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Gene · 4145

MATK: megakaryocyte-associated tyrosine kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MATK: megakaryocyte-associated tyrosine kinase. Genes, record 4145. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4145

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Gene

Symbol
MATK
HGNC
Name
megakaryocyte-associated tyrosine kinase
HGNC
NCBI Gene ID
4145
NCBI Gene
HGNC ID
HGNC:6906
HGNC
Ensembl
ENSG00000007264
NCBI Gene
Aliases
CHK, CTK, DKFZp434N1212, HHYLTK, HYL, HYLTK, Lsk, MGC1708, MGC2101
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P42679Megakaryocyte-associated tyrosine-protein kinase5073Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452981P42679Espacenet
EP 4641201 A22025-10-294134P42679Espacenet
EP 4641202 A22025-10-294839P42679Espacenet
JP 2025517969 A2025-06-124134P42679Espacenet
KR 1020250017231 A2025-02-044839P42679Espacenet
US 11446398 B22022-09-2049941P42679Espacenet
JP 2022524081 A2022-04-27152912P42679Espacenet
JP 2019054813 A2019-04-11233416P42679Espacenet
JP 2017121241 A2017-07-13233416P42679Espacenet
JP 2015516143 A2015-06-08233416P42679Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants788

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMATK papersNewest fiscal year
P30CA016672Cancer Center Support Grant142025
P30CA008748Cancer Center Support Grant32025
P30CA042014Cancer Center Support Grant32025
R35GM130389Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches32025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR22025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes22025
P20GM103430Rhode Island IDeA Network of Biomedical Research Excellence22025
P20GM103434West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)22025
P20GM121327University of Kentucky Center for Cancer Metabolism22025
P30CA006973Regional Oncology Research Center22025

1 to 10 of 788Source NIH's project files

See all 788 nih grants

Papers2,664

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
New discoveries of Lanonia (Arecaceae) from northern Vietnam and southwestern China.PhytoKeys202642798846PubTator, text miningPubMed
DNA barcoding to delineate species boundaries and assess genetic divergence in halophytes of the United Arab Emirates.J Genet Eng Biotechnol202642749397PubTator, text miningPubMed
Fatty Acid-Binding Protein 5 Potentially Regulates the Proliferation and Metastasis of Uveal Melanoma Cells Through the PI3K/AKT/mTOR Signaling Pathway.CNS Neurosci Ther202642695184PubTator, text miningPubMed
Diagnostic Value of Oxidative Stress-Related Features Mined by WGCNA and Machine Learning in Respiratory Syncytial Virus Infection.Adv Biol (Weinh)202642500833PubTator, text miningPubMed
Adenosine Pathway-Based Prognostic Signature for Predicting Clinical Outcomes and Immune Microenvironment Characteristics in Epithelial Ovarian Cancer.J Clin Pract Res202642416131PubTator, text miningPubMed
Anatomy and the chloroplast genome of Bischofia plants reveal important phylogenetic relationship and the genetic diversity in phyllanthaceae.Sci Rep202642128939PubTator, text miningPubMed
Complete Chloroplast Genomes of Ranunculus arvensis and Ranunculus laetus: Comparative Analysis and Phylogenetic Insights.Ecol Evol202642078674PubTator, text miningPubMed
Microbial Hyaluronidases: From Obscure Virulence Factors to Promising Therapeutic Targets.Biomolecules202642072637PubTator, text miningPubMed
Integration of 117 machine learning algorithms and single-cell transcriptomics identifies macrophage polarization and ER stress signatures for cancer prognosis and precision therapy.Discov Oncol202642062606PubTator, text miningPubMed
Single-cell multi-omics sequencing reveals cell-specific transcriptomic and chromatin accessibility profiles in gut microbiome metabolite butyrate-produced pain modulation.Int J Oral Sci202641997906PubTator, text miningPubMed

1 to 10 of 2,664

See all 2,664 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4145

GET https://conductscience.org/api/genes/v1/4145/patents?page=2