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SMAD7: SMAD family member 7

1 protein, 61 patents, 1 drug, 6 trials, 3,393 NIH grants and 7,162 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSMAD7HGNC
NameSMAD family member 7HGNC
NCBI Gene ID4092NCBI Gene
HGNC IDHGNC:6773HGNC
EnsemblENSG00000101665NCBI Gene
AliasesCRCS3, MADH7, MADH8NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15105SMAD family member 74267Ensembl, GeneID, HGNCUniProt

Patents 61

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026009430 A2026-01-2040O15105Espacenet
EP 4650780 A22025-11-192023O15105Espacenet
EP 4641202 A22025-10-294534O15105Espacenet
JP 2025147176 A2025-10-0615629O15105Espacenet
JP 2025094220 A2025-06-24182O15105Espacenet
JP 2025517970 A2025-06-122023O15105Espacenet
JP 2025032204 A2025-03-1136172O15105Espacenet
JP 2025028160 A2025-02-2815629O15105Espacenet
KR 1020250017231 A2025-02-044534O15105Espacenet
KR 1020250010750 A2025-01-2115629O15105Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
MONGERSEN SODIUMCHEMBL3707383SMAD-7 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02974322MONGERSEN SODIUMPHASE3ClinicalTrials.gov
NCT02685683MONGERSEN SODIUMPHASE2ClinicalTrials.gov
NCT02641392MONGERSEN SODIUMPHASE32019-01-29ClinicalTrials.gov
NCT02601300MONGERSEN SODIUMPHASE22018-09-12ClinicalTrials.gov
NCT02596893MONGERSEN SODIUMPHASE32019-01-23ClinicalTrials.gov
NCT02367183MONGERSEN SODIUMPHASE1ClinicalTrials.gov

NIH grants 3393

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant262,025NIH's project files
P30CA068485Cancer Center Support Grant202,025NIH's project files
P30CA016672Cancer Center Support Grant192,025NIH's project files
P30CA015704Cancer Center Support Grant142,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)122,025NIH's project files
U01CA167551Colon Cancer Family Registry Cohort112,025NIH's project files
P30CA016058Cancer Center Support Grant92,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital92,025NIH's project files
P30DK034987Center for Gastrointestinal Biology and Disease82,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases72,025NIH's project files

Papers 7162

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821809PubTator, text miningPubMed
42812821PubTator, text miningPubMed
42804630PubTator, text miningPubMed
42792557PubTator, text miningPubMed
42759274PubTator, text miningPubMed
42750953PubTator, text miningPubMed
42650029PubTator, text miningPubMed
42640988PubTator, text miningPubMed
42609873PubTator, text miningPubMed
42594169PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license