Gene · 4048
LTA4H: leukotriene A4 hydrolase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LTA4H: leukotriene A4 hydrolase. Genes, record 4048. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4048
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P09960 | Leukotriene A-4 hydrolase | 611 | 77 | Ensembl, GeneID, HGNC |
Source UniProt
Patents25
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 51640 | P09960 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 709 | P09960 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 709 | P09960 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 46547 | P09960 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 149518 | P09960 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 6395 | P09960 | Espacenet |
| US 10918740 B2 | 2021-02-16 | 4657 | P09960 | Espacenet |
| US 10869935 B2 | 2020-12-22 | 4657 | P09960 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 1352 | P09960 | Espacenet |
| US 10293058 B2 | 2019-05-21 | 4657 | P09960 | Espacenet |
1 to 10 of 25
See all 25 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| ACEBILUSTAT | CHEMBL4297604 | Leukotriene A4 hydrolase inhibitor | INHIBITOR |
Source ChEMBL
Trials6
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05203835 | ACEBILUSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT04662086 | ACEBILUSTAT | PHASE2 | 2023-05-30 | ClinicalTrials.gov |
| NCT04662060 | ACEBILUSTAT | PHASE2 | 2023-06-13 | ClinicalTrials.gov |
| NCT02443688 | ACEBILUSTAT | PHASE2 | 2019-07-25 | ClinicalTrials.gov |
| NCT02385760 | ACEBILUSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT01944735 | ACEBILUSTAT | PHASE1 | ClinicalTrials.gov |
NIH grants1,171
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LTA4H papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30ES005022 | Rutgers Center for Environmental Exposure and Disease (CEED) | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA072720 | Cancer Center Support Grant | 3 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 3 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 3 | 2025 |
| R01AI054503 | Host responses to Mycobacterium infection in Zebrafish | 3 | 2025 |
| R01ES004738 | Activated Macrophages and Ozone Toxicity | 3 | 2025 |
| T32HL007427 | SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES | 3 | 2025 |
| T32HL105346 | Training Program in Lung Biology and Translational Medicine | 3 | 2025 |
1 to 10 of 1,171Source NIH's project files
See all 1,171 nih grantsPapers1,725
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Expression and clinical significance of LTA4H in esophageal squamous cell carcinoma. | J Toxicol Environ Health A | 2027 | 42403040 | PubTator, text mining | PubMed |
| Blood Eosinophil Subtype-Specific Protein Gene Expression and Eosinophil-Derived Serum Mediators in Allergic Asthma Patients After Bronchial Challenge with Dermatophagoides pteronyssinus. | Cells | 2026 | 42738872 | PubTator, text mining | PubMed |
| Holding the granuloma together: Fibroblasts contain mycobacterial infection. | Cell Host Microbe | 2026 | 42716002 | PubTator, text mining | PubMed |
| SIV/HIV Induces Arachidonic Acid-Mediated Inflammation in the Heart by a Pannexin-1 Mechanism. | Am J Pathol | 2026 | 42665161 | PubTator, text mining | PubMed |
| Host eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial containment. | Cell Host Microbe | 2026 | 42641606 | PubTator, text mining | PubMed |
| Bestatin inhibits the development of cutaneous melanoma by inhibiting the expression of LTA4H. | Front Immunol | 2026 | 42582114 | PubTator, text mining | PubMed |
| In vivo CRISPR screening identifies LTA4H as a target for potentiating immunotherapy efficacy via the LTB4-neutrophil axis. | Int Immunopharmacol | 2026 | 42537346 | PubTator, text mining | PubMed |
| MALDI-MSI Profiling of Effusion Cytology Cell Blocks Distinguishes High-Grade Serous Ovarian Carcinoma from Benign Effusions. | Cancers (Basel) | 2026 | 42512330 | PubTator, text mining | PubMed |
| Potential evaluation of SULT1A3 as an early diagnostic marker for nasopharyngeal carcinoma: a study based on serum proteomics screening and ELISA validation. | BMC Cancer | 2026 | 42365246 | PubTator, text mining | PubMed |
| Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts. | Cell Rep | 2026 | 42276069 | PubTator, text mining | PubMed |
1 to 10 of 1,725
See all 1,725 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4048
GET https://conductscience.org/api/genes/v1/4048/patents?page=2