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Gene · 3980

LIG3: DNA ligase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LIG3: DNA ligase 3. Genes, record 3980. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3980

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Gene

Symbol
LIG3
HGNC
Name
DNA ligase 3
HGNC
NCBI Gene ID
3980
NCBI Gene
HGNC ID
HGNC:6600
HGNC
Ensembl
ENSG00000005156
NCBI Gene
Aliases
LIG2, LIG3alpha, MTDPS20
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49916DNA ligase 31,00913Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4709870 A12026-03-1859P49916Espacenet
EP 4641201 A22025-10-2910332P49916Espacenet
JP 2025517969 A2025-06-1210332P49916Espacenet
JP 2024543481 A2024-11-2159P49916Espacenet
EP 4464338 A22024-11-20305P49916Espacenet
EP 4430207 A12024-09-1859P49916Espacenet
JP 2024123008 A2024-09-106820P49916Espacenet
US 11680268 B22023-06-20305P49916Espacenet
US 11446398 B22022-09-2046605P49916Espacenet
JP 2022524081 A2022-04-27149576P49916Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,564

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLIG3 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines602025
R01ES012512Roles of Lig3 and XRCC1 Genes in Genome Stability322025
P30CA016672Cancer Center Support Grant152025
P30CA118100University of New Mexico Cancer Center Support Grant142025
P30CA047904Cancer Center Support Grant132025
R35ES031638Watching cooperative interactions between base and nucleotide excision repair proteins112025
P30CA021765Cancer Center Support Grant (CCSG)102025
P30CA008748Cancer Center Support Grant82025
ZIAAG000723ALZHEIMERS RESEARCH PROJECT: DNA repair dysfunction in neurodegeneration and Alzheimer's Disease82025
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs72025

1 to 10 of 1,564Source NIH's project files

See all 1,564 nih grants

Papers1,941

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of Potential SARS-CoV-2 Main Protease (MPro) Inhibitors Through Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation Approaches.Int J Mol Sci202642737581PubTator, text miningPubMed
Computer-aided drug design of quinoxaline based selective oestrogen receptor α modulators for breast cancer therapy: molecular docking, MD simulation, MM-PBSA and ADME/T analysis.SAR QSAR Environ Res202642703730PubTator, text miningPubMed
Mechanisms of PARP Inhibitor Resistance: From Replication Gap Biology and Transcription-Replication Conflicts to PROTAC-Based Next-Generation Strategies.Environ Mol Mutagen202642590926PubTator, text miningPubMed
Association of DNA damage response gene polymorphisms with treatment response and prognosis in acute myeloid leukemia.J Cancer202642524324PubTator, text miningPubMed
A DR5/Ligase 3-Mediated Feedback Loop Perpetuates Immunogenicity in Mismatch Repair Deficient Colorectal Cancer.Gastroenterology202642462829PubTator, text miningPubMed
Targeting WRN Helicase in Microsatellite-Instable Colorectal Cancer Induces Antitumor Immunity through Extrachromosomal Circular DNA Release.Cancer Res202642461083PubTator, text miningPubMed
Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets.bioRxiv202642182287PubTator, text miningPubMed
PARP1-mediated 5' flap dynamics facilitate Okazaki fragment maturation.bioRxiv202642094445PubTator, text miningPubMed
Genetic Markers of Tumor Multiplicity in Non-melanoma Skin Cancer: Associations of 19 SNPs in an Italian Cohort.Dermatol Ther (Heidelb)202641964798PubTator, text miningPubMed
Indel pattern-guided repair mapping reveals genome-wide DNA repair networks in CRISPR/Cas9 editing.Nucleic Acids Res202641891877PubTator, text miningPubMed

1 to 10 of 1,941

See all 1,941 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3980

GET https://conductscience.org/api/genes/v1/3980/patents?page=2