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Gene · 3981

LIG4: DNA ligase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LIG4: DNA ligase 4. Genes, record 3981. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3981

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Gene

Symbol
LIG4
HGNC
Name
DNA ligase 4
HGNC
NCBI Gene ID
3981
NCBI Gene
HGNC ID
HGNC:6601
HGNC
Ensembl
ENSG00000174405
NCBI Gene
Aliases
LIG4S
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49917DNA ligase 491132Ensembl, GeneID, HGNC

Source UniProt

Patents72

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4780957 A12026-07-2965P49917Espacenet
EP 4709870 A12026-03-1863P49917Espacenet
EP 4650780 A22025-11-197368P49917Espacenet
EP 4641201 A22025-10-297313P49917Espacenet
JP 2025517969 A2025-06-127313P49917Espacenet
JP 2025517970 A2025-06-127368P49917Espacenet
JP 2024543481 A2024-11-2163P49917Espacenet
EP 4464338 A22024-11-20289P49917Espacenet
US 12146152 B22024-11-1990P49917Espacenet
EP 4430207 A12024-09-1863P49917Espacenet

1 to 10 of 72

See all 72 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,102

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLIG4 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines712025
P30CA008748Cancer Center Support Grant312025
R01ES012512Roles of Lig3 and XRCC1 Genes in Genome Stability232025
R35GM118009Site-Specific Recombination in Human Health & Disease192025
P30CA021765Cancer Center Support Grant (CCSG)162025
P30CA016672Cancer Center Support Grant152025
P30CA118100University of New Mexico Cancer Center Support Grant142025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN112025
R01CA097096DNA Polymerases in Nonhomologous End Joining102025
ZIABC010283DNA repair102025

1 to 10 of 2,102Source NIH's project files

See all 2,102 nih grants

Papers3,259

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical, immunological, and molecular characteristics of severe combined immune deficiency in China.Hum Genet202642799887PubTator, text miningPubMed
Integrated expression profiling of BCR-ABL and computational identification of ABL1 inhibitors in pediatric acute lymphoblastic leukemia.In Silico Pharmacol202642707602PubTator, text miningPubMed
LIG4 Syndrome Presenting with Extensive Cutaneous Viral Warts Caused by Multi-Type HPV Infection.Genes (Basel)202642650110PubTator, text miningPubMed
Identification and Preliminary Clinical Assessment of Key Genes Related to Endoplasmic Reticulum Stress and Autophagy in Minimal Change Disease.Genes (Basel)202642510787PubTator, text miningPubMed
The DNTTIP1-PARP1 interaction orchestrates MiDAC recruitment and activity for NHEJ-mediated genome stability.J Biol Chem202642463049PubTator, text miningPubMed
Human APOBEC3G suppresses homologous recombination and LIG4-independent end joining in DNA double-strand break repair.FEBS J202642403051PubTator, text miningPubMed
Non-syndromic premature ovarian insufficiency associated with monoallelic LIG4 mutation via haploinsufficiency.J Ovarian Res202642343416PubTator, text miningPubMed
Clinical and genetic landscape of SCID in Yunnan, China: identification of two novel RAG2 variants.Sci Rep202642209588PubTator, text miningPubMed
Lesions initiating spontaneous mitotic crossover are minimally subject to non-homologous end joining.bioRxiv202642182344PubTator, text miningPubMed
Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets.bioRxiv202642182287PubTator, text miningPubMed

1 to 10 of 3,259

See all 3,259 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3981

GET https://conductscience.org/api/genes/v1/3981/patents?page=2