Gene · 4014
LORICRIN: loricrin cornified envelope precursor protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LORICRIN: loricrin cornified envelope precursor protein. Genes, record 4014. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4014
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P23490 | Loricrin | 312 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026082974 A | 2026-05-19 | 132 | P23490 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 51910 | P23490 | Espacenet |
| US 12275780 B2 | 2025-04-15 | 42 | P23490 | Espacenet |
| JP 2022546545 A | 2022-11-04 | 134 | P23490 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 47181 | P23490 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 150152 | P23490 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 6288 | P23490 | Espacenet |
| WO 2021046131 A1 | 2021-03-11 | 132 | P23490 | Espacenet |
| WO 2020099828 A1 | 2020-05-22 | 42 | P23490 | Espacenet |
| WO 2020099829 A1 | 2020-05-22 | 42 | P23490 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants868
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LORICRIN papers | Newest fiscal year |
|---|---|---|---|
| R01AR041836 | Function of Desmoglein 1/Pemphigus Foliaceus Antigen | 8 | 2025 |
| P30AR075043 | University of Michigan Skin Biology and Diseases Resource-based Center | 7 | 2025 |
| R01AR066530 | Regulators of epidermal growth and differentiation | 7 | 2025 |
| P30AR075047 | Skin Biology Resource-Based Center at UCI | 6 | 2025 |
| P30AR075049 | Northwestern University Skin Biology and Diseases Resource-based Center | 6 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 6 | 2025 |
| R01AR045192 | REGULATORS OF EPIDERMAL GENE EXPRESSION | 6 | 2025 |
| T32CA009302 | Leveraging innovative technologies in basic and clinical cancer research | 6 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 6 | 2025 |
| I01BX004293 | CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer | 5 | 2025 |
1 to 10 of 868Source NIH's project files
See all 868 nih grantsPapers2,126
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Anoectochilus roxburghii extract alleviates inflammation and restores skin barrier function in vitro and in vivo. | Fitoterapia | 2026 | 42800590 | PubTator, text mining | PubMed |
| ML281 Does Not Function as an STK33 Inhibitor but Modulates Proliferation and Differentiation of Keratinocytes Derived from Hypertrophic Scars. | Int J Mol Sci | 2026 | 42794700 | PubTator, text mining | PubMed |
| Lipoic acid synthase modulates psoriasis-like keratinocyte dysfunction in association with oxidative stress, ferroptosis-associated remodeling, and STAT3/NF-κB activation. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42776206 | PubTator, text mining | PubMed |
| Characterization of epidermal and dermal remodeling following skin injury by sulfur mustard in Göttingen minipigs. | Cutan Ocul Toxicol | 2026 | 42632083 | PubTator, text mining | PubMed |
| Comparative analysis of candidate gene expression in Asian atopic dermatitis and psoriasis: identification of shared and distinct molecular features. | Front Med (Lausanne) | 2026 | 42614128 | PubTator, text mining | PubMed |
| Multi-omics integration of gut-skin axis in probiotic-treated dermatological conditions. | Front Cell Infect Microbiol | 2026 | 42516436 | PubTator, text mining | PubMed |
| Translational Assessment of a Cell-Penetrating Peptide Topical Formulation for Repairing Barrier Dysfunction in Human Skin. | Int J Mol Sci | 2026 | 42511700 | PubTator, text mining | PubMed |
| Jaungo-based herbal complex regulates psoriasis-associated macrophage-keratinocyte inflammatory axis. | Front Pharmacol | 2026 | 42482777 | PubTator, text mining | PubMed |
| Interface-engineered supramolecular collagen peptide nanocapsules for barrier repair and matrix remodeling: From molecular assembly to clinical translation. | J Control Release | 2026 | 42480655 | PubTator, text mining | PubMed |
| The LCE3D/TGF-β1 Axis in atopic dermatitis: Expression profiling, clinical significance, and mechanistic insights into epithelial-immune crosstalk. | Clin Immunol | 2026 | 42435926 | PubTator, text mining | PubMed |
1 to 10 of 2,126
See all 2,126 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4014
GET https://conductscience.org/api/genes/v1/4014/patents