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Library / Genes

LPA: lipoprotein(a)

1 protein, 38 patents, 2 drugs, 6 trials, 3,840 NIH grants and 13,816 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLPAHGNC
Namelipoprotein(a)HGNC
NCBI Gene ID4018NCBI Gene
HGNC IDHGNC:6667HGNC
EnsemblENSG00000198670NCBI Gene
AliasesAK38, APOA, LP, Lp(a)NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08519Apolipoprotein(a)2,04016Ensembl, GeneID, HGNCUniProt

Patents 38

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026511099 A2026-04-102P08519Espacenet
EP 4684017 A22026-01-282P08519Espacenet
JP 2026004568 A2026-01-1451886P08519Espacenet
JP 2026004568 A2026-01-1451887P08519Espacenet
KR 1020250163949 A2025-11-212P08519Espacenet
EP 4650780 A22025-11-195368P08519Espacenet
EP 4640849 A22025-10-29759P08519Espacenet
EP 4641201 A22025-10-294958P08519Espacenet
JP 2025147176 A2025-10-067967P08519Espacenet
WO 2025199298 A12025-09-251P08519Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
OLPASIRANCHEMBL4650413LPA mRNA rnai inhibitorRNAI INHIBITORChEMBL
PELACARSENCHEMBL4298202LPA mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07517263PELACARSENPHASE3ClinicalTrials.gov
NCT05900141PELACARSENPHASE3ClinicalTrials.gov
NCT05305664PELACARSENPHASE3ClinicalTrials.gov
NCT04993664PELACARSENClinicalTrials.gov
NCT03070782PELACARSENPHASE22020-10-30ClinicalTrials.gov
NCT02414594PELACARSENPHASE1ClinicalTrials.gov

NIH grants 3840

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK017047Diabetes Research Center172,025NIH's project files
R01HL142711Whole genome sequences in ethnically diverse individuals to comprehensively characterize the genetic mechanisms of dyslipidemias172,025NIH's project files
P30DK063491Diabetes Research Center (DRC)152,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award152,025NIH's project files
P30CA016672Cancer Center Support Grant132,025NIH's project files
T32HL079891UCSD Integrated Cardiovascular Epidemiology Fellowship122,025NIH's project files
U01HG006379EHR-based Genomic Discovery and Implementation [Funded Extension]112,025NIH's project files
UL1TR001860UC Davis Clinical and Translational Science Center112,025NIH's project files
UL1TR002243Vanderbilt Institute for Clinical and Translational Research (VICTR)112,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal102,025NIH's project files

Papers 13816

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819403PubTator, text miningPubMed
42818569PubTator, text miningPubMed
42818356PubTator, text miningPubMed
42814997PubTator, text miningPubMed
42814261PubTator, text miningPubMed
42814209PubTator, text miningPubMed
42811515PubTator, text miningPubMed
42810872PubTator, text miningPubMed
42810473PubTator, text miningPubMed
42809906PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license