Gene · 4082
MARCKS: myristoylated alanine rich protein kinase C substrate
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MARCKS: myristoylated alanine rich protein kinase C substrate. Genes, record 4082. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4082
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P29966 | Myristoylated alanine-rich C-kinase substrate | 332 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents84
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 18297 | P29966 | Espacenet |
| EP 4628099 A2 | 2025-10-08 | 1 | P29966 | Espacenet |
| US 12384828 B2 | 2025-08-12 | 216 | P29966 | Espacenet |
| EP 4572801 A1 | 2025-06-25 | 401 | P29966 | Espacenet |
| EP 4572802 A1 | 2025-06-25 | 401 | P29966 | Espacenet |
| EP 4572803 A1 | 2025-06-25 | 401 | P29966 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 18297 | P29966 | Espacenet |
| EP 4547266 A2 | 2025-05-07 | 401 | P29966 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 31219 | P29966 | Espacenet |
| KR 1020250005239 A | 2025-01-09 | 1 | P29966 | Espacenet |
1 to 10 of 84
See all 84 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| BIO-11006 | CHEMBL4297701 | Myristoylated alanine-rich C-kinase substrate inhibitor | INHIBITOR |
Source ChEMBL
Trials4
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04183062 | BIO-11006 | PHASE2 | ClinicalTrials.gov | |
| NCT03472053 | BIO-11006 | PHASE2 | ClinicalTrials.gov | |
| NCT03202394 | BIO-11006 | PHASE2 | ClinicalTrials.gov | |
| NCT00648245 | BIO-11006 | PHASE2 | ClinicalTrials.gov |
NIH grants1,773
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MARCKS papers | Newest fiscal year |
|---|---|---|---|
| ZIAES090080 | TTP and related proteins in the regulation of gene expression | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
| P01CA108671 | Myeloproliferative Neoplasms-Research Consortium | 3 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 3 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 3 | 2025 |
| P50CA097257 | Brain Tumor SPORE Grant | 3 | 2025 |
| R01GM086858 | New Molecular Probes For Protein Kinases | 3 | 2025 |
1 to 10 of 1,773Source NIH's project files
See all 1,773 nih grantsPapers2,556
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Plasma proteomic profiling of septic shock and acute pancreatitis identifies shared signatures and disease-specific pathways. | Sci Rep | 2026 | 42702635 | PubTator, text mining | PubMed |
| Phytochemical Profiling and Proteomic Insights into the Anti-Inflammatory Effects of Jing Guan Fang in LPS-Stimulated Macrophages. | Antioxidants (Basel) | 2026 | 42650274 | PubTator, text mining | PubMed |
| Spatiotemporal orchestration of macrophage heterogeneity by cell adhesion molecules. | Acta Biochim Biophys Sin (Shanghai) | 2026 | 42634899 | PubTator, text mining | PubMed |
| Real-Time Scanning Ion Conductance Microscopy Reveals MARCKS-Driven Morphological Remodeling and Nanomechanical Softening during LPS-Induced Macrophage Polarization. | Anal Chem | 2026 | 42610913 | PubTator, text mining | PubMed |
| Differential protein abundance in colostrum-derived extracellular vesicles from bovine leukemia virus-infected cattle are implicated in immune regulation and inflammation. | Front Immunol | 2026 | 42591436 | PubTator, text mining | PubMed |
| Pathophysiological and clinical significance of hepatokine Fetuin-A and myocardial N-myristoylation in heart failure. | Fukushima J Med Sci | 2026 | 42586752 | PubTator, text mining | PubMed |
| Upregulated CD177 on neutrophils is implicated in sepsis pathogenesis and necroptosis-driven inflammation. | Front Immunol | 2026 | 42490847 | PubTator, text mining | PubMed |
| Peripheral blood CADM1 expression and multi-gene signatures in depressive disorders: a pilot case-control study from the United Arab Emirates. | Front Psychiatry | 2026 | 42459288 | PubTator, text mining | PubMed |
| MARCKS as a mediator and target for pathological tunneling nanotubes between patient-derived glioblastoma cells and astrocytes. | Cell Death Dis | 2026 | 42443154 | PubTator, text mining | PubMed |
| Engineering CAR T Cells for Hepatocellular Carcinoma Recurrence after Liver Transplantation. | bioRxiv | 2026 | 42427600 | PubTator, text mining | PubMed |
1 to 10 of 2,556
See all 2,556 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4082
GET https://conductscience.org/api/genes/v1/4082/patents?page=2