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Gene · 4047

LSS: lanosterol synthase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LSS: lanosterol synthase. Genes, record 4047. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4047

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Gene

Symbol
LSS
HGNC
Name
lanosterol synthase
HGNC
NCBI Gene ID
4047
NCBI Gene
HGNC ID
HGNC:6708
HGNC
Ensembl
ENSG00000160285
NCBI Gene
Aliases
APMR4, CTRCT44, HYPT14, OSC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48449Lanosterol synthase7322Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451135P48449Espacenet
JP 2026004568 A2026-01-1451136P48449Espacenet
EP 4650780 A22025-11-197287P48449Espacenet
EP 4641201 A22025-10-297239P48449Espacenet
EP 4641202 A22025-10-295251P48449Espacenet
JP 2025517969 A2025-06-127239P48449Espacenet
JP 2025517970 A2025-06-127287P48449Espacenet
KR 1020250017231 A2025-02-045251P48449Espacenet
US 11446398 B22022-09-2045016P48449Espacenet
US 11446398 B22022-09-2045017P48449Espacenet

1 to 10 of 50

See all 50 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants670

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLSS papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P30CA046934University of Colorado Cancer Center Support Grant42025
P30ES010126UNC Center for Environmental Health and Susceptibility42025
P30CA016359Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
P30CA047904Cancer Center Support Grant22025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center22025
P30CA082709Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant22025
P30CA086862Cancer Center Support Grant22025

1 to 10 of 670Source NIH's project files

See all 670 nih grants

Papers1,367

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Gypenosides Damulin A and Damulin B Inhibit Hepatocellular Carcinoma by Regulating Cholesterol Synthesis.Drug Dev Res202642750477PubTator, text miningPubMed
Identification of potential key genes involved in iron deficiency for sepsis: A retrospective cohort and transcriptomic study.Medicine (Baltimore)202642736720PubTator, text miningPubMed
Benzophenone Derivatives as a New Class of Anti-Infectives Against Acanthamoeba spp.Arch Pharm (Weinheim)202642622452PubTator, text miningPubMed
Corrigendum to "The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway" [J. Pharm. Anal. 13 (2023) 39-54].J Pharm Anal202642620679PubTator, text miningPubMed
Piezo1 Activation by Shear Stress Induces Corneal Epithelial Homeostasis Disruption.Invest Ophthalmol Vis Sci202642439605PubTator, text miningPubMed
Overexpression of the ATP-Citrate Lyase Gene Enhances Ganoderic Acid Biosynthesis in Ganoderma lingzhi.Mol Biotechnol202642350876PubTator, text miningPubMed
Prediction of Oswestry Disability Index and Numeric Rating Scale scores after lumbar spine surgery: machine learning model development and fairness assessment.BMJ Open202642128507PubTator, text miningPubMed
Single-site amino acid residue mutation reshapes the characteristics of double bond positions for protostadienol-type triterpenols.Phytochemistry202642106134PubTator, text miningPubMed
Interaction of bi-nuclear gallium(III) complexes with human serum albumin and impact on potency towards osteosarcoma stem cells.Dalton Trans202642023658PubTator, text miningPubMed
Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases.Metabolites202641893338PubTator, text miningPubMed

1 to 10 of 1,367

See all 1,367 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4047

GET https://conductscience.org/api/genes/v1/4047/patents?page=2