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Gene · 4139

MARK1: microtubule affinity regulating kinase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MARK1: microtubule affinity regulating kinase 1. Genes, record 4139. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4139

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Gene

Symbol
MARK1
HGNC
Name
microtubule affinity regulating kinase 1
HGNC
NCBI Gene ID
4139
NCBI Gene
HGNC ID
HGNC:6896
HGNC
Ensembl
ENSG00000116141
NCBI Gene
Aliases
MARK, PAR-1C, Par-1c, Par1c
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9P0L2Serine/threonine-protein kinase MARK17953Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452601Q9P0L2Espacenet
EP 4641201 A22025-10-298280Q9P0L2Espacenet
JP 2025517969 A2025-06-128280Q9P0L2Espacenet
US 11446398 B22022-09-2049188Q9P0L2Espacenet
JP 2022524081 A2022-04-27152159Q9P0L2Espacenet
US 11187708 B22021-11-302Q9P0L2Espacenet
US 10436801 B22019-10-082Q9P0L2Espacenet
JP 2019054813 A2019-04-11233036Q9P0L2Espacenet
US 9962382 B22018-05-0837Q9P0L2Espacenet
JP 2017121241 A2017-07-13233036Q9P0L2Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants996

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMARK1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes52025
P30CA016672Cancer Center Support Grant52025
P30CA014195Cancer Center Support Grant (CCSG)42025
P30CA138292Winship Cancer Institute Cancer Center Support Grant42025
P30CA006973Regional Oncology Research Center32025
P30CA016087Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P50CA097186The Pacific Northwest Prostate Cancer SPORE32025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens22025

1 to 10 of 996Source NIH's project files

See all 996 nih grants

Papers1,505

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MARK1 suppresses infectious bursal disease virus replication via phosphorylating VP3.Vet Microbiol202642617217PubTator, text miningPubMed
A Phase 2 Study of the MEK1/2 Inhibitor Luvometinib in Patients with Extracranial Arteriovenous Malformations.Clin Cancer Res202642126547PubTator, text miningPubMed
Targeting of MARK2, but not other MARKs, suppresses TNBC progression by inhibition of the mutant p53-driven signaling pathway.Chin J Nat Med202642019995PubTator, text miningPubMed
Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.Eur J Med Chem202641936796PubTator, text miningPubMed
Improving isoform-level eQTL and integrative genetic analyses of breast cancer risk with long-read RNA transcript assemblies.bioRxiv202641929126PubTator, text miningPubMed
Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders.Cells202641892327PubTator, text miningPubMed
Biologically Younger Individuals, as Identified by MARK-AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age.Aging Cell202641823324PubTator, text miningPubMed
Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations.Elife202641811178PubTator, text miningPubMed
The I's have it: everything needed to practice medical librarianship starts with an I.J Med Libr Assoc202641769354PubTator, text miningPubMed
From prostate specific antigen to genomic signatures: Advances in biomarkers for prostate cancer diagnosis and prognosis.Transl Oncol202641762538PubTator, text miningPubMed

1 to 10 of 1,505

See all 1,505 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4139

GET https://conductscience.org/api/genes/v1/4139/patents?page=2