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MAPT: microtubule associated protein tau

1 protein, 94 patents, 6 drugs, 21 trials, 21,563 NIH grants and 76,619 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMAPTHGNC
Namemicrotubule associated protein tauHGNC
NCBI Gene ID4137NCBI Gene
HGNC IDHGNC:6893HGNC
EnsemblENSG00000186868NCBI Gene
AliasesDDPAC, FLJ31424, FTD1, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, Tau-PHF6, tau, tau-40NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P10636Microtubule-associated protein tau758293Ensembl, GeneID, HGNCUniProt

Patents 94

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026183240 A12026-09-031P10636Espacenet
JP 2026120788 A2026-07-22750P10636Espacenet
EP 4716542 A12026-04-0112P10636Espacenet
US 12560619 B22026-02-2478P10636Espacenet
US 12560619 B22026-02-2490P10636Espacenet
JP 2026004568 A2026-01-1453579P10636Espacenet
WO 2025260043 A12025-12-184P10636Espacenet
EP 4663754 A22025-12-1729P10636Espacenet
EP 4640849 A22025-10-29249P10636Espacenet
EP 4641201 A22025-10-291628P10636Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BEPRANEMABCHEMBL4594612Microtubule-associated protein tau inhibitorINHIBITORChEMBL
GOSURANEMABCHEMBL3990042Microtubule-associated protein tau inhibitorINHIBITORChEMBL
POSDINEMABCHEMBL4650402Microtubule-associated protein tau inhibitorINHIBITORChEMBL
SEMORINEMABCHEMBL4298093Microtubule-associated protein tau inhibitorINHIBITORChEMBL
TILAVONEMABCHEMBL4297860Microtubule-associated protein tau inhibitorINHIBITORChEMBL
ZAGOTENEMABCHEMBL4298021Microtubule-associated protein tau inhibitorINHIBITORChEMBL

Trials 21

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04867616BEPRANEMABPHASE2ClinicalTrials.gov
NCT04658199BEPRANEMABPHASE1ClinicalTrials.gov
NCT04619420POSDINEMABPHASE2ClinicalTrials.gov
NCT04185415BEPRANEMABPHASE1ClinicalTrials.gov
NCT03828747SEMORINEMABPHASE22022-10-03ClinicalTrials.gov
NCT03712787TILAVONEMABPHASE22022-09-22ClinicalTrials.gov
NCT03658135GOSURANEMABPHASE1ClinicalTrials.gov
NCT03518073ZAGOTENEMABPHASE22022-08-30ClinicalTrials.gov
NCT03413319TILAVONEMABPHASE1ClinicalTrials.gov
NCT03391765TILAVONEMABPHASE22021-02-03ClinicalTrials.gov

NIH grants 21563

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions4582,025NIH's project files
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study4552,025NIH's project files
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)3442,025NIH's project files
P30AG066444Alzheimer's Disease Research Center3042,025NIH's project files
P30AG062421Massachusetts Alzheimer's Disease Research Center (MADRC)2462,025NIH's project files
P30AG062422New Approaches to Dementia Heterogeneity2412,025NIH's project files
P30AG062715Wisconsin Alzheimer's Disease Research Center2082,025NIH's project files
U19AG024904Alzheimer's Disease Neuroimaging Initiative (ADNI4)2072,025NIH's project files
P01AG036694Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study1932,025NIH's project files
P30AG062677Mayo Alzheimer's Disease Research Center1792,025NIH's project files

Papers 76619

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826653PubTator, text miningPubMed
42826515PubTator, text miningPubMed
42825350PubTator, text miningPubMed
42825117PubTator, text miningPubMed
42824651PubTator, text miningPubMed
42824632PubTator, text miningPubMed
42821845PubTator, text miningPubMed
42819999PubTator, text miningPubMed
42819692PubTator, text miningPubMed
42819539PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license