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SMAD3: SMAD family member 3

1 protein, 98 patents, 0 drugs, 0 trials, 9,431 NIH grants and 22,023 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSMAD3HGNC
NameSMAD family member 3HGNC
NCBI Gene ID4088NCBI Gene
HGNC IDHGNC:6769HGNC
EnsemblENSG00000166949NCBI Gene
AliasesHSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, hMAD-3, hSMAD3, mad3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P84022SMAD family member 342512Ensembl, GeneID, HGNCUniProt

Patents 98

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195998P84022Espacenet
EP 4640849 A22025-10-29867P84022Espacenet
EP 4641201 A22025-10-295734P84022Espacenet
JP 2025147176 A2025-10-0615625P84022Espacenet
JP 2025094220 A2025-06-24146P84022Espacenet
JP 2025094220 A2025-06-24154P84022Espacenet
JP 2025519096 A2025-06-24867P84022Espacenet
JP 2025517969 A2025-06-125734P84022Espacenet
JP 2025517970 A2025-06-125998P84022Espacenet
JP 2025032204 A2025-03-1136161P84022Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 9431

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant952,025NIH's project files
P30CA008748Cancer Center Support Grant642,025NIH's project files
P30CA068485Cancer Center Support Grant282,025NIH's project files
P30CA016058Cancer Center Support Grant262,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award262,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant242,025NIH's project files
R01HL076246Chemokines in healing myocardial infarction232,025NIH's project files
R01HL085440Resolution of inflammation in healing myocardial infarcts232,025NIH's project files
R01AA023146Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell Proliferation202,025NIH's project files
P30CA043703Case Comprehensive Cancer Center Support Grant192,025NIH's project files

Papers 22023

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826913PubTator, text miningPubMed
42825098PubTator, text miningPubMed
42820896PubTator, text miningPubMed
42818285PubTator, text miningPubMed
42818167PubTator, text miningPubMed
42816692PubTator, text miningPubMed
42814656PubTator, text miningPubMed
42813086PubTator, text miningPubMed
42812821PubTator, text miningPubMed
42804341PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license