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LRP1: LDL receptor related protein 1

1 protein, 75 patents, 1 drug, 7 trials, 5,850 NIH grants and 9,917 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLRP1HGNC
NameLDL receptor related protein 1HGNC
NCBI Gene ID4035NCBI Gene
HGNC IDHGNC:6692HGNC
EnsemblENSG00000123384NCBI Gene
AliasesA2MR, APOER, APR, CD91, DDH3, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q07954Prolow-density lipoprotein receptor-related protein 14,5447Ensembl, GeneID, HGNCUniProt

Patents 75

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4752548 A12026-06-0313Q07954Espacenet
JP 2026062949 A2026-04-1010Q07954Espacenet
JP 2026004568 A2026-01-1451914Q07954Espacenet
US 12502368 B22025-12-2310Q07954Espacenet
WO 2025259600 A22025-12-186Q07954Espacenet
EP 4650780 A22025-11-191080Q07954Espacenet
EP 4641201 A22025-10-29759Q07954Espacenet
EP 4641202 A22025-10-2941Q07954Espacenet
EP 4641203 A22025-10-2933Q07954Espacenet
JP 2025147176 A2025-10-068004Q07954Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ANG1005CHEMBL1089636Prolow-density lipoprotein receptor-related protein 1 binding agentBINDING AGENTChEMBL

Trials 7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03613181ANG1005PHASE3ClinicalTrials.gov
NCT02755987ANG1005ClinicalTrials.gov
NCT02048059ANG1005PHASE2ClinicalTrials.gov
NCT01967810ANG1005PHASE2ClinicalTrials.gov
NCT01497665ANG1005PHASE22015-12-14ClinicalTrials.gov
NCT01480583ANG1005PHASE2ClinicalTrials.gov
NCT00539344ANG1005PHASE1ClinicalTrials.gov

NIH grants 5850

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant232,025NIH's project files
P30CA008748Cancer Center Support Grant182,025NIH's project files
R01HL055374Unraveling the role of tPA in the neurovascular unit152,025NIH's project files
P20GM103424Louisiana Biomedical Research Network142,025NIH's project files
T32HL007698Interdisciplinary Training Program in Cardiovascular Disease122,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal112,025NIH's project files
P30AG062421Massachusetts Alzheimer's Disease Research Center (MADRC)102,025NIH's project files
P30CA006973Regional Oncology Research Center102,025NIH's project files
R01HL136395Regulation of Inflammation by the Fibrinolytic System102,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award102,025NIH's project files

Papers 9917

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42811903PubTator, text miningPubMed
42800242PubTator, text miningPubMed
42789062PubTator, text miningPubMed
42764574PubTator, text miningPubMed
42748964PubTator, text miningPubMed
42740496PubTator, text miningPubMed
42687504PubTator, text miningPubMed
42671505PubTator, text miningPubMed
42670766PubTator, text miningPubMed
42665834PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license