ConductScience.org, home

Gene · 4050

LTB: lymphotoxin beta

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. LTB: lymphotoxin beta. Genes, record 4050. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4050

On this page

Gene

Symbol
LTB
HGNC
Name
lymphotoxin beta
HGNC
NCBI Gene ID
4050
NCBI Gene
HGNC ID
HGNC:6711
HGNC
Ensembl
ENSG00000227507
NCBI Gene
Aliases
TNFC, TNFSF3, TNLG1C, p33
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q06643Lymphotoxin-beta2441Ensembl, GeneID, HGNC

Source UniProt

Patents262

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086743 A2026-05-26163Q06643Espacenet
EP 4705273 A22026-03-11327Q06643Espacenet
JP 2026004568 A2026-01-1452052Q06643Espacenet
JP 2026004568 A2026-01-1452053Q06643Espacenet
JP 2026004568 A2026-01-1452054Q06643Espacenet
JP 2026004568 A2026-01-1452055Q06643Espacenet
JP 2026004568 A2026-01-1452056Q06643Espacenet
JP 2026004568 A2026-01-1452057Q06643Espacenet
JP 2026004568 A2026-01-1452059Q06643Espacenet
JP 2026004568 A2026-01-1452060Q06643Espacenet

1 to 10 of 262

See all 262 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
BAMINERCEPTCHEMBL1742988Heterotrimeric lymphotoxin LTa1b2 inhibitorINHIBITOR

Source ChEMBL

Trials8

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01552681BAMINERCEPTPHASE22016-03-23ClinicalTrials.gov
NCT01181089BAMINERCEPTPHASE1/PHASE2ClinicalTrials.gov
NCT01164384BAMINERCEPTPHASE1ClinicalTrials.gov
NCT00664716BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00664573BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00523328BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00458861BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00292422BAMINERCEPTPHASE2ClinicalTrials.gov

NIH grants1,907

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLTB papersNewest fiscal year
P30CA016672Cancer Center Support Grant132025
P30CA008748Cancer Center Support Grant72025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant72025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease62025
UL1TR001863Yale Clinical and Translational Science Award62025
P30CA016056Roswell Park Cancer Center Support Grant52025
P01CA155258Integrative Oncogenomics of Multiple Myeloma42025
P30CA016058Cancer Center Support Grant42025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital42025
U19AI118626Respiratory pathogen-specific T cell signatures following vaccination, natural infection, and treatment42025

1 to 10 of 1,907Source NIH's project files

See all 1,907 nih grants

Papers2,481

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Liver-eye axis in metabolic syndrome: integrated evidence from mendelian randomization, single-cell sequencing, and clinical sample validation.Front Endocrinol (Lausanne)202642780180PubTator, text miningPubMed
Youthful systemic factors restore aged liver regeneration through LTβ-driven hepatocyte reprogramming.J Hepatol202642772698PubTator, text miningPubMed
Stratifying lung adenocarcinoma: a novel prognostic model based on mitochondrial outer membrane permeabilization activity.3 Biotech202642745950PubTator, text miningPubMed
Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes.J Clin Invest202642741944PubTator, text miningPubMed
Identification of NETs and inflammation-related prognostic genes in breast cancer and PCR experimental validation.Front Genet202642695096PubTator, text miningPubMed
Single-cell transcriptomic profile unveils distinct immune ecosystems in alcohol- and nonalcohol-associated hepatocellular carcinoma.Front Immunol202642682632PubTator, text miningPubMed
Combination antagonism of TNF superfamily signaling for T cell immunosuppression.Front Immunol202642564165PubTator, text miningPubMed
Exploring LTB-mediated T cell differentiation as a prognostic marker in triple-negative breast cancer.Breast Cancer Res202642381077PubTator, text miningPubMed
Single-cell transcriptomic analysis identifies a tumor-enriched GIMAP7⁺ CD4⁺ naïve T cell population with a unique immunoregulatory state in lung adenocarcinoma.Funct Integr Genomics202642371181PubTator, text miningPubMed
Decoding isonicotinylation-associated patterns in neutrophil chronic obstructive pulmonary disease: evidence from integrative bioinformatic-driven multi-omics and in vitro validation.Front Physiol202642344274PubTator, text miningPubMed

1 to 10 of 2,481

See all 2,481 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4050

GET https://conductscience.org/api/genes/v1/4050/patents?page=2