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Gene · 4091

SMAD6: SMAD family member 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SMAD6: SMAD family member 6. Genes, record 4091. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4091

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Gene

Symbol
SMAD6
HGNC
Name
SMAD family member 6
HGNC
NCBI Gene ID
4091
NCBI Gene
HGNC ID
HGNC:6772
HGNC
Ensembl
ENSG00000137834
NCBI Gene
Aliases
AOVD2, HsT17432, MADH6, MADH7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43541SMAD family member 64960Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463759O43541Espacenet
EP 4641201 A22025-10-292950O43541Espacenet
JP 2025147176 A2025-10-0615628O43541Espacenet
JP 2025094220 A2025-06-24178O43541Espacenet
JP 2025517969 A2025-06-122950O43541Espacenet
JP 2025028160 A2025-02-2815628O43541Espacenet
KR 1020250010750 A2025-01-2115628O43541Espacenet
JP 2024109657 A2024-08-1415467O43541Espacenet
JP 2022541510 A2022-09-26304O43541Espacenet
US 11446398 B22022-09-2079693O43541Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,462

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMAD6 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30CA068485Cancer Center Support Grant72025
P30CA008748Cancer Center Support Grant62025
UL1TR001863Yale Clinical and Translational Science Award62025
R01AA023146Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell Proliferation42025
R01HL076246Chemokines in healing myocardial infarction42025
R01HL085440Resolution of inflammation in healing myocardial infarcts42025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL42025
T32HL069768Pre-doctoral Training Program in Integrative Vascular Biology42025
P30CA016042Cancer Center Support Grant32025

1 to 10 of 1,462Source NIH's project files

See all 1,462 nih grants

Papers2,156

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Complementary roles of Smad6 and Smad7 in BMP-15-mediated steroidogenic regulation in granulosa cells.Biochem Biophys Res Commun202642759274PubTator, text miningPubMed
Global downstream BMP15 pathway analysis in human ovarian granulosa cells reveals novel genetic variations associated with primary ovarian insufficiency.Maturitas202642664615PubTator, text miningPubMed
Third Patient With Biallelic Variants in SMAD6 With an Overlapping Phenotype: Developmental Delays, Dysmorphic Features, and Cardiovascular Abnormalities.Am J Med Genet A202642649516PubTator, text miningPubMed
SMAD6 is required for normal foregut development in humans and frogs.Development202642598955PubTator, text miningPubMed
Association of Pulp Stones With Single Nucleotide Polymorphisms of Mineralization-Related Genes in Orthodontically Treated Patients: A Cross-Sectional Study.Int J Dent202642564842PubTator, text miningPubMed
Association between single-nucleotide polymorphisms in endochondral development-related genes and 3D phenotypic variation of the cranial base.Head Face Med202642482084PubTator, text miningPubMed
Rare variant analysis of whole genome sequenced juvenile idiopathic arthritis multiplex pedigrees identifies rare variants in NOD2 and ACVR1.G3 (Bethesda)202642466628PubTator, text miningPubMed
Germline determinants of risk and molecular subtype in young-onset lung cancer.medRxiv202642465903PubTator, text miningPubMed
Investigation of genetic polymorphisms associated with severe root resorption in orthodontic surgery patients.Braz Dent J202642385003PubTator, text miningPubMed
Atypical Biallelic Inheritance in "Dominant" Genes: Evidence From a Large-Scale Consanguineus Exome Cohort.Am J Med Genet A202642316479PubTator, text miningPubMed

1 to 10 of 2,156

See all 2,156 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4091

GET https://conductscience.org/api/genes/v1/4091/patents?page=2