Gene · 4050
LTB: lymphotoxin beta
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LTB: lymphotoxin beta. Genes, record 4050. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4050
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q06643 | Lymphotoxin-beta | 244 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents262
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026086743 A | 2026-05-26 | 163 | Q06643 | Espacenet |
| EP 4705273 A2 | 2026-03-11 | 327 | Q06643 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52052 | Q06643 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52053 | Q06643 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52054 | Q06643 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52055 | Q06643 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52056 | Q06643 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52057 | Q06643 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52059 | Q06643 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52060 | Q06643 | Espacenet |
1 to 10 of 262
See all 262 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| BAMINERCEPT | CHEMBL1742988 | Heterotrimeric lymphotoxin LTa1b2 inhibitor | INHIBITOR |
Source ChEMBL
Trials8
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT01552681 | BAMINERCEPT | PHASE2 | 2016-03-23 | ClinicalTrials.gov |
| NCT01181089 | BAMINERCEPT | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT01164384 | BAMINERCEPT | PHASE1 | ClinicalTrials.gov | |
| NCT00664716 | BAMINERCEPT | PHASE2 | ClinicalTrials.gov | |
| NCT00664573 | BAMINERCEPT | PHASE2 | ClinicalTrials.gov | |
| NCT00523328 | BAMINERCEPT | PHASE2 | ClinicalTrials.gov | |
| NCT00458861 | BAMINERCEPT | PHASE2 | ClinicalTrials.gov | |
| NCT00292422 | BAMINERCEPT | PHASE2 | ClinicalTrials.gov |
NIH grants1,907
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LTB papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 7 | 2025 |
| P30DK052574 | Host-environment interactions in the pathophysiology of digestive disease | 6 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 5 | 2025 |
| P01CA155258 | Integrative Oncogenomics of Multiple Myeloma | 4 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 4 | 2025 |
| U19AI118626 | Respiratory pathogen-specific T cell signatures following vaccination, natural infection, and treatment | 4 | 2025 |
1 to 10 of 1,907Source NIH's project files
See all 1,907 nih grantsPapers2,481
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Liver-eye axis in metabolic syndrome: integrated evidence from mendelian randomization, single-cell sequencing, and clinical sample validation. | Front Endocrinol (Lausanne) | 2026 | 42780180 | PubTator, text mining | PubMed |
| Youthful systemic factors restore aged liver regeneration through LTβ-driven hepatocyte reprogramming. | J Hepatol | 2026 | 42772698 | PubTator, text mining | PubMed |
| Stratifying lung adenocarcinoma: a novel prognostic model based on mitochondrial outer membrane permeabilization activity. | 3 Biotech | 2026 | 42745950 | PubTator, text mining | PubMed |
| Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes. | J Clin Invest | 2026 | 42741944 | PubTator, text mining | PubMed |
| Identification of NETs and inflammation-related prognostic genes in breast cancer and PCR experimental validation. | Front Genet | 2026 | 42695096 | PubTator, text mining | PubMed |
| Single-cell transcriptomic profile unveils distinct immune ecosystems in alcohol- and nonalcohol-associated hepatocellular carcinoma. | Front Immunol | 2026 | 42682632 | PubTator, text mining | PubMed |
| Combination antagonism of TNF superfamily signaling for T cell immunosuppression. | Front Immunol | 2026 | 42564165 | PubTator, text mining | PubMed |
| Exploring LTB-mediated T cell differentiation as a prognostic marker in triple-negative breast cancer. | Breast Cancer Res | 2026 | 42381077 | PubTator, text mining | PubMed |
| Single-cell transcriptomic analysis identifies a tumor-enriched GIMAP7⁺ CD4⁺ naïve T cell population with a unique immunoregulatory state in lung adenocarcinoma. | Funct Integr Genomics | 2026 | 42371181 | PubTator, text mining | PubMed |
| Decoding isonicotinylation-associated patterns in neutrophil chronic obstructive pulmonary disease: evidence from integrative bioinformatic-driven multi-omics and in vitro validation. | Front Physiol | 2026 | 42344274 | PubTator, text mining | PubMed |
1 to 10 of 2,481
See all 2,481 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4050
GET https://conductscience.org/api/genes/v1/4050/patents?page=2