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Gene · 4090

SMAD5: SMAD family member 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SMAD5: SMAD family member 5. Genes, record 4090. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4090

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Gene

Symbol
SMAD5
HGNC
Name
SMAD family member 5
HGNC
NCBI Gene ID
4090
NCBI Gene
HGNC ID
HGNC:6771
HGNC
Ensembl
ENSG00000113658
NCBI Gene
Aliases
DWFC, Dwfc, JV5-1, MADH5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99717SMAD family member 54652Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1914966Q99717Espacenet
JP 2025147176 A2025-10-0615627Q99717Espacenet
JP 2025094220 A2025-06-24166Q99717Espacenet
JP 2025517970 A2025-06-1214966Q99717Espacenet
JP 2025028160 A2025-02-2815627Q99717Espacenet
KR 1020250010750 A2025-01-2115627Q99717Espacenet
JP 2024109657 A2024-08-1415466Q99717Espacenet
JP 2022541510 A2022-09-26299Q99717Espacenet
US 11446398 B22022-09-2079691Q99717Espacenet
US 11446398 B22022-09-2079692Q99717Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,968

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMAD5 papersNewest fiscal year
P30CA008748Cancer Center Support Grant122025
P30CA068485Cancer Center Support Grant112025
R01HD032067Transforming growth factor β family signaling pathways in ovarian and uterine biology112025
P30CA016672Cancer Center Support Grant72025
P30CA021765Cancer Center Support Grant (CCSG)62025
P50CA116201Mayo Clinic Breast Cancer SPORE52025
R01AA023146Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell Proliferation52025
R01HL076246Chemokines in healing myocardial infarction52025
R01HL085440Resolution of inflammation in healing myocardial infarcts52025
UL1TR001863Yale Clinical and Translational Science Award52025

1 to 10 of 1,968Source NIH's project files

See all 1,968 nih grants

Papers3,438

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Statement of retraction: Circadian Period 2 (Per2) downregulate inhibitor of differentiation 3 (Id3) expression via PTEN/AKT/Smad5 axis to inhibits glioma cell proliferation.Bioengineered202642821469PubTator, text miningPubMed
Impaired BMPR2 signalling across pulmonary hypertension subgroups: a multicentre study.ERJ Open Res202642807825PubTator, text miningPubMed
SNX8 regulates BMPR2-mediated SMAD5 proteostasis to drive epithelial-mesenchymal transition in hepatocellular carcinoma.J Transl Med202642732062PubTator, text miningPubMed
pH sensing and inflammation: linking acidic microenvironments to immune reprogramming.Front Immunol202642577824PubTator, text miningPubMed
SMAD5 as a novel susceptibility gene for congenital patent ductus arteriosus.Sci Rep202642481704PubTator, text miningPubMed
ISL@mTOMV nanoparticles: a promising approach for VM-targeted therapy in breast cancer.J Nanobiotechnology202642387550PubTator, text miningPubMed
In silico analysis suggests ELL2 as a survival-associated cross-tissue biomarker in gastric cancer.Cancer Biomark202642333064PubTator, text miningPubMed
Lineage tracing of soma-to-primordial germ cell-like conversion in human tumor cell line.iScience202642291258PubTator, text miningPubMed
Effect of the BMP4-Smad pathway on corneal immune double-arm and mechanism study.Cell Signal202642276401PubTator, text miningPubMed
Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.J Biomed Mater Res B Appl Biomater202642032797PubTator, text miningPubMed

1 to 10 of 3,438

See all 3,438 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4090

GET https://conductscience.org/api/genes/v1/4090/patents?page=2