ConductScience.org, home

Gene · 409

ARRB2: arrestin beta 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. ARRB2: arrestin beta 2. Genes, record 409. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/409

On this page

Gene

Symbol
ARRB2
HGNC
Name
arrestin beta 2
HGNC
NCBI Gene ID
409
NCBI Gene
HGNC ID
HGNC:712
HGNC
Ensembl
ENSG00000141480
NCBI Gene
Aliases
ARB2, ARR2, BARR2, DKFZp686L0365
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P32121Beta-arrestin-24091Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437875P32121Espacenet
JP 2025154589 A2025-10-107P32121Espacenet
JP 2025154616 A2025-10-107P32121Espacenet
JP 2025062604 A2025-04-146485P32121Espacenet
US 11884978 B22024-01-30432P32121Espacenet
US 11446398 B22022-09-206485P32121Espacenet
US 11401321 B22022-08-023P32121Espacenet
JP 2022524081 A2022-04-27109456P32121Espacenet
JP 2022518549 A2022-03-151P32121Espacenet
US 10584159 B22020-03-1086P32121Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,756

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleARRB2 papersNewest fiscal year
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors612025
R01EY011500Structure-function studies of visual arrestin192025
P30CA008748Cancer Center Support Grant112025
R01HL056687Mechanisms of Maladaptation in Heart Failure112025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis92025
P30CA016672Cancer Center Support Grant62025
P50CA092629SPORE in Prostate Cancer62025
R01GM120569Molecular basis for arrestin-mediated signaling62025
R01MH054137Structure and Function of Dopamine Receptors62025
R01NS102722Endosomal Platforms for Signaling Pain62025

1 to 10 of 1,756Source NIH's project files

See all 1,756 nih grants

Papers2,219

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Interpreting Serial Aldosterone-to-Renin Ratio Measurements in the Diagnostic Work-up of Primary Aldosteronism.J Clin Endocrinol Metab202642745422PubTator, text miningPubMed
Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins.Nat Commun202642722688PubTator, text miningPubMed
Side-Chain Homologs of Δ9-THC, Δ8-THC, and HHC Reveal Pathway Bias at CB1R and CB2R Cannabinoid Receptors.Mol Neurobiol202642625116PubTator, text miningPubMed
Sodium butyrate upregulates URAT1-mediated urate reabsorption in HK2 cells by activating FFAR2/p38 MAPK/ELK1/ARRB2 axis and relieving NF-κB-HNF1β competitive binding.Biochem Pharmacol202642546882PubTator, text miningPubMed
Factors modulating the assembly of human β2-adrenergic receptor-β-arrestin complexes.Nat Struct Mol Biol202642538433PubTator, text miningPubMed
Down-regulation of GPRC5A Confers Protection Against Periodontitis.Inflammation202642277459PubTator, text miningPubMed
Archaic Introgression Shapes Genetic Variation at Loci Associated With DNA Virus Load in Modern Humans.Genome Biol Evol202642049271PubTator, text miningPubMed
Arrb2 in hepatocytes promotes M2 macrophage polarization, ameliorates hepatic ischemia-reperfusion injury through upregulating metabolite 6-ketoLCA.Hepatol Commun202642043875PubTator, text miningPubMed
N6-methyladenosine-mediated up-regulation of ARRB2 regulates intrahepatic cholangiocarcinoma malignant progression and pemigatinib resistance through MAPK and Hippo signaling pathways.Cell Death Dis202641986296PubTator, text miningPubMed
N-Benzyl-tryptamine Derivatives as Serotonin 5-HT2A Receptor (5-HT2AR) Agonists: Focus on Different In Vitro 5-HT2AR Activity Profiles.ACS Chem Neurosci202641860444PubTator, text miningPubMed

1 to 10 of 2,219

See all 2,219 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/409

GET https://conductscience.org/api/genes/v1/409/patents?page=2