Gene · 4055
LTBR: lymphotoxin beta receptor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LTBR: lymphotoxin beta receptor. Genes, record 4055. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4055
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P36941 | Tumor necrosis factor receptor superfamily member 3 | 435 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents104
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4724490 A2 | 2026-04-15 | 1 | P36941 | Espacenet |
| WO 2026019692 A2 | 2026-01-22 | 29 | P36941 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 716 | P36941 | Espacenet |
| EP 4642792 A1 | 2025-11-05 | 54 | P36941 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8143 | P36941 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16767 | P36941 | Espacenet |
| JP 2025131712 A | 2025-09-09 | 5 | P36941 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2489 | P36941 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6944 | P36941 | Espacenet |
| WO 2025184170 A1 | 2025-09-04 | 38 | P36941 | Espacenet |
1 to 10 of 104
See all 104 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| HCBE-11 | CHEMBL2109509 | Tumor necrosis factor receptor superfamily member 3 agonist | AGONIST |
Source ChEMBL
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,138
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LTBR papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 16 | 2025 |
| U19AI070535 | Airway Inflammation and Airway Remodeling in Severe Asthma | 13 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| T32AI007496 | Interdisciplinary Training Program in Immunology | 7 | 2025 |
| P01CA065493 | Off-the-Shelf Immune Effector Cells for Hematological Malignancies | 5 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 5 | 2025 |
| T32CA154274 | Training Grant in Cancer Biology | 5 | 2025 |
| P30AR070253 | Joint Biology Consortium Resource-based Center | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 2,138Source NIH's project files
See all 2,138 nih grantsPapers3,299
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Tertiary lymphoid structures in urothelial carcinoma: bridging spatial architecture with therapeutic vulnerability in the post-BCG era. | Front Immunol | 2026 | 42774854 | PubTator, text mining | PubMed |
| Youthful systemic factors restore aged liver regeneration through LTβ-driven hepatocyte reprogramming. | J Hepatol | 2026 | 42772698 | PubTator, text mining | PubMed |
| Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization. | Nat Rev Immunol | 2026 | 42749753 | PubTator, text mining | PubMed |
| Daily HIV pre-exposure prophylaxis enhances monocyte activation and reprogrammes immune cell metabolism. | Front Immunol | 2026 | 42666216 | PubTator, text mining | PubMed |
| TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors. | J Physiol | 2026 | 42516061 | PubTator, text mining | PubMed |
| Radiotherapy and tertiary lymphoid structures: balancing immune activation and immune damage in cancer immunotherapy. | Mol Cancer | 2026 | 42482188 | PubTator, text mining | PubMed |
| Targeting lymphotoxin β receptor: from mechanism to precision therapy. | J Enzyme Inhib Med Chem | 2026 | 42377217 | PubTator, text mining | PubMed |
| Radiation-Induced Tumor-Intrinsic LTβR N-Glycosylation Suppresses Pyroptosis Through TRIM28-Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance. | Adv Sci (Weinh) | 2026 | 42325190 | PubTator, text mining | PubMed |
| TCF1+CD4+ T cells and microglia co-orchestrate tertiary lymphoid structures to enhance prognosis and immunotherapy in non-small cell lung cancer with brain metastases. | EBioMedicine | 2026 | 42085932 | PubTator, text mining | PubMed |
| Selective elimination of circulating effector CD8 T cells via LTβR blockade separates anti-CD137 efficacy from toxicity. | Sci Adv | 2026 | 42018612 | PubTator, text mining | PubMed |
1 to 10 of 3,299
See all 3,299 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4055
GET https://conductscience.org/api/genes/v1/4055/patents?page=2