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SMAD4: SMAD family member 4

1 protein, 98 patents, 0 drugs, 0 trials, 8,274 NIH grants and 22,156 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSMAD4HGNC
NameSMAD family member 4HGNC
NCBI Gene ID4089NCBI Gene
HGNC IDHGNC:6770HGNC
EnsemblENSG00000141646NCBI Gene
AliasesDPC4, JIP, MADH4, MYHRSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13485SMAD family member 455212Ensembl, GeneID, HGNCUniProt

Patents 98

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463748Q13485Espacenet
JP 2026004568 A2026-01-1463749Q13485Espacenet
EP 4650780 A22025-11-196658Q13485Espacenet
EP 4641201 A22025-10-296412Q13485Espacenet
JP 2025147176 A2025-10-0615626Q13485Espacenet
JP 2025094220 A2025-06-24156Q13485Espacenet
JP 2025517969 A2025-06-126412Q13485Espacenet
JP 2025517970 A2025-06-126658Q13485Espacenet
JP 2025506185 A2025-03-0748Q13485Espacenet
JP 2025028160 A2025-02-2815626Q13485Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 8274

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2232,025NIH's project files
P30CA008748Cancer Center Support Grant2162,025NIH's project files
P30CA006973Regional Oncology Research Center682,025NIH's project files
P30CA068485Cancer Center Support Grant422,025NIH's project files
P30CA016058Cancer Center Support Grant352,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases352,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award312,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant302,025NIH's project files
P30CA015704Cancer Center Support Grant302,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)252,025NIH's project files

Papers 22156

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822544PubTator, text miningPubMed
42820305PubTator, text miningPubMed
42817222PubTator, text miningPubMed
42814286PubTator, text miningPubMed
42809368PubTator, text miningPubMed
42804804PubTator, text miningPubMed
42795904PubTator, text miningPubMed
42794933PubTator, text miningPubMed
42789212PubTator, text miningPubMed
42787065PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license