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LTA: lymphotoxin alpha

1 protein, 345 patents, 2 drugs, 10 trials, 5,384 NIH grants and 10,652 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLTAHGNC
Namelymphotoxin alphaHGNC
NCBI Gene ID4049NCBI Gene
HGNC IDHGNC:6709HGNC
EnsemblENSG00000226979NCBI Gene
AliasesLT, TNFB, TNFSF1, TNLG1ENCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01374Lymphotoxin-alpha2053Ensembl, GeneID, HGNCUniProt

Patents 345

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086743 A2026-05-26167P01374Espacenet
EP 4705273 A22026-03-11326P01374Espacenet
WO 2026019692 A22026-01-229P01374Espacenet
JP 2026004568 A2026-01-1452036P01374Espacenet
JP 2026004568 A2026-01-1452037P01374Espacenet
JP 2026004568 A2026-01-1452038P01374Espacenet
JP 2026004568 A2026-01-1452040P01374Espacenet
JP 2026004568 A2026-01-1452044P01374Espacenet
JP 2026004568 A2026-01-1452045P01374Espacenet
JP 2026500896 A2026-01-0922P01374Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BAMINERCEPTCHEMBL1742988Heterotrimeric lymphotoxin LTa1b2 inhibitorINHIBITORChEMBL
PATECLIZUMABCHEMBL1743056TNF-beta inhibitorINHIBITORChEMBL

Trials 10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01552681BAMINERCEPTPHASE22016-03-23ClinicalTrials.gov
NCT01225393PATECLIZUMABPHASE2ClinicalTrials.gov
NCT01181089BAMINERCEPTPHASE1/PHASE2ClinicalTrials.gov
NCT01164384BAMINERCEPTPHASE1ClinicalTrials.gov
NCT00888745PATECLIZUMABPHASE1ClinicalTrials.gov
NCT00664716BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00664573BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00523328BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00458861BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00292422BAMINERCEPTPHASE2ClinicalTrials.gov

NIH grants 5384

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant262,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition142,025NIH's project files
P30CA008748Cancer Center Support Grant122,025NIH's project files
P30CA047904Cancer Center Support Grant112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award102,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant92,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success92,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant82,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro82,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research72,025NIH's project files

Papers 10652

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826314PubTator, text miningPubMed
42803886PubTator, text miningPubMed
42772652PubTator, text miningPubMed
42752598PubTator, text miningPubMed
42737480PubTator, text miningPubMed
42726432PubTator, text miningPubMed
42703724PubTator, text miningPubMed
42700226PubTator, text miningPubMed
42682632PubTator, text miningPubMed
42664610PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license