Structure-function studies of visual arrestin62025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease52025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
R01DK043140Mechanisms Leading to Adrenal Zonation42025
T32DK007169NW University Program in Endo Diabetes and Hormone Action42025
T32HD007203Training in Reproductive Sciences42025
ZIEHD008737Reproductive Endocrinology and Infertility Clinical Training Program42025

1 to 10 of 1,344Source NIH's project files

See all 1,344 nih grants

Papers3,823

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Phenotype-Specific Association of LHCGR rs13405728 Polymorphism with Anovulatory Infertility in Malay Women with Polycystic Ovary Syndrome: A Case-Control Study.Int J Fertil Steril202642703834PubTator, text miningPubMed
LHCGR phamacodynamic effects during follicular maturation.Front Endocrinol (Lausanne)202642657199PubTator, text miningPubMed
Pregnancy-induced Cushing syndrome mediated by overexpressing LHCGR with bilateral micronodular adrenocortical disease.JCEM Case Rep202642656546PubTator, text miningPubMed
Optimisation of Dietary Lipid in Genetically Selected Clarias magur in Term of Gonadal Growth, Reproductive Performance, and Expression of Reproduction-Related Genes.J Anim Physiol Anim Nutr (Berl)202642641055PubTator, text miningPubMed
The significance of blood indicators in distinguishing bipolar disorder depressive episodes from major depression in teenagers.Front Psychiatry202642626262PubTator, text miningPubMed
Ovarian Function, Hormonal, Metabolic, Oxidative Stress, and Gene Expression Biomarker Responses of Holstein Heifers Under Heat Stress Conditions to a Reduced Dose of Nanofabricated GnRH Analog Within the Ovsynch Protocol.
Animals (Basel)202642511042PubTator, text miningPubMed
Empty Follicle Syndrome: Current Therapeutic Approaches and the Role of Triggering Agents in Assisted Reproductive Technology.Med Sci (Basel)202642506338PubTator, text miningPubMed
Isolation of theca cells from human antral follicle membranes using ANPEP-based magnetic cell sorting.J Assist Reprod Genet202642489828PubTator, text miningPubMed
A Miswired Ovarian Ecosystem: LIF/JAK/STAT3 Distortion in PCOS.Reprod Sci202642486999PubTator, text miningPubMed
Integrated Genomic, Transcriptomic, and Circulating Biomarkers Predict Benefit to Immune Checkpoint Inhibitor Plus Chemotherapy in Advanced Non-Small Cell Lung Cancer.MedComm (2020)202642415854PubTator, text miningPubMed

1 to 10 of 3,823

See all 3,823 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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