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Gene · 4158

MC2R: melanocortin 2 receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MC2R: melanocortin 2 receptor. Genes, record 4158. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4158

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Gene

Symbol
MC2R
HGNC
Name
melanocortin 2 receptor
HGNC
NCBI Gene ID
4158
NCBI Gene
HGNC ID
HGNC:6930
HGNC
Ensembl
ENSG00000185231
NCBI Gene
Aliases
ACTHR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01718Adrenocorticotropic hormone receptor2972Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4777830 A12026-07-2212Q01718Espacenet
JP 2025529142 A2025-09-042569Q01718Espacenet
US 12371689 B22025-07-292569Q01718Espacenet
JP 2024506145 A2024-02-0996Q01718Espacenet
KR 1020230137342 A2023-10-0496Q01718Espacenet
US 11674142 B22023-06-137Q01718Espacenet
US 11446398 B22022-09-2050026Q01718Espacenet
US 11400116 B22022-08-02153Q01718Espacenet
JP 2022524081 A2022-04-27152997Q01718Espacenet
US 11078247 B22021-08-036647Q01718Espacenet

1 to 10 of 50

See all 50 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CORTICOTROPINCHEMBL1201610Melanocortin receptor 2 agonistAGONISTChEMBL
CORTICOTROPIN ZINC HYDROXIDECHEMBL1201609Melanocortin receptor 2 agonistAGONISTChEMBL
COSYNTROPINCHEMBL2103784Melanocortin receptor 2 agonistAGONISTChEMBL
SERACTIDE ACETATECHEMBL1201489Melanocortin receptor 2 agonistAGONISTChEMBL

Trials49

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06201897CORTICOTROPINPHASE2/PHASE3ClinicalTrials.gov
NCT06079788CORTICOTROPINPHASE3ClinicalTrials.gov
NCT05279118CORTICOTROPINPHASE2/PHASE3ClinicalTrials.gov
NCT04808856CORTICOTROPINClinicalTrials.gov
NCT04306653CORTICOTROPINClinicalTrials.gov
NCT03727776CORTICOTROPINEARLY_PHASE1ClinicalTrials.gov
NCT03644771CORTICOTROPINClinicalTrials.gov
NCT03511625CORTICOTROPINPHASE3ClinicalTrials.gov
NCT03473964CORTICOTROPINClinicalTrials.gov
NCT03465111CORTICOTROPINPHASE2ClinicalTrials.gov

1 to 10 of 49

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NIH grants622

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMC2R papersNewest fiscal year
R01DK062027Mechanisms of Adrenal Differentiation102025
R01DK043140Mechanisms Leading to Adrenal Zonation72025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
R01AR073004Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin52025
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer32025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202832025
P30CA076292Moffitt Cancer Center Support Grant32025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer22025
P30CA008748Cancer Center Support Grant22025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease22025

1 to 10 of 622Source NIH's project files

See all 622 nih grants

Papers1,357

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pregnancy-induced Cushing syndrome mediated by overexpressing LHCGR with bilateral micronodular adrenocortical disease.JCEM Case Rep202642656546PubTator, text miningPubMed
Clinical features of hereditary adrenocortical unresponsiveness to adrenocorticotropin (HAUA) in Japan: from a nationwide questionnaire based survey.Endocr J202642586722PubTator, text miningPubMed
The complex lipidome as a driver of tissue-specific pathology in adrenoleukodystrophy.Mol Neurodegener202642469918PubTator, text miningPubMed
Novel Mutations in the MC2R Gene in a Patient With Familial Glucocorticoid Deficiency (FGD): A Case Report and Functional Study.Mol Genet Genomic Med202642458748PubTator, text miningPubMed
Pharmacotherapeutic strategies for the management of congenital adrenal hyperplasia.Expert Opin Pharmacother202642360153PubTator, text miningPubMed
Familial glucocorticoid deficiency due to a novel TXNRD2 variant: expanding the spectrum of a rare genetic cause.Front Endocrinol (Lausanne)202642290847PubTator, text miningPubMed
Extracellular cyclophilin A promotes B-cell acute lymphoblastic leukemia progression via MC2R.EMBO Mol Med202642271089PubTator, text miningPubMed
Advances in pharmacological treatment for congenital adrenal hyperplasia.Curr Opin Pediatr202642234636PubTator, text miningPubMed
Unmasking Hormonal Mechanisms of Hypertension in Obesity.JACC Basic Transl Sci202641864192PubTator, text miningPubMed
A rare case report of familial glucocorticoid deficiency type 4 (GCCD4) with dilated cardiomyopathy: a 3-year follow-up study.Transl Pediatr202641810200PubTator, text miningPubMed

1 to 10 of 1,357

See all 1,357 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4158

GET https://conductscience.org/api/genes/v1/4158/patents?page=2