ConductScience.org, home

Gene · 4048

LTA4H: leukotriene A4 hydrolase

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. LTA4H: leukotriene A4 hydrolase. Genes, record 4048. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4048

On this page

Gene

Symbol
LTA4H
HGNC
Name
leukotriene A4 hydrolase
HGNC
NCBI Gene ID
4048
NCBI Gene
HGNC ID
HGNC:6710
HGNC
Ensembl
ENSG00000111144
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09960Leukotriene A-4 hydrolase61177Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451640P09960Espacenet
EP 4650780 A22025-11-19709P09960Espacenet
JP 2025517970 A2025-06-12709P09960Espacenet
US 11446398 B22022-09-2046547P09960Espacenet
JP 2022524081 A2022-04-27149518P09960Espacenet
US 11078247 B22021-08-036395P09960Espacenet
US 10918740 B22021-02-164657P09960Espacenet
US 10869935 B22020-12-224657P09960Espacenet
WO 2020043864 A12020-03-051352P09960Espacenet
US 10293058 B22019-05-214657P09960Espacenet

1 to 10 of 25

See all 25 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ACEBILUSTATCHEMBL4297604Leukotriene A4 hydrolase inhibitorINHIBITOR

Source ChEMBL

Trials6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05203835ACEBILUSTATPHASE2ClinicalTrials.gov
NCT04662086ACEBILUSTATPHASE22023-05-30ClinicalTrials.gov
NCT04662060ACEBILUSTATPHASE22023-06-13ClinicalTrials.gov
NCT02443688ACEBILUSTATPHASE22019-07-25ClinicalTrials.gov
NCT02385760ACEBILUSTATPHASE2ClinicalTrials.gov
NCT01944735ACEBILUSTATPHASE1ClinicalTrials.gov

NIH grants1,171

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLTA4H papersNewest fiscal year
P30CA016672Cancer Center Support Grant42025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)42025
P30CA008748Cancer Center Support Grant32025
P30CA072720Cancer Center Support Grant32025
P30CA091842Cancer Center Support Grant32025
P30ES010126UNC Center for Environmental Health and Susceptibility32025
R01AI054503Host responses to Mycobacterium infection in Zebrafish32025
R01ES004738Activated Macrophages and Ozone Toxicity32025
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES32025
T32HL105346Training Program in Lung Biology and Translational Medicine32025

1 to 10 of 1,171Source NIH's project files

See all 1,171 nih grants

Papers1,725

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Expression and clinical significance of LTA4H in esophageal squamous cell carcinoma.J Toxicol Environ Health A202742403040PubTator, text miningPubMed
Blood Eosinophil Subtype-Specific Protein Gene Expression and Eosinophil-Derived Serum Mediators in Allergic Asthma Patients After Bronchial Challenge with Dermatophagoides pteronyssinus.Cells202642738872PubTator, text miningPubMed
Holding the granuloma together: Fibroblasts contain mycobacterial infection.Cell Host Microbe202642716002PubTator, text miningPubMed
SIV/HIV Induces Arachidonic Acid-Mediated Inflammation in the Heart by a Pannexin-1 Mechanism.Am J Pathol202642665161PubTator, text miningPubMed
Host eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial containment.Cell Host Microbe202642641606PubTator, text miningPubMed
Bestatin inhibits the development of cutaneous melanoma by inhibiting the expression of LTA4H.Front Immunol202642582114PubTator, text miningPubMed
In vivo CRISPR screening identifies LTA4H as a target for potentiating immunotherapy efficacy via the LTB4-neutrophil axis.Int Immunopharmacol202642537346PubTator, text miningPubMed
MALDI-MSI Profiling of Effusion Cytology Cell Blocks Distinguishes High-Grade Serous Ovarian Carcinoma from Benign Effusions.Cancers (Basel)202642512330PubTator, text miningPubMed
Potential evaluation of SULT1A3 as an early diagnostic marker for nasopharyngeal carcinoma: a study based on serum proteomics screening and ELISA validation.BMC Cancer202642365246PubTator, text miningPubMed
Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts.Cell Rep202642276069PubTator, text miningPubMed

1 to 10 of 1,725

See all 1,725 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4048

GET https://conductscience.org/api/genes/v1/4048/patents?page=2