Gene · 4085
MAD2L1: mitotic arrest deficient 2 like 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MAD2L1: mitotic arrest deficient 2 like 1. Genes, record 4085. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4085
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13257 | Mitotic spindle assembly checkpoint protein MAD2A | 205 | 12 | Ensembl, GeneID, HGNC |
Source UniProt
Patents54
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 52218 | Q13257 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3734 | Q13257 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3734 | Q13257 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 48042 | Q13257 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 151013 | Q13257 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 6463 | Q13257 | Espacenet |
| JP 2020062004 A | 2020-04-23 | 982 | Q13257 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 232653 | Q13257 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 232653 | Q13257 | Espacenet |
| US 9702875 B2 | 2017-07-11 | 16 | Q13257 | Espacenet |
1 to 10 of 54
See all 54 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,607
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MAD2L1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 21 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 17 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 13 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 9 | 2025 |
| R01GM074215 | Kinetochore Specification and Function | 9 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 7 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 6 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 5 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 4 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 4 | 2025 |
1 to 10 of 1,607Source NIH's project files
See all 1,607 nih grantsPapers3,516
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Reconstitution of multistep recruitment of ULK1 to membranes in autophagy. | Sci Adv | 2026 | 42696573 | PubTator, text mining | PubMed |
| MAD2B guides chromosome stability in mitosis via the MAD2B-CIP2A signaling axis. | J Mol Cell Biol | 2026 | 42667364 | PubTator, text mining | PubMed |
| Comprehensive pan-cancer analysis and experimental validation of mitotic arrest defective 2-like 1 (MAD2L1) in colorectal cancer. | Bioimpacts | 2026 | 42666726 | PubTator, text mining | PubMed |
| Multi-Omics Identification of Vasculogenic Mimicry-Associated Molecular Subtypes in Hepatocellular Carcinoma for Prognostic Stratification and Therapeutic Response Prediction. | Cancers (Basel) | 2026 | 42588699 | PubTator, text mining | PubMed |
| MAD1L1 and MAD2L1 genes variants in spontaneous miscarriage with aneuploidy. | Chromosome Res | 2026 | 42545408 | PubTator, text mining | PubMed |
| Integrative single-cell and machine learning analysis identifies a tumor doubling time-related prognostic signature and therapeutic targets in head and neck squamous cell carcinoma. | Transl Oncol | 2026 | 42492364 | PubTator, text mining | PubMed |
| BubR1 TPR domain supports the mitotic checkpoint by promoting MCC formation and MCC-APC/C interaction. | Commun Biol | 2026 | 42477419 | PubTator, text mining | PubMed |
| Network architecture determines delay robustness in the spindle assembly checkpoint. | Sci Rep | 2026 | 42449135 | PubTator, text mining | PubMed |
| ClSAMBA regulates ray floret growth and flowering time in Chrysanthemum lavandulifolium. | Plant Sci | 2026 | 42419490 | PubTator, text mining | PubMed |
| Cumulus cells enhance oocyte genomic quality control by promoting DNA damage-induced meiotic arrest. | J Cell Sci | 2026 | 42339509 | PubTator, text mining | PubMed |
1 to 10 of 3,516
See all 3,516 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4085
GET https://conductscience.org/api/genes/v1/4085/patents?page=2