Gene · 3992
FADS1: fatty acid desaturase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FADS1: fatty acid desaturase 1. Genes, record 3992. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3992
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O60427 | Acyl-CoA (8-3)-desaturase | 444 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents41
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 40960 | O60427 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1472 | O60427 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1472 | O60427 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 40960 | O60427 | Espacenet |
| WO 2017167821 A1 | 2017-10-05 | 27 | O60427 | Espacenet |
| US 8815566 B2 | 2014-08-26 | 12 | O60427 | Espacenet |
| US 8685682 B2 | 2014-04-01 | 12 | O60427 | Espacenet |
| US 8586006 B2 | 2013-11-19 | 9803 | O60427 | Espacenet |
| US 8518674 B2 | 2013-08-27 | 12 | O60427 | Espacenet |
| US 8241884 B2 | 2012-08-14 | 61 | O60427 | Espacenet |
1 to 10 of 41
See all 41 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,896
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FADS1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK063491 | Diabetes Research Center (DRC) | 25 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 14 | 2025 |
| ZIAHG000024 | Genetic analysis of type II diabetes | 10 | 2025 |
| ZIAAG000965 | The Aging Genome Association Study "AGE-GAIN" | 8 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 6 | 2025 |
| P30DK089503 | Michigan Nutrition Obesity Research Center | 6 | 2025 |
| UL1TR001881 | UCLA Clinical and Translational Science Institute | 6 | 2025 |
| UL1TR002243 | Vanderbilt Institute for Clinical and Translational Research (VICTR) | 6 | 2025 |
1 to 10 of 1,896Source NIH's project files
See all 1,896 nih grantsPapers2,732
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Luteolin-7-O-rutinoside-enriched aloe vera rind-derived nanoparticles attenuate skin photoaging by restoring FADS1-mediated fatty acid metabolism. | Phytomedicine | 2026 | 42826557 | PubTator, text mining | PubMed |
| Effects of the FADS1 rs174537 polymorphism on polyunsaturated fatty acid levels in human tissues: a systematic review. | Crit Rev Food Sci Nutr | 2026 | 42808684 | PubTator, text mining | PubMed |
| Runs of Homozygosity and Signatures of Positive Selection in Colombian Native American Populations: Genetic Architecture and Demographic History. | Am J Biol Anthropol | 2026 | 42802603 | PubTator, text mining | PubMed |
| Genome-wide association study of patterns of perinatal exposure to polyunsaturated fatty acids from the EDEN mother-child cohort. | Prostaglandins Leukot Essent Fatty Acids | 2026 | 42753583 | PubTator, text mining | PubMed |
| Integrated Metabolomic and Genetic Profiling Implicates Loss of Docosahexaenoic Acid in the Link Between Ultraprocessed Foods and Crohn's Disease. | Clin Gastroenterol Hepatol | 2026 | 42749102 | PubTator, text mining | PubMed |
| From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn's disease. | PLoS One | 2026 | 42726709 | PubTator, text mining | PubMed |
| Correction: Cardiometabolic risk factors are affected by interaction between FADS1 rs174556 variant and dietary vegetable oils in patients with diabetes: a randomized controlled trial. | Sci Rep | 2026 | 42722698 | PubTator, text mining | PubMed |
| The FADS insertion-deletion polymorphism drives the arachidonic acid/dihomo-gamma-linolenic acid ratio in preterm infants and may contribute to patency of ductus arteriosus - a pilot study. | Prostaglandins Leukot Essent Fatty Acids | 2026 | 42697009 | PubTator, text mining | PubMed |
| Ethnicity and antenatal maternal anxiety: associations with the human milk lipidome in a multi-ethnic Asian cohort. | Front Nutr | 2026 | 42694327 | PubTator, text mining | PubMed |
| Effect of a 6-month low-carbohydrate diet on the circulating fatty acid composition in patients with type 2 diabetes: a secondary analysis of an open-label randomized controlled trial. | Am J Clin Nutr | 2026 | 42680257 | PubTator, text mining | PubMed |
1 to 10 of 2,732
See all 2,732 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3992
GET https://conductscience.org/api/genes/v1/3992/patents?page=2