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Gene · 3992

FADS1: fatty acid desaturase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FADS1: fatty acid desaturase 1. Genes, record 3992. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3992

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Gene

Symbol
FADS1
HGNC
Name
fatty acid desaturase 1
HGNC
NCBI Gene ID
3992
NCBI Gene
HGNC ID
HGNC:3574
HGNC
Ensembl
ENSG00000149485
NCBI Gene
Aliases
D5D, FADS6, FADSD5, LLCDL1, TU12
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O60427Acyl-CoA (8-3)-desaturase4440Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1940960O60427Espacenet
JP 2025529142 A2025-09-041472O60427Espacenet
US 12371689 B22025-07-291472O60427Espacenet
JP 2025517970 A2025-06-1240960O60427Espacenet
WO 2017167821 A12017-10-0527O60427Espacenet
US 8815566 B22014-08-2612O60427Espacenet
US 8685682 B22014-04-0112O60427Espacenet
US 8586006 B22013-11-199803O60427Espacenet
US 8518674 B22013-08-2712O60427Espacenet
US 8241884 B22012-08-1461O60427Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,896

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFADS1 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)252025
P30DK020572Michigan Diabetes Research Center (MDRC)142025
ZIAHG000024Genetic analysis of type II diabetes102025
ZIAAG000965The Aging Genome Association Study "AGE-GAIN"82025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal72025
P30CA016672Cancer Center Support Grant62025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital62025
P30DK089503Michigan Nutrition Obesity Research Center62025
UL1TR001881UCLA Clinical and Translational Science Institute62025
UL1TR002243Vanderbilt Institute for Clinical and Translational Research (VICTR)62025

1 to 10 of 1,896Source NIH's project files

See all 1,896 nih grants

Papers2,732

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Luteolin-7-O-rutinoside-enriched aloe vera rind-derived nanoparticles attenuate skin photoaging by restoring FADS1-mediated fatty acid metabolism.Phytomedicine202642826557PubTator, text miningPubMed
Effects of the FADS1 rs174537 polymorphism on polyunsaturated fatty acid levels in human tissues: a systematic review.Crit Rev Food Sci Nutr202642808684PubTator, text miningPubMed
Runs of Homozygosity and Signatures of Positive Selection in Colombian Native American Populations: Genetic Architecture and Demographic History.Am J Biol Anthropol202642802603PubTator, text miningPubMed
Genome-wide association study of patterns of perinatal exposure to polyunsaturated fatty acids from the EDEN mother-child cohort.Prostaglandins Leukot Essent Fatty Acids202642753583PubTator, text miningPubMed
Integrated Metabolomic and Genetic Profiling Implicates Loss of Docosahexaenoic Acid in the Link Between Ultraprocessed Foods and Crohn's Disease.Clin Gastroenterol Hepatol202642749102PubTator, text miningPubMed
From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn's disease.PLoS One202642726709PubTator, text miningPubMed
Correction: Cardiometabolic risk factors are affected by interaction between FADS1 rs174556 variant and dietary vegetable oils in patients with diabetes: a randomized controlled trial.Sci Rep202642722698PubTator, text miningPubMed
The FADS insertion-deletion polymorphism drives the arachidonic acid/dihomo-gamma-linolenic acid ratio in preterm infants and may contribute to patency of ductus arteriosus - a pilot study.Prostaglandins Leukot Essent Fatty Acids202642697009PubTator, text miningPubMed
Ethnicity and antenatal maternal anxiety: associations with the human milk lipidome in a multi-ethnic Asian cohort.Front Nutr202642694327PubTator, text miningPubMed
Effect of a 6-month low-carbohydrate diet on the circulating fatty acid composition in patients with type 2 diabetes: a secondary analysis of an open-label randomized controlled trial.Am J Clin Nutr202642680257PubTator, text miningPubMed

1 to 10 of 2,732

See all 2,732 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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