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Gene · 40

ASIC2: acid sensing ion channel subunit 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ASIC2: acid sensing ion channel subunit 2. Genes, record 40. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/40

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Gene

Symbol
ASIC2
HGNC
Name
acid sensing ion channel subunit 2
HGNC
NCBI Gene ID
40
NCBI Gene
HGNC ID
HGNC:99
HGNC
Ensembl
ENSG00000108684
NCBI Gene
Aliases
ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16515Acid-sensing ion channel 25121Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437192Q16515Espacenet
JP 2025529142 A2025-09-04464Q16515Espacenet
US 12371689 B22025-07-29464Q16515Espacenet
JP 2025062604 A2025-04-141357Q16515Espacenet
JP 2025032204 A2025-03-1124857Q16515Espacenet
EP 4461818 A22024-11-1324857Q16515Espacenet
JP 2023058610 A2023-04-2524857Q16515Espacenet
US 11446398 B22022-09-201357Q16515Espacenet
JP 2022524081 A2022-04-27104328Q16515Espacenet
US 11078247 B22021-08-03844Q16515Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants480

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleASIC2 papersNewest fiscal year
T32HL105324Hypertension and Cardiorenal Research Training Program32025
ZIACP010131Studies of Populations Exposed to Therapeutic Medical Radiation and Other Agents32025
P30GM149404Cardiorenal and Metabolic Diseases Research Center22025
T32MH020030ResearchTraining: Psychiatric and Statistical Genetics22025
T32NS045549Interdisciplinary Training Program in Pain Research22025
U19AG023122Longevity Consortium22025
DP1DA054394Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction12025
I01BX004440Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior12025
I01BX004820Genetic Vulnerability for Sustained Multi-Substance Use in MVP12025
K01AA030083Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches12025

1 to 10 of 480Source NIH's project files

See all 480 nih grants

Papers705

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Associations of ASIC2, IKZF3, and GSDMB Variants with Gestational Diabetes Mellitus and Their Interactions with Environmental Exposures Among Chinese Women.Biomolecules202642793205PubTator, text miningPubMed
Exploratory Immunohistochemical Mapping of Mechanosensitivity-Associated Ion Channel Proteins in Terminal Glial Cells of Human Meissner and Pacinian Corpuscles.Int J Mol Sci202642511862PubTator, text miningPubMed
Acid-sensing ion channels in the vasculature: emerging roles in systemic and pulmonary circulations.Pflugers Arch202642437803PubTator, text miningPubMed
Evolutionary Restructuring and Systematic Review of the NBPF Gene Family: Comparative Genomics, Functional Divergence, and Disease-Linked Pathways.J Dev Biol202641892808PubTator, text miningPubMed
High ASIC3 Expression Correlates with Poor Prognosis in Lung Cancer Patients and Mediates Hypercapnic Acidosis-Induced EMT in A549 Cells.Technol Cancer Res Treat202641854360PubTator, text miningPubMed
Lipid Regulation of Mechanosensitive Ion Channels.Int J Mol Sci202641752117PubTator, text miningPubMed
Nonsense Mutation in USH2A Exon-13 Activates the Innate Immune Response in Müller Glial Cells.Int J Mol Sci202641751772PubTator, text miningPubMed
Exploring the Pain-Relieving Potential: Unveiling Antinociceptive Properties in Animal Venoms and Toxins.Toxins (Basel)202641745735PubTator, text miningPubMed
Mechanism of ASIC4 in regulating MHC-I-mediated immune evasion in pancreatic cancer.J Transl Med202641736094PubTator, text miningPubMed
A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia.bioRxiv202641726865PubTator, text miningPubMed

1 to 10 of 705

See all 705 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/40

GET https://conductscience.org/api/genes/v1/40/patents?page=2