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Gene · 3977

LIFR: LIF receptor subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LIFR: LIF receptor subunit alpha. Genes, record 3977. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3977

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Gene

Symbol
LIFR
HGNC
Name
LIF receptor subunit alpha
HGNC
NCBI Gene ID
3977
NCBI Gene
HGNC ID
HGNC:6597
HGNC
Ensembl
ENSG00000113594
NCBI Gene
Aliases
CD118, LIF-R, SJS2, STWS, SWS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P42702Leukemia inhibitory factor receptor1,0976Ensembl, GeneID, HGNC

Source UniProt

Patents80

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451424P42702Espacenet
JP 2026004568 A2026-01-1451425P42702Espacenet
EP 4641201 A22025-10-291777P42702Espacenet
EP 4633648 A12025-10-2241P42702Espacenet
JP 2025147176 A2025-10-067860P42702Espacenet
JP 2025147176 A2025-10-067861P42702Espacenet
JP 2025147176 A2025-10-0616660P42702Espacenet
JP 2025147176 A2025-10-0616765P42702Espacenet
JP 2025529142 A2025-09-042373P42702Espacenet
JP 2025529142 A2025-09-046893P42702Espacenet

1 to 10 of 80

See all 80 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,398

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLIFR papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P20GM103408Idaho INBRE Program72025
R01AI051321Structure-based engineering of immune cytokine signaling72025
P30CA016056Roswell Park Cancer Center Support Grant62025
P30CA068485Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant52025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis52025
R01CA267893Development of new therapeutic approaches for endometrial cancer52025
P30CA014195Cancer Center Support Grant (CCSG)42025
P30EY021725P30 Center Core Grant for Vision Research42025

1 to 10 of 1,398Source NIH's project files

See all 1,398 nih grants

Papers2,592

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exercise-mediated muscle-bone crosstalk in osteosarcopenia: potential integration through the LIF/LIFR/STAT3 signaling axis.Prog Biophys Mol Biol202642800618PubTator, text miningPubMed
Genetically Predicted Gut Microbial Taxa and Inflammatory Proteins Associated With Atrial Fibrillation: A Bidirectional Mendelian Randomization and Colocalization Study.J Arrhythm202642798960PubTator, text miningPubMed
Recognizing Stuve-Wiedemann syndrome in childhood: clinical insights from 11 patients with founder and novel LIFR variants.Turk J Pediatr202642777197PubTator, text miningPubMed
Severe Suprasystemic Refractory Pulmonary Hypertension in a Neonate with Stüve-Wiedemann Syndrome Associated with Biallelic LIFR Variants: Molecular Insights and a Neonatal Case Report.Int J Mol Sci202642737721PubTator, text miningPubMed
The role of ferroptosis in juvenile idiopathic arthritis: Causal inference and mediation by immune phenotypes.Medicine (Baltimore)202642700015PubTator, text miningPubMed
Optic nerve regeneration requires the intracellular domain of LIFRα/CD118.JCI Insight202642678930PubTator, text miningPubMed
A Stimulus-Resolved Framework for Investigating Putative Neurotrophic Secretome-Metabolome Coupling in Aging Skeletal Muscle: CNTF and CLCF1 as Non-Equivalent Nodes.Metabolites202642646298PubTator, text miningPubMed
Single-cell analysis identifies a VIM+ glioma stem-like vascular-immune state linked to myeloid OSM signaling and CEBPD activity.Front Immunol202642643588PubTator, text miningPubMed
Autosomal recessive OSMRβ deficiency: Connecting OSM and/or IL-31 with atopy.J Hum Immun202642639505PubTator, text miningPubMed
Joined Signatures of Erythropoietin and Interleukin-6 Signaling by Synthetic Heterodimeric gp130:Epo Receptor Complexes.ACS Synth Biol202642632025PubTator, text miningPubMed

1 to 10 of 2,592

See all 2,592 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3977

GET https://conductscience.org/api/genes/v1/3977/patents?page=2