Gene · 4143
MAT1A: methionine adenosyltransferase 1A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MAT1A: methionine adenosyltransferase 1A. Genes, record 4143. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4143
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q00266 | S-adenosylmethionine synthase isoform type-1 | 395 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 305 | Q00266 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 53337 | Q00266 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 53338 | Q00266 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9071 | Q00266 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 9345 | Q00266 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 9345 | Q00266 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9071 | Q00266 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 304 | Q00266 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 50754 | Q00266 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 153725 | Q00266 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,552
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MAT1A papers | Newest fiscal year |
|---|---|---|---|
| P50AA011999 | Southern California Research Center for ALPD and Cirrhosis | 11 | 2025 |
| R01AI039115 | Impact of RNAi and unisexual reproduction on Cryptococcus evolution, drug resistance, and pathogenesis | 11 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 7 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 6 | 2025 |
| R01AG053355 | Role of methylation-dependent pathways in aging and stress | 6 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 5 | 2025 |
| ZIAMH002922 | Clinical Research in the NIMH Office of the Clinical Director | 5 | 2025 |
1 to 10 of 1,552Source NIH's project files
See all 1,552 nih grantsPapers2,373
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Deciphering early molecular responses to aristolactam I associated with hepatocellular carcinoma: Computational prediction of a core gene signature and identification of transcription-translation uncoupling under acute aristolactam I exposure. | Ecotoxicol Environ Saf | 2026 | 42735480 | PubTator, text mining | PubMed |
| Bariatric surgery resolves MASH by enhancing MAT1A-dependent one-carbon metabolism. | Nat Commun | 2026 | 42637748 | PubTator, text mining | PubMed |
| Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes. | Diabetology (Basel) | 2026 | 42583078 | PubTator, text mining | PubMed |
| Equine infectious anemia virus Mat protein serves as a Tat cofactor to facilitate viral transcription. | J Virol | 2026 | 42505242 | PubTator, text mining | PubMed |
| Hindi adaptation and psychometric validation of "Stages of Change Readiness and Treatment Eagerness Scale" in alcohol dependence. | Indian J Psychiatry | 2026 | 42495040 | PubTator, text mining | PubMed |
| Comprehensive analysis of the association between perfluorooctanoic acid exposure and osteosarcoma progression. | Food Chem Toxicol | 2026 | 42462996 | PubTator, text mining | PubMed |
| Do medication adherence trajectories predict clinical endpoints in a cohort with HIV and chronic comorbidities? | Res Social Adm Pharm | 2026 | 42401510 | PubTator, text mining | PubMed |
| Evidence for Cryptic Sex in Escovopsis, a Mycoparasite in the Fungus-Growing Ant Symbiosis. | Genome Biol Evol | 2026 | 42377967 | PubTator, text mining | PubMed |
| Effects of Dietary Sulphur Amino Acid Levels on Growth Performance, Meat Quality, Nutrient Digestibility, Serum Biochemistry and Feather Follicle Transcriptomics in Jiangnan White Goslings. | Animals (Basel) | 2026 | 42353475 | PubTator, text mining | PubMed |
| CryoEM structures reveal allosteric regulation of the catalytic activity of the multi-protein human MAT enzyme complexes. | IUCrJ | 2026 | 42329745 | PubTator, text mining | PubMed |
1 to 10 of 2,373
See all 2,373 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4143
GET https://conductscience.org/api/genes/v1/4143/patents?page=2