ConductScience.org, home

Gene · 4070

TACSTD2: tumor associated calcium signal transducer 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. TACSTD2: tumor associated calcium signal transducer 2. Genes, record 4070. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4070

On this page

Gene

Symbol
TACSTD2
HGNC
Name
tumor associated calcium signal transducer 2
HGNC
NCBI Gene ID
4070
NCBI Gene
HGNC ID
HGNC:11530
HGNC
Ensembl
ENSG00000184292
NCBI Gene
Aliases
EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09758Tumor-associated calcium signal transducer 23237Ensembl, GeneID, HGNC

Source UniProt

Patents124

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026219249 A12026-10-2235P09758Espacenet
WO 2026219939 A12026-10-2274P09758Espacenet
US 12662549 B22026-06-2339P09758Espacenet
EP 4754143 A12026-06-1086P09758Espacenet
JP 2026516605 A2026-05-2639P09758Espacenet
JP 2026515744 A2026-05-19370P09758Espacenet
JP 2026515434 A2026-05-1873P09758Espacenet
JP 2026514790 A2026-05-1338P09758Espacenet
JP 2026513240 A2026-04-231P09758Espacenet
EP 4688866 A12026-02-1139P09758Espacenet

1 to 10 of 124

See all 124 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DATOPOTAMAB DERUXTECANCHEMBL4297939Tumor-associated calcium signal transducer 2 binding agentBINDING AGENTChEMBL
SACITUZUMAB GOVITECANCHEMBL3545262Tumor-associated calcium signal transducer 2 binding agentBINDING AGENTChEMBL

Trials156

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07582887SACITUZUMAB GOVITECANClinicalTrials.gov
NCT07582887DATOPOTAMAB DERUXTECANClinicalTrials.gov
NCT07561463SACITUZUMAB GOVITECANPHASE2ClinicalTrials.gov
NCT07535437DATOPOTAMAB DERUXTECANPHASE1/PHASE2ClinicalTrials.gov
NCT07504588SACITUZUMAB GOVITECANPHASE2ClinicalTrials.gov
NCT07492914SACITUZUMAB GOVITECANPHASE2ClinicalTrials.gov
NCT07438600SACITUZUMAB GOVITECANPHASE2ClinicalTrials.gov
NCT07393555SACITUZUMAB GOVITECANPHASE2ClinicalTrials.gov
NCT07368543SACITUZUMAB GOVITECANPHASE2ClinicalTrials.gov
NCT07367178SACITUZUMAB GOVITECANPHASE2ClinicalTrials.gov

1 to 10 of 156

See all 156 trials

NIH grants1,195

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTACSTD2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant222025
P30CA016672Cancer Center Support Grant202025
P30CA016042Cancer Center Support Grant142025
P30CA014520UW Comprehensive Cancer Center Support132025
P30CA016359Cancer Center Support Grant122025
UL1TR001863Yale Clinical and Translational Science Award122025
P50CA097186The Pacific Northwest Prostate Cancer SPORE112025
R01DK101332Induction and Evolution of Metaplasia in the Stomach82025
I01BX000930Oxyntic Atrophy and Novel Gastric Lineages.72025
T32CA009056Tumor Cell Biology Training Program72025

1 to 10 of 1,195Source NIH's project files

See all 1,195 nih grants

Papers3,230

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Sacituzumab govitecan in metastatic breast cancer: a systematic review and meta-analysis of its clinical benefit and safety.Front Med (Lausanne)202642827466PubTator, text miningPubMed
Biomarker-Driven Treatments for Ovarian Cancer: Moving Beyond HRD?Int J Womens Health202642824309PubTator, text miningPubMed
Antibody-drug conjugates in breast cancer: redefining targeted therapy.J Clin Invest202642820303PubTator, text miningPubMed
Quantitative Systems Pharmacology Model for TROP-2 Targeted Antibody-Drug Conjugate in Triple-Negative Breast Cancer.bioRxiv202642818000PubTator, text miningPubMed
Systemic and intracranial activity of antibody-drug conjugates in patients with non-small cell lung cancer and brain metastases: A systematic review and meta-analysis.Lung Cancer202642815252PubTator, text miningPubMed
Time to Rethink Pathology Reporting in Adenoid Cystic Carcinoma.Head Neck202642811719PubTator, text miningPubMed
A phase I, first-in-human dose-escalation and triple-negative breast cancer dose-expansion study of a TROP2-ADC F0024 (FDA018).Eur J Cancer202642810148PubTator, text miningPubMed
Dermatologic adverse events associated with Sacituzumab Govitecan: an international retrospective study from the EADV Task Force "Dermatology for Cancer Patients" and pharmacovigilance analysis.Breast Cancer Res Treat202642804021PubTator, text miningPubMed
TROP2-Targeting Chimeras (TRTACs) for Tumor Cell-Selective Membrane Protein Degradation and Enhanced Drug Delivery.Adv Sci (Weinh)202642801692PubTator, text miningPubMed
Antibody-Drug Conjugates in Lung Cancer: Promise, Progress, and Persistent Challenges.Curr Issues Mol Biol202642793224PubTator, text miningPubMed

1 to 10 of 3,230

See all 3,230 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4070

GET https://conductscience.org/api/genes/v1/4070/patents?page=2