Gene · 4065
LY75: lymphocyte antigen 75
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LY75: lymphocyte antigen 75. Genes, record 4065. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4065
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O60449 | Lymphocyte antigen 75 | 1,722 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents67
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025172069 A | 2025-11-20 | 78 | O60449 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2229 | O60449 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1805 | O60449 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 109 | O60449 | Espacenet |
| EP 4641203 A2 | 2025-10-29 | 69 | O60449 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2500 | O60449 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2500 | O60449 | Espacenet |
| JP 2025517967 A | 2025-06-12 | 69 | O60449 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1805 | O60449 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2229 | O60449 | Espacenet |
1 to 10 of 67
See all 67 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| RASDEGAFUSP ALFA | CHEMBL4297923 | Lymphocyte antigen 75 binding agent | BINDING AGENT |
Source ChEMBL
Trials5
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02661100 | RASDEGAFUSP ALFA | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT02495636 | RASDEGAFUSP ALFA | PHASE2 | ClinicalTrials.gov | |
| NCT02413827 | RASDEGAFUSP ALFA | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT02129075 | RASDEGAFUSP ALFA | PHASE2 | 2021-11-16 | ClinicalTrials.gov |
| NCT00948961 | RASDEGAFUSP ALFA | PHASE1/PHASE2 | ClinicalTrials.gov |
NIH grants1,428
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LY75 papers | Newest fiscal year |
|---|---|---|---|
| R01CA124515 | Crosstalk between butyrophilins and gamma delta T cells in human cancer | 7 | 2025 |
| P30CA034196 | Cancer Center Support (CORE) Grant | 6 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 5 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 5 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 5 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 5 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 4 | 2025 |
| P51OD011132 | Emory National Primate Research Center | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,428Source NIH's project files
See all 1,428 nih grantsPapers1,798
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Improved protocol for isolation and characterization of human thymic epithelial cells. | J Immunol Methods | 2026 | 42679888 | PubTator, text mining | PubMed |
| Risk factors of clonal hematopoiesis of indeterminate potential. | Clin Med (Lond) | 2026 | 42570703 | PubTator, text mining | PubMed |
| Why is the antigen uptake receptor DEC205 (CD205) of interest? | Expert Rev Clin Immunol | 2026 | 42305100 | PubTator, text mining | PubMed |
| Metabolic Tagging of Tumour Extracellular Vesicles for Targeted Modulation of Dendritic Cells. | J Extracell Vesicles | 2026 | 42209448 | PubTator, text mining | PubMed |
| A multimodal atlas for immunotherapeutic targeting of AML surface heterogeneity. | iScience | 2026 | 41959675 | PubTator, text mining | PubMed |
| Circular RNA as a New Vaccine Platform: Considerations, Challenges, and Perspectives. | Vaccines (Basel) | 2026 | 41893758 | PubTator, text mining | PubMed |
| Tim-3-targeted vaccines overcome tumor immunosuppression and reduce cDC1 dependence to elicit potent anti-tumor immunity. | Proc Natl Acad Sci U S A | 2026 | 41855265 | PubTator, text mining | PubMed |
| Dual-Targeting mRNA Cancer Vaccines for Simultaneous Antigen Presentation in Dendritic and Tumor Cells. | ACS Nano | 2026 | 41841891 | PubTator, text mining | PubMed |
| Rational design of next-generation vaccine adjuvants: From molecular mechanisms to hybrid delivery platforms. | Hum Vaccin Immunother | 2026 | 41837360 | PubTator, text mining | PubMed |
| CD28-deficient mice are vulnerable to mouse papillomavirus MmuPV1 infection of the skin and mucosae. | PLoS Pathog | 2026 | 41805718 | PubTator, text mining | PubMed |
1 to 10 of 1,798
See all 1,798 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4065
GET https://conductscience.org/api/genes/v1/4065/patents?page=2