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Gene · 4014

LORICRIN: loricrin cornified envelope precursor protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LORICRIN: loricrin cornified envelope precursor protein. Genes, record 4014. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4014

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Gene

Symbol
LORICRIN
HGNC
Name
loricrin cornified envelope precursor protein
HGNC
NCBI Gene ID
4014
NCBI Gene
HGNC ID
HGNC:6663
HGNC
Ensembl
ENSG00000203782
NCBI Gene
Aliases
LOR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P23490Loricrin3120Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082974 A2026-05-19132P23490Espacenet
JP 2026004568 A2026-01-1451910P23490Espacenet
US 12275780 B22025-04-1542P23490Espacenet
JP 2022546545 A2022-11-04134P23490Espacenet
US 11446398 B22022-09-2047181P23490Espacenet
JP 2022524081 A2022-04-27150152P23490Espacenet
US 11078247 B22021-08-036288P23490Espacenet
WO 2021046131 A12021-03-11132P23490Espacenet
WO 2020099828 A12020-05-2242P23490Espacenet
WO 2020099829 A12020-05-2242P23490Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants868

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLORICRIN papersNewest fiscal year
R01AR041836Function of Desmoglein 1/Pemphigus Foliaceus Antigen82025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center72025
R01AR066530Regulators of epidermal growth and differentiation72025
P30AR075047Skin Biology Resource-Based Center at UCI62025
P30AR075049Northwestern University Skin Biology and Diseases Resource-based Center62025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
R01AR045192REGULATORS OF EPIDERMAL GENE EXPRESSION62025
T32CA009302Leveraging innovative technologies in basic and clinical cancer research62025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success62025
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer52025

1 to 10 of 868Source NIH's project files

See all 868 nih grants

Papers2,126

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Anoectochilus roxburghii extract alleviates inflammation and restores skin barrier function in vitro and in vivo.Fitoterapia202642800590PubTator, text miningPubMed
ML281 Does Not Function as an STK33 Inhibitor but Modulates Proliferation and Differentiation of Keratinocytes Derived from Hypertrophic Scars.Int J Mol Sci202642794700PubTator, text miningPubMed
Lipoic acid synthase modulates psoriasis-like keratinocyte dysfunction in association with oxidative stress, ferroptosis-associated remodeling, and STAT3/NF-κB activation.Naunyn Schmiedebergs Arch Pharmacol202642776206PubTator, text miningPubMed
Characterization of epidermal and dermal remodeling following skin injury by sulfur mustard in Göttingen minipigs.Cutan Ocul Toxicol202642632083PubTator, text miningPubMed
Comparative analysis of candidate gene expression in Asian atopic dermatitis and psoriasis: identification of shared and distinct molecular features.Front Med (Lausanne)202642614128PubTator, text miningPubMed
Multi-omics integration of gut-skin axis in probiotic-treated dermatological conditions.Front Cell Infect Microbiol202642516436PubTator, text miningPubMed
Translational Assessment of a Cell-Penetrating Peptide Topical Formulation for Repairing Barrier Dysfunction in Human Skin.Int J Mol Sci202642511700PubTator, text miningPubMed
Jaungo-based herbal complex regulates psoriasis-associated macrophage-keratinocyte inflammatory axis.Front Pharmacol202642482777PubTator, text miningPubMed
Interface-engineered supramolecular collagen peptide nanocapsules for barrier repair and matrix remodeling: From molecular assembly to clinical translation.J Control Release202642480655PubTator, text miningPubMed
The LCE3D/TGF-β1 Axis in atopic dermatitis: Expression profiling, clinical significance, and mechanistic insights into epithelial-immune crosstalk.Clin Immunol202642435926PubTator, text miningPubMed

1 to 10 of 2,126

See all 2,126 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4014

GET https://conductscience.org/api/genes/v1/4014/patents