ConductScience.org, home

Gene · 4052

LTBP1: latent transforming growth factor beta binding protein 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. LTBP1: latent transforming growth factor beta binding protein 1. Genes, record 4052. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4052

On this page

Gene

Symbol
LTBP1
HGNC
Name
latent transforming growth factor beta binding protein 1
HGNC
NCBI Gene ID
4052
NCBI Gene
HGNC ID
HGNC:6714
HGNC
Ensembl
ENSG00000049323
NCBI Gene
Aliases
ARCL2E
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14766Latent-transforming growth factor beta-binding protein 11,7211Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451166Q14766Espacenet
EP 4650780 A22025-11-1911989Q14766Espacenet
EP 4641201 A22025-10-2912858Q14766Espacenet
JP 2025147176 A2025-10-068096Q14766Espacenet
JP 2025529142 A2025-09-046940Q14766Espacenet
US 12371689 B22025-07-296940Q14766Espacenet
JP 2025517969 A2025-06-1212858Q14766Espacenet
JP 2025517970 A2025-06-1211989Q14766Espacenet
JP 2025028160 A2025-02-288096Q14766Espacenet
KR 1020250010750 A2025-01-218096Q14766Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,065

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLTBP1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant52025
P30EY010572Ophthalmology Core Facility42025
P30CA016672Cancer Center Support Grant32025
K01HL164687Novel molecular mechanisms of vascular smooth muscle cell-mediated large and small artery calcification22025
P30AR075055Core Center for Musculoskeletal Biology and Medicine22025
P30CA014051Cancer Center Support (Core) Grant22025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025
P30CA016087Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology22025

1 to 10 of 1,065Source NIH's project files

See all 1,065 nih grants

Papers1,352

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Natural Asp-tRNA synthetase fragment targets myofibroblasts to abrogate tissue fibrosis.J Biol Chem202642815638PubTator, text miningPubMed
Hippo-YAP/TAZ signaling in gastric cancer: orchestrating epithelial-stromal heterogeneity, plasticity, and therapy resistance.Cancer Heterog Plast202642770147PubTator, text miningPubMed
Composition and Function of Decellularized Human Lung Extracellular Matrix from Congenital Pulmonary Airway Malformation.J Clin Med202642739747PubTator, text miningPubMed
Immune Cell-Specific Regulatory Gene Prioritization in Low Back Pain Using Single-Cell eQTL-Informed Mendelian Randomization and Colocalization.J Pain Res202642677292PubTator, text miningPubMed
Loss of MGAT3 Amplifies TGF-β Signaling to Promote Bronchiolitis Obliterans Progression.Clin Lab202642570673PubTator, text miningPubMed
Structural basis for the contribution of latent TGFβ binding protein to TGFβ latency and activation.Nat Commun202642557249PubTator, text miningPubMed
Cross-Tissue Transcriptome-Wide Association Study Prioritizes Candidate Genes and Compound-Associated Signatures for Osteoarthritis.Curr Pharm Des202642381324PubTator, text miningPubMed
MCCC2 stabilizes LTBP1 via suppressing SMURF1-dependent ubiquitination to drive bone metastasis in prostate cancer.Oncogene202642251191PubTator, text miningPubMed
Screening and Validation of LTBP1 as a Key Target of Oxymatrine in Inhibiting Cardiac Fibroblast Differentiation Under High Glucose Conditions: In Vitro and Bioinformatic Studies.Int J Mol Sci202642074126PubTator, text miningPubMed
Cellular Senescence of Patient-derived Fibroblasts Reveals the Mid-old Stage as a Critical Window for Transcriptomic Signatures Linked to Alzheimer's Disease Biomarkers and Classification.Clin Psychopharmacol Neurosci202642036745PubTator, text miningPubMed

1 to 10 of 1,352

See all 1,352 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4052

GET https://conductscience.org/api/genes/v1/4052/patents?page=2