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Gene · 4085

MAD2L1: mitotic arrest deficient 2 like 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAD2L1: mitotic arrest deficient 2 like 1. Genes, record 4085. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4085

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Gene

Symbol
MAD2L1
HGNC
Name
mitotic arrest deficient 2 like 1
HGNC
NCBI Gene ID
4085
NCBI Gene
HGNC ID
HGNC:6763
HGNC
Ensembl
ENSG00000164109
NCBI Gene
Aliases
HSMAD2, MAD2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13257Mitotic spindle assembly checkpoint protein MAD2A20512Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452218Q13257Espacenet
EP 4650780 A22025-11-193734Q13257Espacenet
JP 2025517970 A2025-06-123734Q13257Espacenet
US 11446398 B22022-09-2048042Q13257Espacenet
JP 2022524081 A2022-04-27151013Q13257Espacenet
US 11078247 B22021-08-036463Q13257Espacenet
JP 2020062004 A2020-04-23982Q13257Espacenet
JP 2019054813 A2019-04-11232653Q13257Espacenet
JP 2017121241 A2017-07-13232653Q13257Espacenet
US 9702875 B22017-07-1116Q13257Espacenet

1 to 10 of 54

See all 54 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,607

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAD2L1 papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase212025
P30CA008748Cancer Center Support Grant172025
P30CA016672Cancer Center Support Grant132025
P30CA021765Cancer Center Support Grant (CCSG)92025
R01GM074215Kinetochore Specification and Function92025
P30CA016086Cancer Center Support Grant72025
P30CA014051Cancer Center Support (Core) Grant62025
P40OD010440Caenorhabditis Genetics Center52025
P30CA015704Cancer Center Support Grant42025
P30ES010126UNC Center for Environmental Health and Susceptibility42025

1 to 10 of 1,607Source NIH's project files

See all 1,607 nih grants

Papers3,516

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Reconstitution of multistep recruitment of ULK1 to membranes in autophagy.Sci Adv202642696573PubTator, text miningPubMed
MAD2B guides chromosome stability in mitosis via the MAD2B-CIP2A signaling axis.J Mol Cell Biol202642667364PubTator, text miningPubMed
Comprehensive pan-cancer analysis and experimental validation of mitotic arrest defective 2-like 1 (MAD2L1) in colorectal cancer.Bioimpacts202642666726PubTator, text miningPubMed
Multi-Omics Identification of Vasculogenic Mimicry-Associated Molecular Subtypes in Hepatocellular Carcinoma for Prognostic Stratification and Therapeutic Response Prediction.Cancers (Basel)202642588699PubTator, text miningPubMed
MAD1L1 and MAD2L1 genes variants in spontaneous miscarriage with aneuploidy.Chromosome Res202642545408PubTator, text miningPubMed
Integrative single-cell and machine learning analysis identifies a tumor doubling time-related prognostic signature and therapeutic targets in head and neck squamous cell carcinoma.Transl Oncol202642492364PubTator, text miningPubMed
BubR1 TPR domain supports the mitotic checkpoint by promoting MCC formation and MCC-APC/C interaction.Commun Biol202642477419PubTator, text miningPubMed
Network architecture determines delay robustness in the spindle assembly checkpoint.Sci Rep202642449135PubTator, text miningPubMed
ClSAMBA regulates ray floret growth and flowering time in Chrysanthemum lavandulifolium.Plant Sci202642419490PubTator, text miningPubMed
Cumulus cells enhance oocyte genomic quality control by promoting DNA damage-induced meiotic arrest.J Cell Sci202642339509PubTator, text miningPubMed

1 to 10 of 3,516

See all 3,516 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4085

GET https://conductscience.org/api/genes/v1/4085/patents?page=2