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LIPA: lipase A, lysosomal acid type

1 protein, 180 patents, 0 drugs, 0 trials, 2,145 NIH grants and 4,595 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLIPAHGNC
Namelipase A, lysosomal acid typeHGNC
NCBI Gene ID3988NCBI Gene
HGNC IDHGNC:6617HGNC
EnsemblENSG00000107798NCBI Gene
AliasesCESD, LALNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P38571Lysosomal acid lipase/cholesteryl ester hydrolase3991Ensembl, GeneID, HGNCUniProt

Patents 180

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026519297 A2026-06-152P38571Espacenet
JP 2026067851 A2026-04-21140P38571Espacenet
EP 4705273 A22026-03-11520P38571Espacenet
WO 2026028089 A12026-02-054P38571Espacenet
EP 4650780 A22025-11-196264P38571Espacenet
JP 2025169942 A2025-11-141128P38571Espacenet
JP 2025169942 A2025-11-141130P38571Espacenet
JP 2025169942 A2025-11-141134P38571Espacenet
JP 2025169942 A2025-11-141136P38571Espacenet
JP 2025147176 A2025-10-067897P38571Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2145

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK020579Diabetes Research Center112,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center102,025NIH's project files
R01HL125838Sensing and Clearance of Damaged Lysosomes in Macrophages and Atherosclerosis92,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)82,025NIH's project files
R01HL093324Macrophage-Lipoprotein Interactions82,025NIH's project files
I01BX003415Harnessing the Autophagy-Lysosomal Biogenesis Response in Macrophages to Treat Atherosclerosis62,025NIH's project files
P30CA082709Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant62,025NIH's project files
UL1TR001873Clinical and Translational Science Award62,025NIH's project files
R01DK062292Analysis of Cellular Plasticity in White Adipose Tissue.52,025NIH's project files
R01DK067859Development of Assays for Newborn Screening and for Post-Screening Evaluation of Disease Severity52,025NIH's project files

Papers 4595

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42784530PubTator, text miningPubMed
42768761PubTator, text miningPubMed
42733995PubTator, text miningPubMed
42694416PubTator, text miningPubMed
42644915PubTator, text miningPubMed
42620441PubTator, text miningPubMed
42618035PubTator, text miningPubMed
42570019PubTator, text miningPubMed
42569310PubTator, text miningPubMed
42567485PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license