Gene · 4090
SMAD5: SMAD family member 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SMAD5: SMAD family member 5. Genes, record 4090. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4090
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99717 | SMAD family member 5 | 465 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 14966 | Q99717 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15627 | Q99717 | Espacenet |
| JP 2025094220 A | 2025-06-24 | 166 | Q99717 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 14966 | Q99717 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15627 | Q99717 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15627 | Q99717 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15466 | Q99717 | Espacenet |
| JP 2022541510 A | 2022-09-26 | 299 | Q99717 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 79691 | Q99717 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 79692 | Q99717 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,968
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SMAD5 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 11 | 2025 |
| R01HD032067 | Transforming growth factor β family signaling pathways in ovarian and uterine biology | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P50CA116201 | Mayo Clinic Breast Cancer SPORE | 5 | 2025 |
| R01AA023146 | Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell Proliferation | 5 | 2025 |
| R01HL076246 | Chemokines in healing myocardial infarction | 5 | 2025 |
| R01HL085440 | Resolution of inflammation in healing myocardial infarcts | 5 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
1 to 10 of 1,968Source NIH's project files
See all 1,968 nih grantsPapers3,438
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Statement of retraction: Circadian Period 2 (Per2) downregulate inhibitor of differentiation 3 (Id3) expression via PTEN/AKT/Smad5 axis to inhibits glioma cell proliferation. | Bioengineered | 2026 | 42821469 | PubTator, text mining | PubMed |
| Impaired BMPR2 signalling across pulmonary hypertension subgroups: a multicentre study. | ERJ Open Res | 2026 | 42807825 | PubTator, text mining | PubMed |
| SNX8 regulates BMPR2-mediated SMAD5 proteostasis to drive epithelial-mesenchymal transition in hepatocellular carcinoma. | J Transl Med | 2026 | 42732062 | PubTator, text mining | PubMed |
| pH sensing and inflammation: linking acidic microenvironments to immune reprogramming. | Front Immunol | 2026 | 42577824 | PubTator, text mining | PubMed |
| SMAD5 as a novel susceptibility gene for congenital patent ductus arteriosus. | Sci Rep | 2026 | 42481704 | PubTator, text mining | PubMed |
| ISL@mTOMV nanoparticles: a promising approach for VM-targeted therapy in breast cancer. | J Nanobiotechnology | 2026 | 42387550 | PubTator, text mining | PubMed |
| In silico analysis suggests ELL2 as a survival-associated cross-tissue biomarker in gastric cancer. | Cancer Biomark | 2026 | 42333064 | PubTator, text mining | PubMed |
| Lineage tracing of soma-to-primordial germ cell-like conversion in human tumor cell line. | iScience | 2026 | 42291258 | PubTator, text mining | PubMed |
| Effect of the BMP4-Smad pathway on corneal immune double-arm and mechanism study. | Cell Signal | 2026 | 42276401 | PubTator, text mining | PubMed |
| Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation. | J Biomed Mater Res B Appl Biomater | 2026 | 42032797 | PubTator, text mining | PubMed |
1 to 10 of 3,438
See all 3,438 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4090
GET https://conductscience.org/api/genes/v1/4090/patents?page=2