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Gene · 4154

MBNL1: muscleblind like splicing regulator 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MBNL1: muscleblind like splicing regulator 1. Genes, record 4154. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4154

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Gene

Symbol
MBNL1
HGNC
Name
muscleblind like splicing regulator 1
HGNC
NCBI Gene ID
4154
NCBI Gene
HGNC ID
HGNC:6923
HGNC
Ensembl
ENSG00000152601
NCBI Gene
Aliases
EXP, EXP35, EXP40, EXP42, KIAA0428, MBNL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NR56Muscleblind-like protein 13886Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454218Q9NR56Espacenet
JP 2026004568 A2026-01-1454224Q9NR56Espacenet
EP 4650780 A22025-11-193165Q9NR56Espacenet
JP 2025147176 A2025-10-068409Q9NR56Espacenet
JP 2025147176 A2025-10-068417Q9NR56Espacenet
JP 2025529142 A2025-09-046989Q9NR56Espacenet
US 12371689 B22025-07-296989Q9NR56Espacenet
JP 2025517970 A2025-06-123165Q9NR56Espacenet
JP 2025028160 A2025-02-288409Q9NR56Espacenet
JP 2025028160 A2025-02-288417Q9NR56Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,403

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMBNL1 papersNewest fiscal year
R01NS098819Molecular effects of metformin, PKR and TBI on C9orf72 ALS/FTD142025
R35NS116846Design of Precision Small Molecules Targeting RNA Repeating Transcripts to Manipulate and Study Disease Biology112025
P30CA008748Cancer Center Support Grant92025
R01GM085319Function of Sequence-specific RNA Binding Proteins92025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant72025
R35GM118103Recognition of Cellular Targets by single and double-stranded nucleic acids72025
P30CA016672Cancer Center Support Grant62025
P30CA014051Cancer Center Support (Core) Grant52025
P30CA015704Cancer Center Support Grant52025
P30EY030413Core Grant for Vision Research52025

1 to 10 of 1,403Source NIH's project files

See all 1,403 nih grants

Papers2,262

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Alternative splicing remodeling and splicing factor regulatory networks define immune-associated molecular heterogeneity in dilated cardiomyopathy.Front Bioinform202642761222PubTator, text miningPubMed
MBNL depletion drives stem cell fusion and immature myonuclear states in myotonic dystrophy type 1.Nat Commun202642693134PubTator, text miningPubMed
CRISPR/dCas9-mediated tuning of DMPK transcription reveals a quantitative relationship between toxic repeat RNA expression and MBNL1 activity in myotonic dystrophy.Hum Mol Genet202642627995PubTator, text miningPubMed
MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias.Sci Adv202642566532PubTator, text miningPubMed
HSP90 inhibition partially rescues alternative splicing dysregulation in cell models of myotonic dystrophy.J Biol Chem202642486259PubTator, text miningPubMed
MBNL1-dependent alternative splicing promotes neuronal differentiation through regulation of NUMA1 exon 16 during fibroblast-to-neuron reprogramming.Front Cell Dev Biol202642440601PubTator, text miningPubMed
Aberrant neuronal differentiation and splicing defects in Congenital Myotonic Dystrophy (DM1) iPSC models.bioRxiv202642427665PubTator, text miningPubMed
Identification and verification of immunogenic cell death-related signatures derived from bone metastasis of prostate cancer based on multi-omics and machine learning algorithms.Comput Biol Chem202642419189PubTator, text miningPubMed
MBNL1-mediated alternative splicing in cancer: underlying mechanism, isoform regulation, and translational perspectives.Front Mol Biosci202642369965PubTator, text miningPubMed
MBNL1 Promotes Intestinal Fibrosis via RAS-MAPK Pathway-Mediated Fibroblast Activation and Proliferation.Biomedicines202642351641PubTator, text miningPubMed

1 to 10 of 2,262

See all 2,262 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4154

GET https://conductscience.org/api/genes/v1/4154/patents?page=2