ConductScience.org, home

Gene · 4012

LNPEP: leucyl and cystinyl aminopeptidase

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. LNPEP: leucyl and cystinyl aminopeptidase. Genes, record 4012. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4012

On this page

Gene

Symbol
LNPEP
HGNC
Name
leucyl and cystinyl aminopeptidase
HGNC
NCBI Gene ID
4012
NCBI Gene
HGNC ID
HGNC:6656
HGNC
Ensembl
ENSG00000113441
NCBI Gene
Aliases
CAP, IRAP, P-LAP, PLAP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UIQ6Leucyl-cystinyl aminopeptidase1,02511Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026063308 A2026-03-2641Q9UIQ6Espacenet
JP 2026004568 A2026-01-1451410Q9UIQ6Espacenet
EP 4650780 A22025-11-19801Q9UIQ6Espacenet
EP 4641201 A22025-10-29567Q9UIQ6Espacenet
JP 2025529142 A2025-09-042402Q9UIQ6Espacenet
US 12371689 B22025-07-292402Q9UIQ6Espacenet
JP 2025517969 A2025-06-12567Q9UIQ6Espacenet
JP 2025517970 A2025-06-12801Q9UIQ6Espacenet
JP 2024543981 A2024-11-261Q9UIQ6Espacenet
US 11446398 B22022-09-2046007Q9UIQ6Espacenet

1 to 10 of 41

See all 41 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
TOSEDOSTATCHEMBL2103847Aminopeptidase inhibitorINHIBITOR

Source ChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02452346TOSEDOSTATPHASE22018-06-12ClinicalTrials.gov
NCT02352831TOSEDOSTATPHASE1/PHASE22018-12-17ClinicalTrials.gov
NCT01636609TOSEDOSTATPHASE1ClinicalTrials.gov
NCT01567059TOSEDOSTATPHASE2ClinicalTrials.gov
NCT01180426TOSEDOSTATPHASE2ClinicalTrials.gov
NCT00780598TOSEDOSTATPHASE2ClinicalTrials.gov
NCT00737555TOSEDOSTATPHASE1ClinicalTrials.gov
NCT00689000TOSEDOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT00522938TOSEDOSTATPHASE1/PHASE2ClinicalTrials.gov

NIH grants801

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLNPEP papersNewest fiscal year
P30DK045735Yale Diabetes Research Center62025
R01DK067299Novel Roles and Mechanisms of Proximal Tubule Mitochondrial Angiotensin II and Sirtuin 3 in Hypertension52025
ZIAHG000024Genetic analysis of type II diabetes52025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits42025
P30DK034854Integrated Epithelial and Muscosal Biology32025
P30DK063491Diabetes Research Center (DRC)32025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION32025
R01DK129466Vesicle Translocation and the Metabolic Syndrome32025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition32025

1 to 10 of 801Source NIH's project files

See all 801 nih grants

Papers1,729

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pregnancy-unmasked latent autoimmune arginine vasopressin deficiency with anti-rabphilin-3a antibody positivity.JCEM Case Rep202642775170PubTator, text miningPubMed
Systematic Integration of genomics with transcriptomics for the Study of Coronary Artery Disease and Subclinical Atherosclerosis.medRxiv202642620441PubTator, text miningPubMed
[Pregnancy and thirst, a remarkable duo].Ned Tijdschr Geneeskd202642565304PubTator, text miningPubMed
Leveraging expression quantitative trait loci information in single-cell resolution to identify cell-specific genes for gestational diabetes.PLoS One202642531322PubTator, text miningPubMed
Comprehensive Driver Mutation Landscape of DLBCL Informed by Integrated Tissue and Circulating DNA Analyses.Cancer Res Treat202642526849PubTator, text miningPubMed
Erratum: Role of insulin-regulated aminopeptidase as potential biomarker in insulin resistant polycystic ovary syndrome patients.Arch Endocrinol Metab202642429690PubTator, text miningPubMed
Dexamethasone as a Modulator of Renin-Angiotensin System Receptor Expression in Prostate and Ovarian Cancer Cells Under Standard and Low-Serum Conditions.Cancers (Basel)202642352530PubTator, text miningPubMed
Dual Aetiology of Diabetes Insipidus in Pregnancy: Vasopressinase-Mediated and Central Mechanisms.Case Rep Nephrol202642327372PubTator, text miningPubMed
Functional and computational interrogation of juvenile idiopathic arthritis risk loci in CD4+ T cells.HGG Adv202642057421PubTator, text miningPubMed
Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart.Cell Mol Life Sci202641886090PubTator, text miningPubMed

1 to 10 of 1,729

See all 1,729 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4012

GET https://conductscience.org/api/genes/v1/4012/patents?page=2