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Gene · 4143

MAT1A: methionine adenosyltransferase 1A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAT1A: methionine adenosyltransferase 1A. Genes, record 4143. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4143

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Gene

Symbol
MAT1A
HGNC
Name
methionine adenosyltransferase 1A
HGNC
NCBI Gene ID
4143
NCBI Gene
HGNC ID
HGNC:6903
HGNC
Ensembl
ENSG00000151224
NCBI Gene
Aliases
MAT, MAT-I/III, MATA1, SAMS, SAMS1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q00266S-adenosylmethionine synthase isoform type-13954Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21305Q00266Espacenet
JP 2026004568 A2026-01-1453337Q00266Espacenet
JP 2026004568 A2026-01-1453338Q00266Espacenet
EP 4650780 A22025-11-199071Q00266Espacenet
EP 4641201 A22025-10-299345Q00266Espacenet
JP 2025517969 A2025-06-129345Q00266Espacenet
JP 2025517970 A2025-06-129071Q00266Espacenet
JP 2023521663 A2023-05-25304Q00266Espacenet
US 11446398 B22022-09-2050754Q00266Espacenet
JP 2022524081 A2022-04-27153725Q00266Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,552

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAT1A papersNewest fiscal year
P50AA011999Southern California Research Center for ALPD and Cirrhosis112025
R01AI039115Impact of RNAi and unisexual reproduction on Cryptococcus evolution, drug resistance, and pathogenesis112025
P40OD010440Caenorhabditis Genetics Center102025
P30CA008748Cancer Center Support Grant92025
P30CA006927Comprehensive Cancer Center Program at Fox Chase72025
P30ES010126UNC Center for Environmental Health and Susceptibility62025
R01AG053355Role of methylation-dependent pathways in aging and stress62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA016086Cancer Center Support Grant52025
ZIAMH002922Clinical Research in the NIMH Office of the Clinical Director52025

1 to 10 of 1,552Source NIH's project files

See all 1,552 nih grants

Papers2,373

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Deciphering early molecular responses to aristolactam I associated with hepatocellular carcinoma: Computational prediction of a core gene signature and identification of transcription-translation uncoupling under acute aristolactam I exposure.
Ecotoxicol Environ Saf202642735480PubTator, text miningPubMed
Bariatric surgery resolves MASH by enhancing MAT1A-dependent one-carbon metabolism.Nat Commun202642637748PubTator, text miningPubMed
Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology (Basel)202642583078PubTator, text miningPubMed
Equine infectious anemia virus Mat protein serves as a Tat cofactor to facilitate viral transcription.J Virol202642505242PubTator, text miningPubMed
Hindi adaptation and psychometric validation of "Stages of Change Readiness and Treatment Eagerness Scale" in alcohol dependence.Indian J Psychiatry202642495040PubTator, text miningPubMed
Comprehensive analysis of the association between perfluorooctanoic acid exposure and osteosarcoma progression.Food Chem Toxicol202642462996PubTator, text miningPubMed
Do medication adherence trajectories predict clinical endpoints in a cohort with HIV and chronic comorbidities?Res Social Adm Pharm202642401510PubTator, text miningPubMed
Evidence for Cryptic Sex in Escovopsis, a Mycoparasite in the Fungus-Growing Ant Symbiosis.Genome Biol Evol202642377967PubTator, text miningPubMed
Effects of Dietary Sulphur Amino Acid Levels on Growth Performance, Meat Quality, Nutrient Digestibility, Serum Biochemistry and Feather Follicle Transcriptomics in Jiangnan White Goslings.Animals (Basel)202642353475PubTator, text miningPubMed
CryoEM structures reveal allosteric regulation of the catalytic activity of the multi-protein human MAT enzyme complexes.IUCrJ202642329745PubTator, text miningPubMed

1 to 10 of 2,373

See all 2,373 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4143

GET https://conductscience.org/api/genes/v1/4143/patents?page=2