Gene · 4038
LRP4: LDL receptor related protein 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LRP4: LDL receptor related protein 4. Genes, record 4038. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4038
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O75096 | Low-density lipoprotein receptor-related protein 4 | 1,905 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 51922 | O75096 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10065 | O75096 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10349 | O75096 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8018 | O75096 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2439 | O75096 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6925 | O75096 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2439 | O75096 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6925 | O75096 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10349 | O75096 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10065 | O75096 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants817
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LRP4 papers | Newest fiscal year |
|---|---|---|---|
| R01AI114780 | Mechanisms of autoimmunity in myasthenia gravis | 13 | 2025 |
| U54NS115054 | Rare Disease Network for Myasthenia Gravis | 12 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 8 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 6 | 2025 |
| R01AR041398 | Novel Molecular Biomarkers of Bone Microarchitecture | 6 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 3 | 2025 |
| R01NS055028 | Patterning and Formation of the Neuromuscular Junction | 3 | 2025 |
| I01BX001478 | Harnessing the anabolic potential of Wnt signaling to improve bone health | 2 | 2025 |
1 to 10 of 817Source NIH's project files
See all 817 nih grantsPapers1,660
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Crk/Crk-L-mediated Rapgef1 recruitment couples MuSK signaling to AChR anchoring at the neuromuscular junction. | Cell Chem Biol | 2026 | 42772281 | PubTator, text mining | PubMed |
| Exploring causal associations between the plasma proteome and bone mineral density: a Mendelian randomization study. | Endocr Connect | 2026 | 42765911 | PubTator, text mining | PubMed |
| Digital assessment in myasthenia gravis: evidence, validation, and a proposed framework for autoimmune heterogeneity, remote monitoring, and clinical endpoints. | Front Immunol | 2026 | 42756700 | PubTator, text mining | PubMed |
| A case report of sequential efgartigimod and rituximab treatment for tSNMG. | Front Immunol | 2026 | 42755762 | PubTator, text mining | PubMed |
| Case Report: Probable toripalimab-associated ocular myasthenia gravis-like presentation after chemoimmunotherapy. | Front Neurol | 2026 | 42741200 | PubTator, text mining | PubMed |
| TUBA4A Pathogenic Variant Manifesting With Adulthood-Onset Genetic Myasthenic Syndrome, Myopathy, and Infertility. | Eur J Neurol | 2026 | 42725680 | PubTator, text mining | PubMed |
| MuSK myasthenia gravis: from antigen-antibody to clinical translation. | Front Immunol | 2026 | 42582756 | PubTator, text mining | PubMed |
| New-Onset Myasthenia Gravis Associated with SARS-CoV-2 Infection: A Systematic Review. | Life (Basel) | 2026 | 42514170 | PubTator, text mining | PubMed |
| LRP4-Related Congenital Myasthenic Syndrome: Clinical, Pathophysiological, and Therapeutic Aspects. | Muscles | 2026 | 42496377 | PubTator, text mining | PubMed |
| E3 ubiquitin-ligase Hakai regulates LRP4 stability and Wnt/β-catenin signalling in colorectal cancer cells. | iScience | 2026 | 42472112 | PubTator, text mining | PubMed |
1 to 10 of 1,660
See all 1,660 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4038
GET https://conductscience.org/api/genes/v1/4038/patents?page=2