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Gene · 3984

LIMK1: LIM domain kinase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LIMK1: LIM domain kinase 1. Genes, record 3984. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3984

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Gene

Symbol
LIMK1
HGNC
Name
LIM domain kinase 1
HGNC
NCBI Gene ID
3984
NCBI Gene
HGNC ID
HGNC:6613
HGNC
Ensembl
ENSG00000106683
NCBI Gene
Aliases
LIMK, LIMK-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P53667LIM domain kinase 164710Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196215P53667Espacenet
JP 2025517970 A2025-06-126215P53667Espacenet
JP 2025024198 A2025-02-1913481P53667Espacenet
JP 2024123008 A2024-09-106824P53667Espacenet
JP 2024123008 A2024-09-106825P53667Espacenet
US 11446398 B22022-09-2046756P53667Espacenet
JP 2022524081 A2022-04-27149727P53667Espacenet
US 10501513 B22019-12-106824P53667Espacenet
US 10501513 B22019-12-106825P53667Espacenet
US 9827332 B22017-11-2813481P53667Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,561

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLIMK1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P30CA006927Comprehensive Cancer Center Program at Fox Chase72025
R01GM102262LIM domain kinases: regulation and substrate recognition62025
P30CA008748Cancer Center Support Grant52025
R01GM086858New Molecular Probes For Protein Kinases52025
T32NS061788UAB Research Training Program in Neurobiology of Cognition and Cognitive Disorders42025
P30CA016058Cancer Center Support Grant32025
P30CA030199Cancer Center Support Grant (CCSG)32025
P50CA116201Mayo Clinic Breast Cancer SPORE32025
R01AG061800Identifying therapeutic targets that confer synaptic resilience to Alzheimer's disease32025

1 to 10 of 1,561Source NIH's project files

See all 1,561 nih grants

Papers2,724

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Correction: NECTIN2 depletion impairs migration and invasion in MDA-MB-231 breast cancer cells through LIMK1-associated cytoskeletal remodeling.PLoS One202642789498PubTator, text miningPubMed
Ginsenoside Rb1 protects hair cell-like HEI-OC1 cells against apoptosis by inhibiting the activation of the Fas system induced by the RhoA/ROCK/LIMK1 pathway.Daru202642700190PubTator, text miningPubMed
NECTIN2 depletion impairs migration and invasion in MDA-MB-231 breast cancer cells through LIMK1-associated cytoskeletal remodeling.PLoS One202642664293PubTator, text miningPubMed
LIMK1 and PKM as Integratively Identified Transcriptomic Signatures in Inflammatory Bowel Disease.OMICS202642584099PubTator, text miningPubMed
[Unveiling efficacy targets and differentiated mechanisms of Colquhounia Root Tablets in "homotherapy for heteropathy" of rheumatoid arthritis and diabetic kidney disease: a analysis based on topological feature identification and path priority assessment].
Zhongguo Zhong Yao Za Zhi202642543287PubTator, text miningPubMed
PAK4 in the Tumor Immune Microenvironment: Biological Functions, Regulatory Mechanisms, and Targeted Therapeutic Strategies.Med Res Rev202642489806PubTator, text miningPubMed
A covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2.J Biol Chem202642442493PubTator, text miningPubMed
Extracellular Pgk1 or Its Derived Short Peptide Interacted with Membrane-Associated Enolase 2 Receptor: A Potential Therapy for ALS Motor Neuron Degeneration.Biomolecules202642352358PubTator, text miningPubMed
N6-methyladenosine modification of CBLB affects LPS-induced endoplasmic reticulum stress in alveolar epithelial cells.Cent Eur J Immunol202642245124PubTator, text miningPubMed
Co-overexpression of ELOVL2 and ELOVL5 promotes clear cell renal cell carcinoma progression through LIMK1-mediated cytoskeletal reorganization.Sci Rep202642225919PubTator, text miningPubMed

1 to 10 of 2,724

See all 2,724 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3984

GET https://conductscience.org/api/genes/v1/3984/patents?page=2