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EPCAM: epithelial cell adhesion molecule

1 protein, 212 patents, 10 drugs, 26 trials, 7,788 NIH grants and 21,265 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEPCAMHGNC
Nameepithelial cell adhesion moleculeHGNC
NCBI Gene ID4072NCBI Gene
HGNC IDHGNC:11529HGNC
EnsemblENSG00000119888NCBI Gene
Aliases17-1A, 323/A3, Ber-Ep4, BerEp4, CD326, CO-17A, DIAR5, EGP-2, EGP314, EGP34, EGP40, ESA, Ep-CAM, GA733-2, HEA125, HNPCC8, KS1/4, KSA, LYNCH8, Ly74, M4S1, MH99, MIC18, MK-1, MOC-31, MOC31, TACST-1, TACSTD1, TROP1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P16422Epithelial cell adhesion molecule3142Ensembl, GeneID, HGNCUniProt

Patents 212

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026189672 A12026-09-1759P16422Espacenet
WO 2026190350 A12026-09-1759P16422Espacenet
JP 2026067851 A2026-04-21404P16422Espacenet
US 12600781 B22026-04-14469P16422Espacenet
WO 2026013158 A12026-01-15415P16422Espacenet
JP 2026004568 A2026-01-1445123P16422Espacenet
US 12522669 B22026-01-134P16422Espacenet
JP 2025538347 A2025-11-286P16422Espacenet
US 12479929 B22025-11-254P16422Espacenet
EP 4650780 A22025-11-192248P16422Espacenet

Drugs 10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADECATUMUMABCHEMBL2108018Epithelial cell adhesion molecule inhibitorINHIBITORChEMBL
CATUMAXOMABCHEMBL2108581Epithelial cell adhesion molecule cross-linking agentCROSS-LINKING AGENTChEMBL
CITATUZUMAB BOGATOXCHEMBL1743000Epithelial cell adhesion molecule binding agentBINDING AGENTChEMBL
EDRECOLOMABCHEMBL2108955Epithelial cell adhesion molecule cross-linking agentCROSS-LINKING AGENTChEMBL
IGN-101CHEMBL2109259Epithelial cell adhesion molecule binding agentBINDING AGENTChEMBL
ING-1CHEMBL2109263Epithelial cell adhesion molecule otherOTHERChEMBL
MOC31-PECHEMBL2109265Epithelial cell adhesion molecule binding agentBINDING AGENTChEMBL
OPORTUZUMAB MONATOXCHEMBL1743052Epithelial cell adhesion molecule binding agentBINDING AGENTChEMBL
SOLITOMABCHEMBL2109264Epithelial cell adhesion molecule cross-linking agentCROSS-LINKING AGENTChEMBL
TUCOTUZUMAB CELMOLEUKINCHEMBL2108660Epithelial cell adhesion molecule otherOTHERChEMBL

Trials 26

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07113522ADECATUMUMABPHASE2ClinicalTrials.gov
NCT04859751OPORTUZUMAB MONATOXPHASE3ClinicalTrials.gov
NCT04799847CATUMAXOMABPHASE1/PHASE2ClinicalTrials.gov
NCT04222114CATUMAXOMABPHASE3ClinicalTrials.gov
NCT03258593OPORTUZUMAB MONATOXPHASE12023-10-26ClinicalTrials.gov
NCT02449239OPORTUZUMAB MONATOXPHASE32023-07-24ClinicalTrials.gov
NCT01815528CATUMAXOMABPHASE2ClinicalTrials.gov
NCT01246440CATUMAXOMABPHASE2ClinicalTrials.gov
NCT01061645MOC31-PEPHASE1ClinicalTrials.gov
NCT00866944ADECATUMUMABPHASE2ClinicalTrials.gov

NIH grants 7788

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1622,025NIH's project files
P30CA016672Cancer Center Support Grant1372,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support482,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028462,025NIH's project files
P30CA016058Cancer Center Support Grant432,025NIH's project files
P30CA006973Regional Oncology Research Center422,025NIH's project files
P30CA016086Cancer Center Support Grant412,025NIH's project files
R01CA129933Modeling Metastasis and Acquired Drug Resistance Using Circulating Tumor Cells352,025NIH's project files
K12CA087723Dana Farber/Harvard Cancer Consortium Career Development Program in Clinical Oncology322,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)302,025NIH's project files

Papers 21265

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822083PubTator, text miningPubMed
42810632PubTator, text miningPubMed
42809727PubTator, text miningPubMed
42801369PubTator, text miningPubMed
42794641PubTator, text miningPubMed
42794513PubTator, text miningPubMed
42793094PubTator, text miningPubMed
42784035PubTator, text miningPubMed
42768301PubTator, text miningPubMed
42763145PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license