Gene · 40
ASIC2: acid sensing ion channel subunit 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ASIC2: acid sensing ion channel subunit 2. Genes, record 40. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/40
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16515 | Acid-sensing ion channel 2 | 512 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37192 | Q16515 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 464 | Q16515 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 464 | Q16515 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 1357 | Q16515 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24857 | Q16515 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 24857 | Q16515 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 24857 | Q16515 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 1357 | Q16515 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 104328 | Q16515 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 844 | Q16515 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants480
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ASIC2 papers | Newest fiscal year |
|---|---|---|---|
| T32HL105324 | Hypertension and Cardiorenal Research Training Program | 3 | 2025 |
| ZIACP010131 | Studies of Populations Exposed to Therapeutic Medical Radiation and Other Agents | 3 | 2025 |
| P30GM149404 | Cardiorenal and Metabolic Diseases Research Center | 2 | 2025 |
| T32MH020030 | ResearchTraining: Psychiatric and Statistical Genetics | 2 | 2025 |
| T32NS045549 | Interdisciplinary Training Program in Pain Research | 2 | 2025 |
| U19AG023122 | Longevity Consortium | 2 | 2025 |
| DP1DA054394 | Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction | 1 | 2025 |
| I01BX004440 | Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior | 1 | 2025 |
| I01BX004820 | Genetic Vulnerability for Sustained Multi-Substance Use in MVP | 1 | 2025 |
| K01AA030083 | Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches | 1 | 2025 |
1 to 10 of 480Source NIH's project files
See all 480 nih grantsPapers705
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Associations of ASIC2, IKZF3, and GSDMB Variants with Gestational Diabetes Mellitus and Their Interactions with Environmental Exposures Among Chinese Women. | Biomolecules | 2026 | 42793205 | PubTator, text mining | PubMed |
| Exploratory Immunohistochemical Mapping of Mechanosensitivity-Associated Ion Channel Proteins in Terminal Glial Cells of Human Meissner and Pacinian Corpuscles. | Int J Mol Sci | 2026 | 42511862 | PubTator, text mining | PubMed |
| Acid-sensing ion channels in the vasculature: emerging roles in systemic and pulmonary circulations. | Pflugers Arch | 2026 | 42437803 | PubTator, text mining | PubMed |
| Evolutionary Restructuring and Systematic Review of the NBPF Gene Family: Comparative Genomics, Functional Divergence, and Disease-Linked Pathways. | J Dev Biol | 2026 | 41892808 | PubTator, text mining | PubMed |
| High ASIC3 Expression Correlates with Poor Prognosis in Lung Cancer Patients and Mediates Hypercapnic Acidosis-Induced EMT in A549 Cells. | Technol Cancer Res Treat | 2026 | 41854360 | PubTator, text mining | PubMed |
| Lipid Regulation of Mechanosensitive Ion Channels. | Int J Mol Sci | 2026 | 41752117 | PubTator, text mining | PubMed |
| Nonsense Mutation in USH2A Exon-13 Activates the Innate Immune Response in Müller Glial Cells. | Int J Mol Sci | 2026 | 41751772 | PubTator, text mining | PubMed |
| Exploring the Pain-Relieving Potential: Unveiling Antinociceptive Properties in Animal Venoms and Toxins. | Toxins (Basel) | 2026 | 41745735 | PubTator, text mining | PubMed |
| Mechanism of ASIC4 in regulating MHC-I-mediated immune evasion in pancreatic cancer. | J Transl Med | 2026 | 41736094 | PubTator, text mining | PubMed |
| A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia. | bioRxiv | 2026 | 41726865 | PubTator, text mining | PubMed |
1 to 10 of 705
See all 705 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/40
GET https://conductscience.org/api/genes/v1/40/patents?page=2