Gene · 3984
LIMK1: LIM domain kinase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LIMK1: LIM domain kinase 1. Genes, record 3984. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3984
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P53667 | LIM domain kinase 1 | 647 | 10 | Ensembl, GeneID, HGNC |
Source UniProt
Patents41
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 6215 | P53667 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6215 | P53667 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 13481 | P53667 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6824 | P53667 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6825 | P53667 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 46756 | P53667 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 149727 | P53667 | Espacenet |
| US 10501513 B2 | 2019-12-10 | 6824 | P53667 | Espacenet |
| US 10501513 B2 | 2019-12-10 | 6825 | P53667 | Espacenet |
| US 9827332 B2 | 2017-11-28 | 13481 | P53667 | Espacenet |
1 to 10 of 41
See all 41 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,561
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LIMK1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 7 | 2025 |
| R01GM102262 | LIM domain kinases: regulation and substrate recognition | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| R01GM086858 | New Molecular Probes For Protein Kinases | 5 | 2025 |
| T32NS061788 | UAB Research Training Program in Neurobiology of Cognition and Cognitive Disorders | 4 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 3 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P50CA116201 | Mayo Clinic Breast Cancer SPORE | 3 | 2025 |
| R01AG061800 | Identifying therapeutic targets that confer synaptic resilience to Alzheimer's disease | 3 | 2025 |
1 to 10 of 1,561Source NIH's project files
See all 1,561 nih grantsPapers2,724
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Correction: NECTIN2 depletion impairs migration and invasion in MDA-MB-231 breast cancer cells through LIMK1-associated cytoskeletal remodeling. | PLoS One | 2026 | 42789498 | PubTator, text mining | PubMed |
| Ginsenoside Rb1 protects hair cell-like HEI-OC1 cells against apoptosis by inhibiting the activation of the Fas system induced by the RhoA/ROCK/LIMK1 pathway. | Daru | 2026 | 42700190 | PubTator, text mining | PubMed |
| NECTIN2 depletion impairs migration and invasion in MDA-MB-231 breast cancer cells through LIMK1-associated cytoskeletal remodeling. | PLoS One | 2026 | 42664293 | PubTator, text mining | PubMed |
| LIMK1 and PKM as Integratively Identified Transcriptomic Signatures in Inflammatory Bowel Disease. | OMICS | 2026 | 42584099 | PubTator, text mining | PubMed |
[Unveiling efficacy targets and differentiated mechanisms of Colquhounia Root Tablets in "homotherapy for heteropathy" of rheumatoid arthritis and diabetic kidney disease: a analysis based on topological feature identification and path priority assessment]. | Zhongguo Zhong Yao Za Zhi | 2026 | 42543287 | PubTator, text mining | PubMed |
| PAK4 in the Tumor Immune Microenvironment: Biological Functions, Regulatory Mechanisms, and Targeted Therapeutic Strategies. | Med Res Rev | 2026 | 42489806 | PubTator, text mining | PubMed |
| A covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2. | J Biol Chem | 2026 | 42442493 | PubTator, text mining | PubMed |
| Extracellular Pgk1 or Its Derived Short Peptide Interacted with Membrane-Associated Enolase 2 Receptor: A Potential Therapy for ALS Motor Neuron Degeneration. | Biomolecules | 2026 | 42352358 | PubTator, text mining | PubMed |
| N6-methyladenosine modification of CBLB affects LPS-induced endoplasmic reticulum stress in alveolar epithelial cells. | Cent Eur J Immunol | 2026 | 42245124 | PubTator, text mining | PubMed |
| Co-overexpression of ELOVL2 and ELOVL5 promotes clear cell renal cell carcinoma progression through LIMK1-mediated cytoskeletal reorganization. | Sci Rep | 2026 | 42225919 | PubTator, text mining | PubMed |
1 to 10 of 2,724
See all 2,724 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3984
GET https://conductscience.org/api/genes/v1/3984/patents?page=2