Gene · 3981
LIG4: DNA ligase 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LIG4: DNA ligase 4. Genes, record 3981. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3981
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49917 | DNA ligase 4 | 911 | 32 | Ensembl, GeneID, HGNC |
Source UniProt
Patents72
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4780957 A1 | 2026-07-29 | 65 | P49917 | Espacenet |
| EP 4709870 A1 | 2026-03-18 | 63 | P49917 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7368 | P49917 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7313 | P49917 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7313 | P49917 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7368 | P49917 | Espacenet |
| JP 2024543481 A | 2024-11-21 | 63 | P49917 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 289 | P49917 | Espacenet |
| US 12146152 B2 | 2024-11-19 | 90 | P49917 | Espacenet |
| EP 4430207 A1 | 2024-09-18 | 63 | P49917 | Espacenet |
1 to 10 of 72
See all 72 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,102
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LIG4 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 71 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 31 | 2025 |
| R01ES012512 | Roles of Lig3 and XRCC1 Genes in Genome Stability | 23 | 2025 |
| R35GM118009 | Site-Specific Recombination in Human Health & Disease | 19 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 16 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P30CA118100 | University of New Mexico Cancer Center Support Grant | 14 | 2025 |
| P01CA096832 | NORMAL & NEOPLASTIC GROWTH IN THE BRAIN | 11 | 2025 |
| R01CA097096 | DNA Polymerases in Nonhomologous End Joining | 10 | 2025 |
| ZIABC010283 | DNA repair | 10 | 2025 |
1 to 10 of 2,102Source NIH's project files
See all 2,102 nih grantsPapers3,259
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Clinical, immunological, and molecular characteristics of severe combined immune deficiency in China. | Hum Genet | 2026 | 42799887 | PubTator, text mining | PubMed |
| Integrated expression profiling of BCR-ABL and computational identification of ABL1 inhibitors in pediatric acute lymphoblastic leukemia. | In Silico Pharmacol | 2026 | 42707602 | PubTator, text mining | PubMed |
| LIG4 Syndrome Presenting with Extensive Cutaneous Viral Warts Caused by Multi-Type HPV Infection. | Genes (Basel) | 2026 | 42650110 | PubTator, text mining | PubMed |
| Identification and Preliminary Clinical Assessment of Key Genes Related to Endoplasmic Reticulum Stress and Autophagy in Minimal Change Disease. | Genes (Basel) | 2026 | 42510787 | PubTator, text mining | PubMed |
| The DNTTIP1-PARP1 interaction orchestrates MiDAC recruitment and activity for NHEJ-mediated genome stability. | J Biol Chem | 2026 | 42463049 | PubTator, text mining | PubMed |
| Human APOBEC3G suppresses homologous recombination and LIG4-independent end joining in DNA double-strand break repair. | FEBS J | 2026 | 42403051 | PubTator, text mining | PubMed |
| Non-syndromic premature ovarian insufficiency associated with monoallelic LIG4 mutation via haploinsufficiency. | J Ovarian Res | 2026 | 42343416 | PubTator, text mining | PubMed |
| Clinical and genetic landscape of SCID in Yunnan, China: identification of two novel RAG2 variants. | Sci Rep | 2026 | 42209588 | PubTator, text mining | PubMed |
| Lesions initiating spontaneous mitotic crossover are minimally subject to non-homologous end joining. | bioRxiv | 2026 | 42182344 | PubTator, text mining | PubMed |
| Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets. | bioRxiv | 2026 | 42182287 | PubTator, text mining | PubMed |
1 to 10 of 3,259
See all 3,259 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3981
GET https://conductscience.org/api/genes/v1/3981/patents?page=2