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LYN: LYN proto-oncogene, Src family tyrosine kinase

1 protein, 67 patents, 9 drugs, 272 trials, 4,469 NIH grants and 6,680 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLYNHGNC
NameLYN proto-oncogene, Src family tyrosine kinaseHGNC
NCBI Gene ID4067NCBI Gene
HGNC IDHGNC:6735HGNC
EnsemblENSG00000254087NCBI Gene
AliasesJTK8, SAIDV, p53Lyn, p56LynNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P07948Tyrosine-protein kinase Lyn5126Ensembl, GeneID, HGNCUniProt

Patents 67

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469772P07948Espacenet
EP 4650780 A22025-11-1915177P07948Espacenet
EP 4641201 A22025-10-2918077P07948Espacenet
JP 2025517969 A2025-06-1218077P07948Espacenet
JP 2025517970 A2025-06-1215177P07948Espacenet
EP 4484957 A12025-01-01116P07948Espacenet
EP 4373841 A12024-05-2956P07948Espacenet
US 11884978 B22024-01-30584P07948Espacenet
WO 2023162878 A2023-08-31116P07948Espacenet
US 11685954 B22023-06-27235P07948Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BAFETINIBCHEMBL206834Tyrosine-protein kinase Lyn inhibitorINHIBITORChEMBL
BOSUTINIBCHEMBL288441Tyrosine-protein kinase Lyn inhibitorINHIBITORChEMBL
DASATINIB ANHYDROUSCHEMBL1421SRC inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885SRC inhibitorINHIBITORChEMBL
ILORASERTIBCHEMBL1980297SRC inhibitorINHIBITORChEMBL
JNJ-26483327CHEMBL3109738Tyrosine-protein kinase Lyn inhibitorINHIBITORChEMBL
TG100-801CHEMBL403989SRC inhibitorINHIBITORChEMBL
TOLIMIDONECHEMBL8030Tyrosine-protein kinase Lyn positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
XL-228CHEMBL3545085SRC inhibitorINHIBITORChEMBL

Trials 272

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06423911BOSUTINIBPHASE3ClinicalTrials.gov
NCT06390319DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06355037DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06336395DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06297161BOSUTINIBClinicalTrials.gov
NCT06124157DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06055621DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT05993949DASATINIB ANHYDROUSPHASE1ClinicalTrials.gov
NCT05751044DASATINIB ANHYDROUSPHASE1/PHASE2ClinicalTrials.gov
NCT05559008DASATINIB ANHYDROUSPHASE1/PHASE2ClinicalTrials.gov

NIH grants 4469

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant792,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant202,025NIH's project files
P30CA008748Cancer Center Support Grant192,025NIH's project files
P30CA016058Cancer Center Support Grant192,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)172,025NIH's project files
ZIAAI000898B Cell Biology142,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center102,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase92,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support82,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant82,025NIH's project files

Papers 6680

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827399PubTator, text miningPubMed
42819776PubTator, text miningPubMed
42815951PubTator, text miningPubMed
42812887PubTator, text miningPubMed
42778661PubTator, text miningPubMed
42667124PubTator, text miningPubMed
42606736PubTator, text miningPubMed
42595622PubTator, text miningPubMed
42589421PubTator, text miningPubMed
42539170PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license