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Gene · 4038

LRP4: LDL receptor related protein 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LRP4: LDL receptor related protein 4. Genes, record 4038. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4038

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Gene

Symbol
LRP4
HGNC
Name
LDL receptor related protein 4
HGNC
NCBI Gene ID
4038
NCBI Gene
HGNC ID
HGNC:6696
HGNC
Ensembl
ENSG00000134569
NCBI Gene
Aliases
CLSS, CMS17, LRP-4, LRP10, MEGF7, SOST2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75096Low-density lipoprotein receptor-related protein 41,9051Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451922O75096Espacenet
EP 4650780 A22025-11-1910065O75096Espacenet
EP 4641201 A22025-10-2910349O75096Espacenet
JP 2025147176 A2025-10-068018O75096Espacenet
JP 2025529142 A2025-09-042439O75096Espacenet
JP 2025529142 A2025-09-046925O75096Espacenet
US 12371689 B22025-07-292439O75096Espacenet
US 12371689 B22025-07-296925O75096Espacenet
JP 2025517969 A2025-06-1210349O75096Espacenet
JP 2025517970 A2025-06-1210065O75096Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants817

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLRP4 papersNewest fiscal year
R01AI114780Mechanisms of autoimmunity in myasthenia gravis132025
U54NS115054Rare Disease Network for Myasthenia Gravis122025
UL1TR001863Yale Clinical and Translational Science Award82025
P30CA016087Cancer Center Support Grant62025
R01AR041398Novel Molecular Biomarkers of Bone Microarchitecture62025
P30DK063491Diabetes Research Center (DRC)52025
P30CA016672Cancer Center Support Grant32025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal32025
R01NS055028Patterning and Formation of the Neuromuscular Junction32025
I01BX001478Harnessing the anabolic potential of Wnt signaling to improve bone health22025

1 to 10 of 817Source NIH's project files

See all 817 nih grants

Papers1,660

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Crk/Crk-L-mediated Rapgef1 recruitment couples MuSK signaling to AChR anchoring at the neuromuscular junction.Cell Chem Biol202642772281PubTator, text miningPubMed
Exploring causal associations between the plasma proteome and bone mineral density: a Mendelian randomization study.Endocr Connect202642765911PubTator, text miningPubMed
Digital assessment in myasthenia gravis: evidence, validation, and a proposed framework for autoimmune heterogeneity, remote monitoring, and clinical endpoints.Front Immunol202642756700PubTator, text miningPubMed
A case report of sequential efgartigimod and rituximab treatment for tSNMG.Front Immunol202642755762PubTator, text miningPubMed
Case Report: Probable toripalimab-associated ocular myasthenia gravis-like presentation after chemoimmunotherapy.Front Neurol202642741200PubTator, text miningPubMed
TUBA4A Pathogenic Variant Manifesting With Adulthood-Onset Genetic Myasthenic Syndrome, Myopathy, and Infertility.Eur J Neurol202642725680PubTator, text miningPubMed
MuSK myasthenia gravis: from antigen-antibody to clinical translation.Front Immunol202642582756PubTator, text miningPubMed
New-Onset Myasthenia Gravis Associated with SARS-CoV-2 Infection: A Systematic Review.Life (Basel)202642514170PubTator, text miningPubMed
LRP4-Related Congenital Myasthenic Syndrome: Clinical, Pathophysiological, and Therapeutic Aspects.Muscles202642496377PubTator, text miningPubMed
E3 ubiquitin-ligase Hakai regulates LRP4 stability and Wnt/β-catenin signalling in colorectal cancer cells.iScience202642472112PubTator, text miningPubMed

1 to 10 of 1,660

See all 1,660 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4038

GET https://conductscience.org/api/genes/v1/4038/patents?page=2