Gene · 4158
MC2R: melanocortin 2 receptor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MC2R: melanocortin 2 receptor. Genes, record 4158. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4158
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q01718 | Adrenocorticotropic hormone receptor | 297 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents50
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4777830 A1 | 2026-07-22 | 12 | Q01718 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2569 | Q01718 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2569 | Q01718 | Espacenet |
| JP 2024506145 A | 2024-02-09 | 96 | Q01718 | Espacenet |
| KR 1020230137342 A | 2023-10-04 | 96 | Q01718 | Espacenet |
| US 11674142 B2 | 2023-06-13 | 7 | Q01718 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 50026 | Q01718 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 153 | Q01718 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 152997 | Q01718 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 6647 | Q01718 | Espacenet |
1 to 10 of 50
See all 50 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| CORTICOTROPIN | CHEMBL1201610 | Melanocortin receptor 2 agonist | AGONIST | ChEMBL |
| CORTICOTROPIN ZINC HYDROXIDE | CHEMBL1201609 | Melanocortin receptor 2 agonist | AGONIST | ChEMBL |
| COSYNTROPIN | CHEMBL2103784 | Melanocortin receptor 2 agonist | AGONIST | ChEMBL |
| SERACTIDE ACETATE | CHEMBL1201489 | Melanocortin receptor 2 agonist | AGONIST | ChEMBL |
Trials49
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06201897 | CORTICOTROPIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT06079788 | CORTICOTROPIN | PHASE3 | ClinicalTrials.gov | |
| NCT05279118 | CORTICOTROPIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT04808856 | CORTICOTROPIN | ClinicalTrials.gov | ||
| NCT04306653 | CORTICOTROPIN | ClinicalTrials.gov | ||
| NCT03727776 | CORTICOTROPIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT03644771 | CORTICOTROPIN | ClinicalTrials.gov | ||
| NCT03511625 | CORTICOTROPIN | PHASE3 | ClinicalTrials.gov | |
| NCT03473964 | CORTICOTROPIN | ClinicalTrials.gov | ||
| NCT03465111 | CORTICOTROPIN | PHASE2 | ClinicalTrials.gov |
1 to 10 of 49
See all 49 trialsNIH grants622
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MC2R papers | Newest fiscal year |
|---|---|---|---|
| R01DK062027 | Mechanisms of Adrenal Differentiation | 10 | 2025 |
| R01DK043140 | Mechanisms Leading to Adrenal Zonation | 7 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 5 | 2025 |
| R01AR073004 | Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin | 5 | 2025 |
| I01BX004293 | CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer | 3 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 3 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 3 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30DK052574 | Host-environment interactions in the pathophysiology of digestive disease | 2 | 2025 |
1 to 10 of 622Source NIH's project files
See all 622 nih grantsPapers1,357
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Pregnancy-induced Cushing syndrome mediated by overexpressing LHCGR with bilateral micronodular adrenocortical disease. | JCEM Case Rep | 2026 | 42656546 | PubTator, text mining | PubMed |
| Clinical features of hereditary adrenocortical unresponsiveness to adrenocorticotropin (HAUA) in Japan: from a nationwide questionnaire based survey. | Endocr J | 2026 | 42586722 | PubTator, text mining | PubMed |
| The complex lipidome as a driver of tissue-specific pathology in adrenoleukodystrophy. | Mol Neurodegener | 2026 | 42469918 | PubTator, text mining | PubMed |
| Novel Mutations in the MC2R Gene in a Patient With Familial Glucocorticoid Deficiency (FGD): A Case Report and Functional Study. | Mol Genet Genomic Med | 2026 | 42458748 | PubTator, text mining | PubMed |
| Pharmacotherapeutic strategies for the management of congenital adrenal hyperplasia. | Expert Opin Pharmacother | 2026 | 42360153 | PubTator, text mining | PubMed |
| Familial glucocorticoid deficiency due to a novel TXNRD2 variant: expanding the spectrum of a rare genetic cause. | Front Endocrinol (Lausanne) | 2026 | 42290847 | PubTator, text mining | PubMed |
| Extracellular cyclophilin A promotes B-cell acute lymphoblastic leukemia progression via MC2R. | EMBO Mol Med | 2026 | 42271089 | PubTator, text mining | PubMed |
| Advances in pharmacological treatment for congenital adrenal hyperplasia. | Curr Opin Pediatr | 2026 | 42234636 | PubTator, text mining | PubMed |
| Unmasking Hormonal Mechanisms of Hypertension in Obesity. | JACC Basic Transl Sci | 2026 | 41864192 | PubTator, text mining | PubMed |
| A rare case report of familial glucocorticoid deficiency type 4 (GCCD4) with dilated cardiomyopathy: a 3-year follow-up study. | Transl Pediatr | 2026 | 41810200 | PubTator, text mining | PubMed |
1 to 10 of 1,357
See all 1,357 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4158
GET https://conductscience.org/api/genes/v1/4158/patents?page=2