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Gene · 3978

LIG1: DNA ligase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LIG1: DNA ligase 1. Genes, record 3978. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3978

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Gene

Symbol
LIG1
HGNC
Name
DNA ligase 1
HGNC
NCBI Gene ID
3978
NCBI Gene
HGNC ID
HGNC:6598
HGNC
Ensembl
ENSG00000105486
NCBI Gene
Aliases
IMD96, LIGI, hLig1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18858DNA ligase 191935Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4780957 A12026-07-2966P18858Espacenet
EP 4709870 A12026-03-1856P18858Espacenet
EP 4650780 A22025-11-192189P18858Espacenet
EP 4641201 A22025-10-291755P18858Espacenet
EP 4641202 A22025-10-294560P18858Espacenet
JP 2025517969 A2025-06-121755P18858Espacenet
JP 2025517970 A2025-06-122189P18858Espacenet
KR 1020250017231 A2025-02-044560P18858Espacenet
JP 2024543481 A2024-11-2156P18858Espacenet
EP 4464338 A22024-11-20312P18858Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,113

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLIG1 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines342025
R01ES012512Roles of Lig3 and XRCC1 Genes in Genome Stability162025
P30CA016672Cancer Center Support Grant92025
P30CA118100University of New Mexico Cancer Center Support Grant92025
R35GM147111DNA ligase activities during base excision repair coordination92025
R01CA073764FEN1-mediated Okazaki fragment maturation and its deficiency in cancer82025
P30CA021765Cancer Center Support Grant (CCSG)72025
P30CA033572Cancer Center Support Grant62025
P30ES010126UNC Center for Environmental Health and Susceptibility62025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures62025

1 to 10 of 1,113Source NIH's project files

See all 1,113 nih grants

Papers1,551

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dynamic view of an allosteric intermediate in a positively cooperative dimer.bioRxiv202642798384PubTator, text miningPubMed
Identification of Potential SARS-CoV-2 Main Protease (MPro) Inhibitors Through Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation Approaches.Int J Mol Sci202642737581PubTator, text miningPubMed
Comprehensive In Silico Analysis Identifies MSTO1 and LIG1 as Candidate Biomarkers With Diagnostic and Prognostic Relevance in Hepatocellular Carcinoma.Cancer Rep (Hoboken)202642732946PubTator, text miningPubMed
Integrated expression profiling of BCR-ABL and computational identification of ABL1 inhibitors in pediatric acute lymphoblastic leukemia.In Silico Pharmacol202642707602PubTator, text miningPubMed
Revealing the Association of LIG1 Genetic Variants With Pterygium Susceptibility and Demographic Characteristics in a Taiwanese Population.In Vivo202642665426PubTator, text miningPubMed
Cyclosporine Stabilized the Hemoglobin Level in Children With Novel Compound Heterozygous Mutations in the LIG1 Gene: A Single Case Report.Pediatr Blood Cancer202642527943PubTator, text miningPubMed
LIG1 Loss in TP53-mutant Triple Negative Breast Cancer Rewires DNA Repair and Confers Sensitivity to PARP-ATR Inhibitor Combinations.Mol Cancer Ther202642456172PubTator, text miningPubMed
Targeting LIG1 to overcome oxaliplatin resistance by inducing PANoptosis in colorectal cancer.Drug Resist Updat202642442130PubTator, text miningPubMed
Tissue-specific CTG•CAG expansion rate and disease severity are modified by DNA repair genes expression levels in myotonic dystrophy type 1 patients.DNA Repair (Amst)202642419013PubTator, text miningPubMed
RNA helicase DDX5 alleviates UVB-induced skin DNA damage through RBM15/METTL14-mediated m6A modification.J Photochem Photobiol B202642296715PubTator, text miningPubMed

1 to 10 of 1,551

See all 1,551 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3978

GET https://conductscience.org/api/genes/v1/3978/patents?page=2