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Gene · 4082

MARCKS: myristoylated alanine rich protein kinase C substrate

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MARCKS: myristoylated alanine rich protein kinase C substrate. Genes, record 4082. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4082

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Gene

Symbol
MARCKS
HGNC
Name
myristoylated alanine rich protein kinase C substrate
HGNC
NCBI Gene ID
4082
NCBI Gene
HGNC ID
HGNC:6759
HGNC
Ensembl
ENSG00000277443
NCBI Gene
Aliases
80K-L, MACS, PKCSL, PRKCSL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P29966Myristoylated alanine-rich C-kinase substrate3320Ensembl, GeneID, HGNC

Source UniProt

Patents84

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1918297P29966Espacenet
EP 4628099 A22025-10-081P29966Espacenet
US 12384828 B22025-08-12216P29966Espacenet
EP 4572801 A12025-06-25401P29966Espacenet
EP 4572802 A12025-06-25401P29966Espacenet
EP 4572803 A12025-06-25401P29966Espacenet
JP 2025517970 A2025-06-1218297P29966Espacenet
EP 4547266 A22025-05-07401P29966Espacenet
JP 2025032204 A2025-03-1131219P29966Espacenet
KR 1020250005239 A2025-01-091P29966Espacenet

1 to 10 of 84

See all 84 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
BIO-11006CHEMBL4297701Myristoylated alanine-rich C-kinase substrate inhibitorINHIBITOR

Source ChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04183062BIO-11006PHASE2ClinicalTrials.gov
NCT03472053BIO-11006PHASE2ClinicalTrials.gov
NCT03202394BIO-11006PHASE2ClinicalTrials.gov
NCT00648245BIO-11006PHASE2ClinicalTrials.gov

NIH grants1,773

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMARCKS papersNewest fiscal year
ZIAES090080TTP and related proteins in the regulation of gene expression112025
P30CA016672Cancer Center Support Grant92025
P30CA008748Cancer Center Support Grant82025
P30CA016058Cancer Center Support Grant42025
P01CA108671Myeloproliferative Neoplasms-Research Consortium32025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant32025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center32025
P50CA097257Brain Tumor SPORE Grant32025
R01GM086858New Molecular Probes For Protein Kinases32025

1 to 10 of 1,773Source NIH's project files

See all 1,773 nih grants

Papers2,556

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Plasma proteomic profiling of septic shock and acute pancreatitis identifies shared signatures and disease-specific pathways.Sci Rep202642702635PubTator, text miningPubMed
Phytochemical Profiling and Proteomic Insights into the Anti-Inflammatory Effects of Jing Guan Fang in LPS-Stimulated Macrophages.Antioxidants (Basel)202642650274PubTator, text miningPubMed
Spatiotemporal orchestration of macrophage heterogeneity by cell adhesion molecules.Acta Biochim Biophys Sin (Shanghai)202642634899PubTator, text miningPubMed
Real-Time Scanning Ion Conductance Microscopy Reveals MARCKS-Driven Morphological Remodeling and Nanomechanical Softening during LPS-Induced Macrophage Polarization.Anal Chem202642610913PubTator, text miningPubMed
Differential protein abundance in colostrum-derived extracellular vesicles from bovine leukemia virus-infected cattle are implicated in immune regulation and inflammation.Front Immunol202642591436PubTator, text miningPubMed
Pathophysiological and clinical significance of hepatokine Fetuin-A and myocardial N-myristoylation in heart failure.Fukushima J Med Sci202642586752PubTator, text miningPubMed
Upregulated CD177 on neutrophils is implicated in sepsis pathogenesis and necroptosis-driven inflammation.Front Immunol202642490847PubTator, text miningPubMed
Peripheral blood CADM1 expression and multi-gene signatures in depressive disorders: a pilot case-control study from the United Arab Emirates.Front Psychiatry202642459288PubTator, text miningPubMed
MARCKS as a mediator and target for pathological tunneling nanotubes between patient-derived glioblastoma cells and astrocytes.Cell Death Dis202642443154PubTator, text miningPubMed
Engineering CAR T Cells for Hepatocellular Carcinoma Recurrence after Liver Transplantation.bioRxiv202642427600PubTator, text miningPubMed

1 to 10 of 2,556

See all 2,556 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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