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Gene · 4036

LRP2: LDL receptor related protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LRP2: LDL receptor related protein 2. Genes, record 4036. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4036

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Gene

Symbol
LRP2
HGNC
Name
LDL receptor related protein 2
HGNC
NCBI Gene ID
4036
NCBI Gene
HGNC ID
HGNC:6694
HGNC
Ensembl
ENSG00000081479
NCBI Gene
Aliases
DBS, GP330, LRP-2, gp330
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P98164Low-density lipoprotein receptor-related protein 24,6554Ensembl, GeneID, HGNC

Source UniProt

Patents67

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451917P98164Espacenet
EP 4650780 A22025-11-1919554P98164Espacenet
EP 4640849 A22025-10-294048P98164Espacenet
EP 4641201 A22025-10-2925220P98164Espacenet
JP 2025147176 A2025-10-068016P98164Espacenet
JP 2025529142 A2025-09-042437P98164Espacenet
JP 2025529142 A2025-09-046924P98164Espacenet
US 12371689 B22025-07-292437P98164Espacenet
US 12371689 B22025-07-296924P98164Espacenet
JP 2025519096 A2025-06-244048P98164Espacenet

1 to 10 of 67

See all 67 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,425

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLRP2 papersNewest fiscal year
ZIACP010195Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study72025
P30DK063491Diabetes Research Center (DRC)62025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal62025
UL1TR001863Yale Clinical and Translational Science Award62025
P01HL116263HDL Function in Human Disease52025
P30CA016672Cancer Center Support Grant52025
P30DK058404Molecular and Cellular Basis for Digestive Diseases52025
R01DK039773Mechanisms of Ischemic Kidney Injury and Repair52025
R01DK072381Kidney Injury Molecule-1 in Epithelial Repair52025
R01DK067299Novel Roles and Mechanisms of Proximal Tubule Mitochondrial Angiotensin II and Sirtuin 3 in Hypertension42025

1 to 10 of 2,425Source NIH's project files

See all 2,425 nih grants

Papers3,623

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A new beating heart model of cardiopulmonary bypass-induced acute kidney injury demonstrates heme protein toxicity and ferroptosis.Am J Nephrol202642809521PubTator, text miningPubMed
SCTR-Expressing Astrocyte-Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac-Foxc2 Epigenetic Axis in an AMPK-Dependent Manner.Adv Sci (Weinh)202642801528PubTator, text miningPubMed
LRP2: A proteogenomics pipeline for long-read informed protein isoform analysis and discovery.bioRxiv202642779594PubTator, text miningPubMed
Kidney organoids as a platform to study plasminogen-induced injury and uPA-based therapies.Stem Cells Transl Med202642768826PubTator, text miningPubMed
Computational prioritization of megalin-aminoglycoside recognition and gentamicin-associated cellular stress responses.Arch Biochem Biophys202642762957PubTator, text miningPubMed
Molecular characterization of normal and physiologically suppressed human parathyroid glands at single-cell resolution.J Endocr Soc202642761548PubTator, text miningPubMed
Megalin: from structure to function.Nat Rev Nephrol202642760389PubTator, text miningPubMed
LINC00460 drives clear cell renal cell carcinoma progression via complement/coagulation and p53 pathways: a potential therapeutic target.Am J Transl Res202642630874PubTator, text miningPubMed
COPI Coatomer Regulates Several Steps of HDL Metabolism.Arterioscler Thromb Vasc Biol202642592650PubTator, text miningPubMed
Unveiling differential gene expression and pathways in clear cell renal cell carcinoma with sarcomatoid transformation.PeerJ202642569572PubTator, text miningPubMed

1 to 10 of 3,623

See all 3,623 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4036

GET https://conductscience.org/api/genes/v1/4036/patents?page=2