Gene · 3977
LIFR: LIF receptor subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LIFR: LIF receptor subunit alpha. Genes, record 3977. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3977
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P42702 | Leukemia inhibitory factor receptor | 1,097 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents80
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 51424 | P42702 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 51425 | P42702 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1777 | P42702 | Espacenet |
| EP 4633648 A1 | 2025-10-22 | 41 | P42702 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 7860 | P42702 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 7861 | P42702 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16660 | P42702 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16765 | P42702 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2373 | P42702 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6893 | P42702 | Espacenet |
1 to 10 of 80
See all 80 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,398
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LIFR papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| P20GM103408 | Idaho INBRE Program | 7 | 2025 |
| R01AI051321 | Structure-based engineering of immune cytokine signaling | 7 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 6 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| R01AI127564 | Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis | 5 | 2025 |
| R01CA267893 | Development of new therapeutic approaches for endometrial cancer | 5 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30EY021725 | P30 Center Core Grant for Vision Research | 4 | 2025 |
1 to 10 of 1,398Source NIH's project files
See all 1,398 nih grantsPapers2,592
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Exercise-mediated muscle-bone crosstalk in osteosarcopenia: potential integration through the LIF/LIFR/STAT3 signaling axis. | Prog Biophys Mol Biol | 2026 | 42800618 | PubTator, text mining | PubMed |
| Genetically Predicted Gut Microbial Taxa and Inflammatory Proteins Associated With Atrial Fibrillation: A Bidirectional Mendelian Randomization and Colocalization Study. | J Arrhythm | 2026 | 42798960 | PubTator, text mining | PubMed |
| Recognizing Stuve-Wiedemann syndrome in childhood: clinical insights from 11 patients with founder and novel LIFR variants. | Turk J Pediatr | 2026 | 42777197 | PubTator, text mining | PubMed |
| Severe Suprasystemic Refractory Pulmonary Hypertension in a Neonate with Stüve-Wiedemann Syndrome Associated with Biallelic LIFR Variants: Molecular Insights and a Neonatal Case Report. | Int J Mol Sci | 2026 | 42737721 | PubTator, text mining | PubMed |
| The role of ferroptosis in juvenile idiopathic arthritis: Causal inference and mediation by immune phenotypes. | Medicine (Baltimore) | 2026 | 42700015 | PubTator, text mining | PubMed |
| Optic nerve regeneration requires the intracellular domain of LIFRα/CD118. | JCI Insight | 2026 | 42678930 | PubTator, text mining | PubMed |
| A Stimulus-Resolved Framework for Investigating Putative Neurotrophic Secretome-Metabolome Coupling in Aging Skeletal Muscle: CNTF and CLCF1 as Non-Equivalent Nodes. | Metabolites | 2026 | 42646298 | PubTator, text mining | PubMed |
| Single-cell analysis identifies a VIM+ glioma stem-like vascular-immune state linked to myeloid OSM signaling and CEBPD activity. | Front Immunol | 2026 | 42643588 | PubTator, text mining | PubMed |
| Autosomal recessive OSMRβ deficiency: Connecting OSM and/or IL-31 with atopy. | J Hum Immun | 2026 | 42639505 | PubTator, text mining | PubMed |
| Joined Signatures of Erythropoietin and Interleukin-6 Signaling by Synthetic Heterodimeric gp130:Epo Receptor Complexes. | ACS Synth Biol | 2026 | 42632025 | PubTator, text mining | PubMed |
1 to 10 of 2,592
See all 2,592 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3977
GET https://conductscience.org/api/genes/v1/3977/patents?page=2