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Gene · 4157

MC1R: melanocortin 1 receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MC1R: melanocortin 1 receptor. Genes, record 4157. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4157

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Gene

Symbol
MC1R
HGNC
Name
melanocortin 1 receptor
HGNC
NCBI Gene ID
4157
NCBI Gene
HGNC ID
HGNC:6929
HGNC
Ensembl
ENSG00000258839
NCBI Gene
Aliases
CMM5, MSH-R, SHEP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01726Melanocyte-stimulating hormone receptor3175Ensembl, GeneID, HGNC

Source UniProt

Patents89

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4777830 A12026-07-2211Q01726Espacenet
EP 4640849 A22025-10-293217Q01726Espacenet
EP 4641201 A22025-10-2920698Q01726Espacenet
JP 2025529142 A2025-09-042568Q01726Espacenet
US 12371689 B22025-07-292568Q01726Espacenet
JP 2025519096 A2025-06-243217Q01726Espacenet
JP 2025517969 A2025-06-1220698Q01726Espacenet
EP 4487869 A22025-01-08302Q01726Espacenet
EP 4487869 A22025-01-08303Q01726Espacenet
KR 1020240027895 A2024-03-04492Q01726Espacenet

1 to 10 of 89

See all 89 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFAMELANOTIDECHEMBL441738Melanocortin receptor 1 agonistAGONISTChEMBL
AFAMELANOTIDE ACETATECHEMBL4297213Melanocortin receptor 1 agonistAGONISTChEMBL
DERSIMELAGONCHEMBL4802160Melanocortin receptor 1 agonistAGONISTChEMBL
MODIMELANOTIDECHEMBL3545104Melanocortin receptor 1 agonistAGONISTChEMBL

Trials20

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06388642AFAMELANOTIDEPHASE1/PHASE2ClinicalTrials.gov
NCT06144840DERSIMELAGONPHASE3ClinicalTrials.gov
NCT06109649AFAMELANOTIDEPHASE3ClinicalTrials.gov
NCT05854784AFAMELANOTIDEPHASE22025-04-27ClinicalTrials.gov
NCT05370235AFAMELANOTIDEPHASE2ClinicalTrials.gov
NCT05210582AFAMELANOTIDEPHASE2ClinicalTrials.gov
NCT05159752AFAMELANOTIDEPHASE2ClinicalTrials.gov
NCT05005975DERSIMELAGONPHASE3ClinicalTrials.gov
NCT04943159AFAMELANOTIDEPHASE22021-10-26ClinicalTrials.gov
NCT04704713AFAMELANOTIDEPHASE32021-03-19ClinicalTrials.gov

1 to 10 of 20

See all 20 trials

NIH grants1,454

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMC1R papersNewest fiscal year
P30CA008748Cancer Center Support Grant392025
R01AR043369MITF from control of pigmentation to melanoma risk252025
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment202025
P30CA076292Moffitt Cancer Center Support Grant202025
P30CA016672Cancer Center Support Grant162025
P30ES010126UNC Center for Environmental Health and Susceptibility142025
P30CA118100University of New Mexico Cancer Center Support Grant132025
P30CA042014Cancer Center Support Grant122025
P50CA121974Yale SPORE in Skin Cancer122025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant112025

1 to 10 of 1,454Source NIH's project files

See all 1,454 nih grants

Papers3,724

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Short-chain fatty acids differentially regulate feed intake and hypothalamic appetite-related genes in layer-type chicks.Front Physiol202642819174PubTator, text miningPubMed
MC1R variants in four Chinese children with red hair and hypopigmentation.J Hum Genet202642816500PubTator, text miningPubMed
Unique Features of Melanoma Risk and Diagnosis in Red-Haired Populations.Int J Mol Sci202642737661PubTator, text miningPubMed
A new species of Heremites Gray, 1845 (Squamata, Scincidae) from the transboundary Hindu Kush foothills.Zookeys202642732331PubTator, text miningPubMed
Common MC1R Variants and Parkinson Disease Progression.JAMA Neurol202642709445PubTator, text miningPubMed
MC1R Variants and Parkinson Disease Progression Genetics.JAMA Neurol202642709428PubTator, text miningPubMed
Single-cell mapping of tumor-driven macrophage reprogramming via ETV4-MC1R underlies immunotherapy resistance in colorectal cancer.Int J Surg202642682293PubTator, text miningPubMed
Acute impact of afamelanotide on UVR erythemal and melanogenic responses in healthy humans in vivo: an exploratory study.Photochem Photobiol Sci202642678656PubTator, text miningPubMed
NDP-MSH rescues LPS-induced neuroinflammation, synaptic deficits, and depressive-like behaviors in mice: involvement of MC1R-cAMP/PKA signaling.Front Pharmacol202642621255PubTator, text miningPubMed
A hybrid effectiveness-implementation trial to integrate precision skin cancer risk feedback in federally qualified health centers.Contemp Clin Trials202642600921PubTator, text miningPubMed

1 to 10 of 3,724

See all 3,724 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4157

GET https://conductscience.org/api/genes/v1/4157/patents?page=2