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LRP6: LDL receptor related protein 6

1 protein, 62 patents, 0 drugs, 0 trials, 2,782 NIH grants and 4,932 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLRP6HGNC
NameLDL receptor related protein 6HGNC
NCBI Gene ID4040NCBI Gene
HGNC IDHGNC:6698HGNC
EnsemblENSG00000070018NCBI Gene
AliasesADCAD2, EVR8, OPTA4, STHAG7NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O75581Low-density lipoprotein receptor-related protein 61,61330Ensembl, GeneID, HGNCUniProt

Patents 62

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120541 A2026-07-2279O75581Espacenet
JP 2026082857 A2026-05-1979O75581Espacenet
JP 2026508054 A2026-03-1031O75581Espacenet
JP 2026004568 A2026-01-1451924O75581Espacenet
EP 4650780 A22025-11-191875O75581Espacenet
EP 4641201 A22025-10-291461O75581Espacenet
EP 4641202 A22025-10-2991O75581Espacenet
EP 4641203 A22025-10-2959O75581Espacenet
JP 2025529142 A2025-09-042441O75581Espacenet
EP 4608873 A12025-09-0331O75581Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2782

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant252,025NIH's project files
R01EY019309A new pathogenic mechanism for diabetic retinopathy202,025NIH's project files
P30CA008748Cancer Center Support Grant122,025NIH's project files
R01AR053237Lrp5 and Lrp6 signaling in bone mechanotransduction and metabolism112,025NIH's project files
P30CA016042Cancer Center Support Grant92,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases92,025NIH's project files
R35GM122516Maximizing Investigators' Research Award (R35 - Clinical Trial Optional)82,025NIH's project files
P30CA013148Comprehensive Cancer Center Support Grant72,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award72,025NIH's project files
I01BX001478Harnessing the anabolic potential of Wnt signaling to improve bone health62,025NIH's project files

Papers 4932

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42807979PubTator, text miningPubMed
42749233PubTator, text miningPubMed
42739253PubTator, text miningPubMed
42723884PubTator, text miningPubMed
42681341PubTator, text miningPubMed
42677203PubTator, text miningPubMed
42637927PubTator, text miningPubMed
42594142PubTator, text miningPubMed
42577862PubTator, text miningPubMed
42576420PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license