Gene · 4154
MBNL1: muscleblind like splicing regulator 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MBNL1: muscleblind like splicing regulator 1. Genes, record 4154. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4154
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NR56 | Muscleblind-like protein 1 | 388 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents45
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 54218 | Q9NR56 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 54224 | Q9NR56 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3165 | Q9NR56 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8409 | Q9NR56 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8417 | Q9NR56 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6989 | Q9NR56 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6989 | Q9NR56 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3165 | Q9NR56 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 8409 | Q9NR56 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 8417 | Q9NR56 | Espacenet |
1 to 10 of 45
See all 45 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,403
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MBNL1 papers | Newest fiscal year |
|---|---|---|---|
| R01NS098819 | Molecular effects of metformin, PKR and TBI on C9orf72 ALS/FTD | 14 | 2025 |
| R35NS116846 | Design of Precision Small Molecules Targeting RNA Repeating Transcripts to Manipulate and Study Disease Biology | 11 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| R01GM085319 | Function of Sequence-specific RNA Binding Proteins | 9 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 7 | 2025 |
| R35GM118103 | Recognition of Cellular Targets by single and double-stranded nucleic acids | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 5 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 5 | 2025 |
| P30EY030413 | Core Grant for Vision Research | 5 | 2025 |
1 to 10 of 1,403Source NIH's project files
See all 1,403 nih grantsPapers2,262
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Alternative splicing remodeling and splicing factor regulatory networks define immune-associated molecular heterogeneity in dilated cardiomyopathy. | Front Bioinform | 2026 | 42761222 | PubTator, text mining | PubMed |
| MBNL depletion drives stem cell fusion and immature myonuclear states in myotonic dystrophy type 1. | Nat Commun | 2026 | 42693134 | PubTator, text mining | PubMed |
| CRISPR/dCas9-mediated tuning of DMPK transcription reveals a quantitative relationship between toxic repeat RNA expression and MBNL1 activity in myotonic dystrophy. | Hum Mol Genet | 2026 | 42627995 | PubTator, text mining | PubMed |
| MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias. | Sci Adv | 2026 | 42566532 | PubTator, text mining | PubMed |
| HSP90 inhibition partially rescues alternative splicing dysregulation in cell models of myotonic dystrophy. | J Biol Chem | 2026 | 42486259 | PubTator, text mining | PubMed |
| MBNL1-dependent alternative splicing promotes neuronal differentiation through regulation of NUMA1 exon 16 during fibroblast-to-neuron reprogramming. | Front Cell Dev Biol | 2026 | 42440601 | PubTator, text mining | PubMed |
| Aberrant neuronal differentiation and splicing defects in Congenital Myotonic Dystrophy (DM1) iPSC models. | bioRxiv | 2026 | 42427665 | PubTator, text mining | PubMed |
| Identification and verification of immunogenic cell death-related signatures derived from bone metastasis of prostate cancer based on multi-omics and machine learning algorithms. | Comput Biol Chem | 2026 | 42419189 | PubTator, text mining | PubMed |
| MBNL1-mediated alternative splicing in cancer: underlying mechanism, isoform regulation, and translational perspectives. | Front Mol Biosci | 2026 | 42369965 | PubTator, text mining | PubMed |
| MBNL1 Promotes Intestinal Fibrosis via RAS-MAPK Pathway-Mediated Fibroblast Activation and Proliferation. | Biomedicines | 2026 | 42351641 | PubTator, text mining | PubMed |
1 to 10 of 2,262
See all 2,262 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4154
GET https://conductscience.org/api/genes/v1/4154/patents?page=2