Gene · 3978
LIG1: DNA ligase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LIG1: DNA ligase 1. Genes, record 3978. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3978
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P18858 | DNA ligase 1 | 919 | 35 | Ensembl, GeneID, HGNC |
Source UniProt
Patents44
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4780957 A1 | 2026-07-29 | 66 | P18858 | Espacenet |
| EP 4709870 A1 | 2026-03-18 | 56 | P18858 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2189 | P18858 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1755 | P18858 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4560 | P18858 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1755 | P18858 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2189 | P18858 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4560 | P18858 | Espacenet |
| JP 2024543481 A | 2024-11-21 | 56 | P18858 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 312 | P18858 | Espacenet |
1 to 10 of 44
See all 44 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,113
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LIG1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 34 | 2025 |
| R01ES012512 | Roles of Lig3 and XRCC1 Genes in Genome Stability | 16 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA118100 | University of New Mexico Cancer Center Support Grant | 9 | 2025 |
| R35GM147111 | DNA ligase activities during base excision repair coordination | 9 | 2025 |
| R01CA073764 | FEN1-mediated Okazaki fragment maturation and its deficiency in cancer | 8 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 7 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 6 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 6 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 6 | 2025 |
1 to 10 of 1,113Source NIH's project files
See all 1,113 nih grantsPapers1,551
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Dynamic view of an allosteric intermediate in a positively cooperative dimer. | bioRxiv | 2026 | 42798384 | PubTator, text mining | PubMed |
| Identification of Potential SARS-CoV-2 Main Protease (MPro) Inhibitors Through Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation Approaches. | Int J Mol Sci | 2026 | 42737581 | PubTator, text mining | PubMed |
| Comprehensive In Silico Analysis Identifies MSTO1 and LIG1 as Candidate Biomarkers With Diagnostic and Prognostic Relevance in Hepatocellular Carcinoma. | Cancer Rep (Hoboken) | 2026 | 42732946 | PubTator, text mining | PubMed |
| Integrated expression profiling of BCR-ABL and computational identification of ABL1 inhibitors in pediatric acute lymphoblastic leukemia. | In Silico Pharmacol | 2026 | 42707602 | PubTator, text mining | PubMed |
| Revealing the Association of LIG1 Genetic Variants With Pterygium Susceptibility and Demographic Characteristics in a Taiwanese Population. | In Vivo | 2026 | 42665426 | PubTator, text mining | PubMed |
| Cyclosporine Stabilized the Hemoglobin Level in Children With Novel Compound Heterozygous Mutations in the LIG1 Gene: A Single Case Report. | Pediatr Blood Cancer | 2026 | 42527943 | PubTator, text mining | PubMed |
| LIG1 Loss in TP53-mutant Triple Negative Breast Cancer Rewires DNA Repair and Confers Sensitivity to PARP-ATR Inhibitor Combinations. | Mol Cancer Ther | 2026 | 42456172 | PubTator, text mining | PubMed |
| Targeting LIG1 to overcome oxaliplatin resistance by inducing PANoptosis in colorectal cancer. | Drug Resist Updat | 2026 | 42442130 | PubTator, text mining | PubMed |
| Tissue-specific CTG•CAG expansion rate and disease severity are modified by DNA repair genes expression levels in myotonic dystrophy type 1 patients. | DNA Repair (Amst) | 2026 | 42419013 | PubTator, text mining | PubMed |
| RNA helicase DDX5 alleviates UVB-induced skin DNA damage through RBM15/METTL14-mediated m6A modification. | J Photochem Photobiol B | 2026 | 42296715 | PubTator, text mining | PubMed |
1 to 10 of 1,551
See all 1,551 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3978
GET https://conductscience.org/api/genes/v1/3978/patents?page=2