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Gene · 4093

SMAD9: SMAD family member 9

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SMAD9: SMAD family member 9. Genes, record 4093. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4093

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Gene

Symbol
SMAD9
HGNC
Name
SMAD family member 9
HGNC
NCBI Gene ID
4093
NCBI Gene
HGNC ID
HGNC:6774
HGNC
Ensembl
ENSG00000120693
NCBI Gene
Aliases
MADH6, MADH9, PPH2, SMAD8, SMAD8/9, SMAD8A, SMAD8B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15198SMAD family member 94671Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026027383 A2026-02-1832O15198Espacenet
JP 2026004568 A2026-01-1463763O15198Espacenet
JP 2026004568 A2026-01-1463764O15198Espacenet
EP 4650780 A22025-11-1910223O15198Espacenet
EP 4641201 A22025-10-2910525O15198Espacenet
JP 2025147176 A2025-10-0615630O15198Espacenet
JP 2025094220 A2025-06-24172O15198Espacenet
JP 2025517969 A2025-06-1210525O15198Espacenet
JP 2025517970 A2025-06-1210223O15198Espacenet
JP 2025028160 A2025-02-2815630O15198Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,262

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMAD9 papersNewest fiscal year
P30CA008748Cancer Center Support Grant82025
P30CA068485Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant52025
P30DK058404Molecular and Cellular Basis for Digestive Diseases52025
R01AA023146Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell Proliferation52025
R01HL124021An endothelial-fibroblast axis connecting senescence to amino acid metabolism for control of vascular stiffness in PAH52025
UL1TR001863Yale Clinical and Translational Science Award52025
R01CA236591Cellular interactions between TGF-beta pathway members and epigenetic regulators in liver and gastrointestinal cancers42025
R01HD032067Transforming growth factor β family signaling pathways in ovarian and uterine biology42025
R01HL076246Chemokines in healing myocardial infarction42025

1 to 10 of 1,262Source NIH's project files

See all 1,262 nih grants

Papers2,192

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
From Germline Variants to Tumor Outcome: GWAS-Based Functional Genomics Prioritizes Colorectal Cancer Susceptibility Genes and Links SMAD9 to Prognosis.Hum Mutat202642626603PubTator, text miningPubMed
A Case of High Pressure and High Stakes: Pulmonary Arterial Hypertension Emergence in an Infant With Hereditary Hemorrhagic Telangiectasia.Pulm Circ202642516693PubTator, text miningPubMed
Molecular-Genetic Basis of Pulmonary Arterial Hypertension (PAH).Curr Issues Mol Biol202642353577PubTator, text miningPubMed
Expression pattern of SMAD8 in geese at different reproductive stages and its effect on reproductive physiology and egg production performance.J Adv Vet Anim Res202642180270PubTator, text miningPubMed
Phenotype-specific differences in bone morphogenetic protein ligand expression and intracellular signaling pathway activation in chronic rhinosinusitis.Mol Biol Rep202642018047PubTator, text miningPubMed
Future Prospects of Imatinib in Advanced Pulmonary Hypertension Management.IUBMB Life202641885124PubTator, text miningPubMed
RNA-seq at different stages of human pancreatic β cell differentiation reveals proliferation dynamics and SMAD9 in directing β cell fate.Cell Death Dis202641807373PubTator, text miningPubMed
Bone Morphogenetic Protein (BMP) 9 Outperforms BMP2 in Osteogenesis and Osseointegration: In Vitro and In Vivo.Clin Implant Dent Relat Res202641806300PubTator, text miningPubMed
Dose-optimized HILT promotes peripheral nerve repair through BMP4-Smad9-mediated inhibition of neuroinflammation and oxidative stress.APL Bioeng202641799557PubTator, text miningPubMed
Mandibular Cortical Thickness Predicts Skull BMD in Adolescents.Calcif Tissue Int202641787089PubTator, text miningPubMed

1 to 10 of 2,192

See all 2,192 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4093

GET https://conductscience.org/api/genes/v1/4093/patents?page=2