Gene · 3980
LIG3: DNA ligase 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LIG3: DNA ligase 3. Genes, record 3980. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3980
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49916 | DNA ligase 3 | 1,009 | 13 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4709870 A1 | 2026-03-18 | 59 | P49916 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10332 | P49916 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10332 | P49916 | Espacenet |
| JP 2024543481 A | 2024-11-21 | 59 | P49916 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 305 | P49916 | Espacenet |
| EP 4430207 A1 | 2024-09-18 | 59 | P49916 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6820 | P49916 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 305 | P49916 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 46605 | P49916 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 149576 | P49916 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,564
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LIG3 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 60 | 2025 |
| R01ES012512 | Roles of Lig3 and XRCC1 Genes in Genome Stability | 32 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P30CA118100 | University of New Mexico Cancer Center Support Grant | 14 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 13 | 2025 |
| R35ES031638 | Watching cooperative interactions between base and nucleotide excision repair proteins | 11 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| ZIAAG000723 | ALZHEIMERS RESEARCH PROJECT: DNA repair dysfunction in neurodegeneration and Alzheimer's Disease | 8 | 2025 |
| ZIABC006150 | DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs | 7 | 2025 |
1 to 10 of 1,564Source NIH's project files
See all 1,564 nih grantsPapers1,941
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of Potential SARS-CoV-2 Main Protease (MPro) Inhibitors Through Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation Approaches. | Int J Mol Sci | 2026 | 42737581 | PubTator, text mining | PubMed |
| Computer-aided drug design of quinoxaline based selective oestrogen receptor α modulators for breast cancer therapy: molecular docking, MD simulation, MM-PBSA and ADME/T analysis. | SAR QSAR Environ Res | 2026 | 42703730 | PubTator, text mining | PubMed |
| Mechanisms of PARP Inhibitor Resistance: From Replication Gap Biology and Transcription-Replication Conflicts to PROTAC-Based Next-Generation Strategies. | Environ Mol Mutagen | 2026 | 42590926 | PubTator, text mining | PubMed |
| Association of DNA damage response gene polymorphisms with treatment response and prognosis in acute myeloid leukemia. | J Cancer | 2026 | 42524324 | PubTator, text mining | PubMed |
| A DR5/Ligase 3-Mediated Feedback Loop Perpetuates Immunogenicity in Mismatch Repair Deficient Colorectal Cancer. | Gastroenterology | 2026 | 42462829 | PubTator, text mining | PubMed |
| Targeting WRN Helicase in Microsatellite-Instable Colorectal Cancer Induces Antitumor Immunity through Extrachromosomal Circular DNA Release. | Cancer Res | 2026 | 42461083 | PubTator, text mining | PubMed |
| Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets. | bioRxiv | 2026 | 42182287 | PubTator, text mining | PubMed |
| PARP1-mediated 5' flap dynamics facilitate Okazaki fragment maturation. | bioRxiv | 2026 | 42094445 | PubTator, text mining | PubMed |
| Genetic Markers of Tumor Multiplicity in Non-melanoma Skin Cancer: Associations of 19 SNPs in an Italian Cohort. | Dermatol Ther (Heidelb) | 2026 | 41964798 | PubTator, text mining | PubMed |
| Indel pattern-guided repair mapping reveals genome-wide DNA repair networks in CRISPR/Cas9 editing. | Nucleic Acids Res | 2026 | 41891877 | PubTator, text mining | PubMed |
1 to 10 of 1,941
See all 1,941 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3980
GET https://conductscience.org/api/genes/v1/3980/patents?page=2