Gene · 409
ARRB2: arrestin beta 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ARRB2: arrestin beta 2. Genes, record 409. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/409
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P32121 | Beta-arrestin-2 | 409 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37875 | P32121 | Espacenet |
| JP 2025154589 A | 2025-10-10 | 7 | P32121 | Espacenet |
| JP 2025154616 A | 2025-10-10 | 7 | P32121 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 6485 | P32121 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 432 | P32121 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 6485 | P32121 | Espacenet |
| US 11401321 B2 | 2022-08-02 | 3 | P32121 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 109456 | P32121 | Espacenet |
| JP 2022518549 A | 2022-03-15 | 1 | P32121 | Espacenet |
| US 10584159 B2 | 2020-03-10 | 86 | P32121 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,756
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ARRB2 papers | Newest fiscal year |
|---|---|---|---|
| R01HL016037 | Molecular Regulation of Cardiovascular 7 TM Receptors | 61 | 2025 |
| R01EY011500 | Structure-function studies of visual arrestin | 19 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| R01HL056687 | Mechanisms of Maladaptation in Heart Failure | 11 | 2025 |
| R01DA012864 | Mechanisms and Cellular Function of Opioid Receptor Endocytosis | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P50CA092629 | SPORE in Prostate Cancer | 6 | 2025 |
| R01GM120569 | Molecular basis for arrestin-mediated signaling | 6 | 2025 |
| R01MH054137 | Structure and Function of Dopamine Receptors | 6 | 2025 |
| R01NS102722 | Endosomal Platforms for Signaling Pain | 6 | 2025 |
1 to 10 of 1,756Source NIH's project files
See all 1,756 nih grantsPapers2,219
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Interpreting Serial Aldosterone-to-Renin Ratio Measurements in the Diagnostic Work-up of Primary Aldosteronism. | J Clin Endocrinol Metab | 2026 | 42745422 | PubTator, text mining | PubMed |
| Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins. | Nat Commun | 2026 | 42722688 | PubTator, text mining | PubMed |
| Side-Chain Homologs of Δ9-THC, Δ8-THC, and HHC Reveal Pathway Bias at CB1R and CB2R Cannabinoid Receptors. | Mol Neurobiol | 2026 | 42625116 | PubTator, text mining | PubMed |
| Sodium butyrate upregulates URAT1-mediated urate reabsorption in HK2 cells by activating FFAR2/p38 MAPK/ELK1/ARRB2 axis and relieving NF-κB-HNF1β competitive binding. | Biochem Pharmacol | 2026 | 42546882 | PubTator, text mining | PubMed |
| Factors modulating the assembly of human β2-adrenergic receptor-β-arrestin complexes. | Nat Struct Mol Biol | 2026 | 42538433 | PubTator, text mining | PubMed |
| Down-regulation of GPRC5A Confers Protection Against Periodontitis. | Inflammation | 2026 | 42277459 | PubTator, text mining | PubMed |
| Archaic Introgression Shapes Genetic Variation at Loci Associated With DNA Virus Load in Modern Humans. | Genome Biol Evol | 2026 | 42049271 | PubTator, text mining | PubMed |
| Arrb2 in hepatocytes promotes M2 macrophage polarization, ameliorates hepatic ischemia-reperfusion injury through upregulating metabolite 6-ketoLCA. | Hepatol Commun | 2026 | 42043875 | PubTator, text mining | PubMed |
| N6-methyladenosine-mediated up-regulation of ARRB2 regulates intrahepatic cholangiocarcinoma malignant progression and pemigatinib resistance through MAPK and Hippo signaling pathways. | Cell Death Dis | 2026 | 41986296 | PubTator, text mining | PubMed |
| N-Benzyl-tryptamine Derivatives as Serotonin 5-HT2A Receptor (5-HT2AR) Agonists: Focus on Different In Vitro 5-HT2AR Activity Profiles. | ACS Chem Neurosci | 2026 | 41860444 | PubTator, text mining | PubMed |
1 to 10 of 2,219
See all 2,219 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/409
GET https://conductscience.org/api/genes/v1/409/patents?page=2